Sentences with phrase «of ion channels»

He further researched the pathophysiological functions of ion channels in neurons as a post-doctoral fellow at Seoul National University from 2012 to 2014.

Neurotoxins from cone snails and spiders are helping neurobiologists to investigate the function of ion channels in neurons.

The OHSU scientists are interested in exploring another area of research focused on a type of ion channel in the membrane of neurons that is activated by serotonin.

Researchers who need transgenic mice from overseas have put their plans on hold, says Teresa Giraldez, who studies the role of ion channels in neurological diseases at the University of La Laguna on Tenerife.

Scientists at the USC Dornsife College of Letters, Arts and Sciences have discovered an entirely new class of ion channels.

Moreover, it opens the way to study the structure and dynamics of ion channels on their biologically relevant timescales by extending it to two - dimensional infrared spectroscopy,» says Christoph Götz, PhD student in the Vaziri lab and co-author of the paper.

Hill adds, «For the first time, we show that the complex behavior of ion channels on the branches of the neurons contributes to the shape of brain waves.»

During his postdoc, Dr. Taraska developed and used novel fluorescence methods to study the structure of ion channels in biological membranes.

«We demonstrated some time ago that a molecule called AAQ is capable of causing nerve cells to become light - sensitive, because it modifies the behavior of ion channels in their surface membranes,» Trauner says.

Blood flow or cell swelling will change it over tens of seconds, and the opening of ion channels when a neuron fires will cause changes over mere milliseconds.

The UAB group also found that a specific molecular target, the SK family of ion channels, was involved in the enhanced excitability.

Vascular smooth muscle cells isolated from ERβ - deficient mice show multiple abnormalities of ion channel function.

«Fastest measurements ever made of ion channel proteins.»

In Desmodus, neurons in the nerve connected to the small heat - sensing pits near the bat's nose splice together different parts of the Trpv1 gene to produce a version of the ion channel that's shorter at one end than the version made by other animals, including bats that feed on fruit, nectar, or insects, the team reports in tomorrow's Nature.

However, according to Norman Stockbridge, MD, PhD, US Food and Drug Administration (US FDA) Division of Cardiovascular and Renal Products, these cardiomyocytes don't exactly mirror the density and proportions of ion channels found in normal human adult cardiomyocytes.

The group of genes of the ion channels correlated strongly with the activity of two brain regions in the cerebrum and the cerebellum.

Some of them influence the voltage dependence of the ion channel, and we believe that it will be possible to exploit this mechanism in future drugs,» says Nina Ottosson, principal research engineer in the Department of Clinical and Experimental Medicine, and leading author of the article.

The pore of the ion channel is opened by removing the amino acid E90.

Ten years ago, convinced that bioelectricity plays an important role in development, Levin and his colleagues systematically altered the number of ion channels in cells in different parts of a frog embryo.

The gene encodes part of an ion channel in the membrane of the retina's cone cells, which detect color.

In principle, every neuron is unique in its behavior, owing to the unique configuration of its ion channels.

Each neuron type is modeled as hundreds of interacting electrical «compartments;» which is an approximation to simulating the millions of ion channels in a neuron.

Importantly, they observed a significant disruption of the assembly of the axon initial segment (AIS), a subcellular structure in the proximal part of the axon important for clustering of ion channels, and thus, for neurons to fire action potentials.

Pralle explains that remote control of ion channels could eventually lead to unprecedented precision in manipulating biological processes — with significant clinical and therapeutic potential.

In order to determine how complex electrical phenotype is achieved, we then investigated the networks of co-regulation of ion channels at the genetic and at the protein levels.

Dysfunction of ion channels is the cause of several diseases and can lead to cystic fibrosis or improper functioning of the nervous system, to name just a few.

I am fascinated by the function, regulation, and evolution of ion channels that underlie adaptive behaviors in a variety of animals.

Evans J. G., et al. «Redox and trace metal regulation of ion channels in the pain pathway.»

DHA is active in the membrane of ion channels in the brain, making it easier for them to change shape and transmit electrical signals, and is involved in serotonin metabolism (reduced serotonin production and / or activity is a key factor in depression).

The American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals (2013) states that «carbon dioxide has the potential to cause distress in animals via three different mechanisms: (1) pain due to formation of carbonic acid on respiratory and ocular membranes, (2) production of so - called air hunger and a feeling of breathlessness, and (3) direct stimulation of ion channels within the amygdala associated with the fear response».

The anti-epileptic medication currently in use, and the animal toxins mentioned above, reduce electrical excitability by closing a certain type of ion channel.

We study fundamental principles and mechanisms of neuronal signalling in the mammalian brain, and the roles of ion channels in behaviour, brain function, and disease.

The main function of ion channels is the maintenance of ion gradients across the cell membrane, shaping action potentials and other electrical signals, controlling the ion flow across secretary and epithelial cells, and regulating the cell volume.

The researchers discovered that two members of a class of ion channels that can sense a change in temperature were present in neural crest cells from chickens and mice.

«Studying dynamics of ion channels.»

Scientists at the University of California at Berkeley designed a system based on the structure of ion channels in neurons, which allow a single ion to pass at a time.

The dynamic interplay of calcium - free calmodulin (white yang domain) and calcium - bound calmodulin (dark yin domain) controls the opening of ion channels, shown in the background.

The diversity in the vanilloid (TRPV) receptor family of ion channels.

Local anesthetics, such as Novocain, block nerve transmission to pain centers in the central nervous system by binding to and inhibiting the function of an ion channel in the cell membrane of nerve cells known as the sodium channel.

He and his group investigate the functional roles of ion channels and neurotransmitter receptors in neurons and glia using morphological, electrophysiological and molecular biological techniques.

The cell's most ubiquitous gateways are potassium ion channels — the importance of this type of ion channels was underpinned in 2003 when Roderick MacKinnon received the Nobel Prize in Chemistry for resolving the first atomic structure of the bacterial KcsA potassium channel.

It is clear, however, that volatile anesthetics, which are more soluble in lipids than in water, primarily affect the function of ion channel and neurotransmitter receptor proteins in the membranes of nerve cells, which are lipid environments.

Axons, dendrites, and synapses contain different types of ion channels, or at least have them in differing numbers, which is why these parts of neurons have distinct electrical properties.

«From the clinical point of view, DENAQ is a great advance on AAQ, because it acts specifically on a particular type of ion channel that is essential for the transmission of signals received from the rods and cones,» says Trauner.

His doctoral research focused on the structure and function of ion channels, the proteins that mediate cellular electrical properties.