Statins are HMGR inhibitors with inhibition constant values in the nanomolar range that effectively lower serum cholesterol levels and are widely prescribed in the
treatment of hypercholesterolemia.
The approach described by the Nantes team thus generates clinically relevant
models of hypercholesterolemia that can be used to predict pharmacological responses, paving the way to personalize the treatment of high - risk patients.
Inspired by a little known treatment used in
cases of hypercholesterolemia, Dr. Vinh successfully developed a molecule that exclusively blocks the mutation while allowing the protein to be synthesized.
Other factors, including the addition of cholesterol (0.25 %) may also allow the researcher to induce a
combination of hypercholesterolemia, greater IR, and hyper - TG in this model compared to fructose alone (2) further improving the fructose - fed hamster's use as a model of dyslipidemia.
Model adjusted for age, race, baseline BMI, randomized treatment, nonalcohol energy intake, physical activity level, smoking status, postmenopausal status, postmenopausal hormone use, multivitamin use,
history of hypercholesterolemia and hypertension, and intake of fruit and vegetables, whole grains, refined grains, red meats and poultry, low - fat dairy products, high - fat dairy products, energy - adjusted total fat, carbohydrates, and fiber.
, Long - term cholesterol - lowering effects of psyllium as an adjunct to diet therapy in the treatment
of hypercholesterolemia, 2000