The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other
types of human cancer.
It thus seems possible that genetic fingerprints of infection may soon be able to provide more direct indications for the predicted role of certain bacterial pathogens in the
cause of human cancers.
The group defined a new role for two proteins implicated in the
majority of human cancers by showing they interact directly with the DNA replication machinery.
The process of integrating naturally occurring cancers in dogs into the general
studies of human cancer biology and therapy is known as comparative oncology.
Understanding these mechanisms could provide new therapeutic targets and novel approaches for virtually every
type of human cancer.
But while most PDX mice are used as general models
of human cancer in the laboratory, others seek to use them as Fiebig originally hoped — as avatars to guide customized patient care.
In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse
models of human cancers.
A family of economical silver - based complexes show very promising results against a
number of human cancers in laboratory tests, with very low toxicity in rat studies and minimal effects on healthy cells.
According to the National Cancer Institute, more than a
third of all human cancers, including a high percentage of pancreas, lung and colon cancers are driven by mutations in a family of genes known as Ras.
In the August 10 issue of Cancer Cell, American researchers show that the drug candidate inhibits tumor growth in a mouse model of breast cancer and efficiently kills a broad
range of human cancer cells.
And we can also use what we know about the
genetics of the human cancer to make mutations in normal cells, and see how different mutations drive invasion.»
The Cancer Genome Project uses human genome sequence and mutation detection techniques to find changes in DNA involved in the
development of human cancers.
However, in larger scale studies on humans and
risk of human cancers, greater intake of flavonoids has not been consistently associated with decreased risk of cancer.
The DNA of BKV has been discovered in several types
of human cancers including prostate tumours, and mouse studies suggest the virus can trigger cancer.
«Given that approximately 12 percent
of human cancers worldwide may be attributed to viruses, and there are no vaccines currently available for these five viruses, prevention strategies to reduce the infections that can lead to cancer are even more critical,» said Linda Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP).
The chemical turned up in a massive screening programme funded by the US National Cancer Institute, which tested 2500 plant extracts for toxicity to laboratory
cultures of human cancer cells.
Studying heparanase — a key enzyme in the development and
metastasis of human cancers — scientists unveiled new fluorescent imaging agents that detect enzyme activity in healthy and diseased tissues.
Liu's scientific research focuses on the functional
genomics of human cancers, particularly breast cancer, uncovering new oncogenes, and deciphering on a genomic scale the dynamics of gene regulation that modulate cancer biology.
The Nobel Prize laureate Otto Warburg who pioneered modern cancer metabolism research once said that «The
cure of human cancer will be the resultant of biochemistry of cancer and of biochemistry of man ``.
An internationally recognized authority on the genetic
basis of human cancer, Dr. Robert A. Weinberg is a founding member of the Whitehead Institute for Biomedical Research and the Daniel K. Ludwig Professor for Cancer Research at the Massachusetts Institute of Technology (MIT).
Studies have shown that more than 50 %
of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.
But she notes that even if the rodent finding is mirrored in people, only a
subset of human cancers would be influenced by the drugs — those not already abundant in NRF2.
Researchers have decoded the chemistry of the first of a wealth of unique compounds produced by a new genus of bacteria that dwells in deep - ocean sediments, and they have found it to be a potent
inhibitor of human cancers in lab experiments.
Population screening with radiographic imaging or endoscopic procedures makes no clinical or economic sense for a cancer that represent only 3 percent of estimated new cancers each year; however, with an aging population, this most
formidable of human cancers will only increase in incidence and frequency.
Using a
combination of human cancer cells and mouse models of disease, the authors examined the pathway by which squalene epoxidase promotes the development of hepatocellular carcinoma and identified terbinafine, a clinically approved antifungal drug, as a potential intervention.
But scientists have now found the oldest
example of human cancer in a 1.7 - million - year - old bone, National Geographic reports.
The use of bone marrow - derived stem cells is well established in the treatment
of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.
He will soon join the faculty at the Hillman Cancer Center at the University of Pittsburgh, satisfied knowing that he showed that aberrant chromosomal structure underlies growth of a significant
proportion of human cancers.
Up to 70 per
cent of human cancers, including many leukemias and lymphomas, have unusually high levels of MYC, which causes cancerous changes in cells by forcing them into abnormally rapid growth.
In addition, the researchers examined neuroligin - 3 data from The Cancer Genome Atlas, a large public
database of human cancer genetics.
A year later, Carlo Croce, now
director of the Human Cancer Genetics Program at Ohio State University, reported that chronic lymphocytic leukemia (CLL), the most common form of the disease, was caused by deletion of two microRNA genes.
Those microRNA molecules have been linked to heart disease and diabetes; to Alzheimer's, Parkinson's, and other neurodegenerative diseases; to longevity (at least in worms); and to the entire
spectrum of human cancers, including lung, breast, stomach, prostate, colon, pancreatic, and brain.
In the current paper, the authors adapt Poly - G repeat analysis — initially developed to study lineage relationships between single cells in mice — to the study
of human cancer for the first time.
«Given that the majority
of human cancers express Sox9, it is likely that the results of this study will be relevant for other cancers in humans and will help to define new strategies to prevent cancer formation and block tumor invasion» comments Cédric Blanpain, the last and corresponding author of this study.
Willert Home Products, a leading manufacturer of home air freshener and closet products, said during California's rulemaking that the levels people were exposed to were too low to cause harm, and that there was no
evidence of human cancer.