Sentences with phrase «of hypoxia»

Little is known about the molecular effects of hypoxia on the retina and the underlying relationship between hypoxia and the pathogenesis of retinal diseases.

«We observed a detrimental effect of hypoxia in animals reared under low oxygen, not apparent from observations in short term studies in adults.

Kaur et al. [68] found a maximal elevation of about twofold in the NR1 subunit of the NMDAR complex after 24 h of hypoxia using qRT — PCR.

Also, it will be of great interest to investigate the possibility that repetitive cycles of hypoxia / reoxygenation lead to the selective expansion of a pre-existing metastatic CSC subpopulation.

Schneider's searches on Google Scholar reveal that the name of Sergio Leone's film, or variations thereof, occurs in the titles of no less than 2710 papers, an example being «The Good, the Bad, and the Cell Type - Specific Roles of Hypoxia Inducible Factor - 1 in Neurons and Astrocytes» -LRB-...

Results of the study showed that increased lactate production was found by hyperpolarized MRI in areas of hypoxia, or low - oxygenation, and higher levels of FDG binding represented areas of hypermetabolic activity surrounding the hypoxic areas.

The irregular vasculature of solid tumors creates hypoxic regions, which are characterized by cyclic periods of hypoxia and reoxygenation.

Jones NM, Lee EM, Brown TG, Jarrott B, Beart PM (2006) Hypoxic preconditioning produces differential expression of hypoxia - inducible factor - 1alpha (HIF - 1alpha) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain.

Variations include The Good, the Bad and the Whole Grain (Asia Pac J Clin Nutr, 17: 16 - 19) and The Good, the Bad, and the Cell Type - Specific Roles of Hypoxia Inducible Factor - 1 in Neurons and Astrocytes (The Journal of Neuroscience, 28:1988 - 1993).

Symptoms of hypoxia include «nausea, apprehension, tunnel vision, headaches, fatigue, dizziness, blurred vision, tingling sensations, numbness, and mental confusion,» according to the Aircraft Owners and Pilots Association.

«We find that climate change will move the onset of hypoxia ~ 7 days earlier, while also decreasing oxygen in the bay primarily due to increased temperature.

Although the development of hypoxia tolerance in tumors predicts poor prognosis, mechanisms contributing to hypoxia tolerance remain to be elucidated.

The researchers had found that genes that regulate DNA repair, the cell cycle and programmed cell death are differentially regulated in Spalax when exposed to normal, above - ground oxygen levels (21 percent oxygen) and conditions of hypoxia (3, 6 and 10 percent oxygen).

Additionally, there are numerous annual areas of the Gulf where large scale fish kills occur as a result of hypoxia.

A device developed to monitor US military pilots looks at biomarkers in breath to spot the first signs of hypoxia, allowing action to be taken earlier

A statistically significant increase was observed relative to control at all hypoxic time points up to the 6 h duration of hypoxia.

EL helped to carry out the optimization of hypoxia / reoxygenation protocol, carried out the flow cytometry experiments and animal experiments, and prepared the manuscript.

A recent theme of his research is on the consequences of hypoxia - ischemia and inflammation.

Max Gassmann, DVM University of Zurich Zurich, Switzerland Effects of Hypoxia, Altitude and Smoking on Hemoglobin Concentrations

Or maybe a c - section and a dead baby when the transfer and failure to progress happened after the baby died of hypoxia in utero.

Hence the need to listen before a contraction (to get the baseline) and as the contraction is finishing for 60 seconds to detect the subtle «late deceleration» which is the hallmark of hypoxia.

They claim a low rate of low apgars, implying that their rate of hypoxia is low, but given the poor ability of non-CNM midwives to assess apgars, I don't think the claim is meaningful.

The potential benefits of hypoxia need to be carefully considered alongside potential harms, notes Stephen Archer, a cardiologist at Queen's University in Kingston, Canada.

If confirmed, this finding would have obvious relevant consequences on therapeutic and rehabilitative interventions: correction of hypoxia could be less critical than correction of inactivity.

For example, using new technologies to identify more reliable fetal biomarkers of hypoxia.

He argues that «most of the fetuses identified as being at risk of hypoxia are not» and highlights a review of trial data for nearly 37,000 women that found no difference in perinatal mortality between labours with electronic fetal monitoring versus intermittent auscultation.

The result was a relative state of hypoxia or inadequate oxygen supply, one that subsequently induced production of a protective transcription factor in fat cells called HIF - 1alpha.

Higher levels of hypoxia in a tumour are strongly linked to poor survival rates in cancer patients, he said, and hypoxic tumours are often resistant to treatment.

A combination of hypoxia and messages from the tumor cells initiates a process whereby the newly arrived macrophages assume their bad - boy identity as tumor promoters.

«NOAA's investment in the Gulf of Mexico continues to yield results that confirm the complex dynamics of hypoxia and provide managers and the public with accurate scientific information for managing and restoring the nation's valuable coastal resources,» said Robert Magnien, Ph.D., director of NOAA's Center for Sponsored Coastal Ocean Research.

NOAA's National Marine Fisheries Service, in conducting its Southeast Monitoring and Assessment Program groundfish surveys, also found large expanses of hypoxia in June - early July.

As a first step toward finding out, he subjected sleeping rats to bouts of hypoxia, or partial oxygen deprivation, that mimicked apnea episodes.

In the model, the severity of hypoxia is driven by a combination of physical factors such as the thickness of the dense, bottom layer of water during stratification, the degree of wind - driven vertical mixing, and the growth of phytoplankton induced by phosphorus loading.

Identification of these genes provides support for previously hypothesized mechanisms of high - altitude adaptation and illuminates the complexity of hypoxia - response pathways in humans.

«Understanding the sources and transport of nutrients is key to developing effective nutrient management strategies needed to reduce the size of hypoxia zones in the Gulf, Bay and other U.S. waters where hypoxia is an on - going problem.»

The history of hypoxia in the Chesapeake Bay since 1985 can be found at the EcoCheck website.

Mitochondria, known as the «powerhouse» of cells because of their role in energy production, are the main source of hypoxia - induced reprogramming in tumors.

Now a team from Wright - Patterson Air Force Base in Dayton, Ohio, has developed a real - time sensor to warn pilots of hypoxia.

A focused oligonucleotide microarray of 1,178 genes, qRT — PCR of selected transcripts, and western analysis of hypoxia inducible factor - 1α (HIF - 1α) were used to compare retinas from the hypoxic and recovery groups to control animals that were not made hypoxic.

Further evidence of hypoxia is suggested by the increases in vascular endothelial growth factor (VEGF) expression in patients with diabetic retinopathy [3 — 5] and retinopathy of prematurity (ROP)[6], because VEGF is known to be a hypoxia - inducible gene [7,8].

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

However, many genes and pathways not yet described in the context of hypoxia were also identified.

Publication: A novel injectable BRET - based in vivo imaging probe for detecting the activity of hypoxia - inducible factor regulated by the ubiquitin - proteasome system.

Overexpression of hypoxia - inducible factor 1 in common human cancers and their metastases.

An illustration of the hypoxia and reoxygenation regimen.

«At a high level, this is exploring the remarkable potential and also the limitations of hypoxia,» Mootha says.