Sentences with phrase «of macrophages»

Researchers from Penn State College of Medicine, in collaboration with other scientists, have reported the role of macrophages in regulating the contractions of the colon to push digested material through the digestive tract.

What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the activation of macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.

Moreover, the idea that the brain was isolated from immune reactions was challenged long ago by insights about microglia cells, a type of macrophage which resides in the brain, engulfs antigens, and produces pro-inflammatory signaling molecules called cytokines.

These images show a reduction in the number of macrophages infiltrating atherosclerotic plaques (in green) in animals treated with the IRE1 inhibitor.

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

The researchers carried out tests that showed quebecol curbs the inflammatory response of macrophages, and some derivatives are even more effective than the original molecule.

The next step is to study the function of macrophages in salamanders and compare them with their human and mouse counterparts.

The Discher Lab has since shown that a protein on human cells called CD47 functions as a «marker of self» by interacting with a protein on the surface of macrophages called SIRPA.

Her research may lead to improved diagnostic tools and also facilitate the development of novel cancer therapies that prevent tumor recruitment of macrophages and, as a result, impair a cancer's ability to metastasize.

As it happens, Breast Milk is actually chock full of macrophages which are cells that eat bacteria, GREAT things.

In experiments with a mouse model of type 2 diabetes, however, the Joslin investigators showed that one form of the PKC molecule called PKC - delta actually defends against this inflammation process, by suppressing the population of macrophages gone wrong.

«Though it turns out that several different cells pick up the slack in the absence of macrophages, it was the neutrophil that emerged as a major contributor to debris removal.

Onion A increases anti-tumor immune response by inhibiting the immune suppression actions of macrophage and myeloid derived suppressor cells (MDSC).

«Results also identified mechanisms regulating the numbers and phenotype of macrophages in the tiny air sacs of the lungs (called alveoli) in health and disease,» said Takuji Suzuki, MD, PhD, the study's first author and a scientist in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's.

A team led by professor Massimiliano Mazzone has demonstrated that the metabolism of macrophages, a particular type of white blood cell, can be attuned to prevent the spread of cancer.

Without the involvement of macrophages and other innate cells, the premalignant tissue would remain in check.

This relies on the ability of macrophages, types of white blood cell, to produce nitric oxide when they are exposed to cytokines.

The team found that inflammatory damage in the heart can not occur without the help of macrophages and dendritic cells made by the spleen, and that heart failure is to some degree an autoimmune disease.

The next question, says Noble, is why not all smokers have emphysema, even though all of them have lungs full of macrophages.

The resulting fragments attract several types of immune cells, which led pulmonologist Steven Shapiro of Washington University in St. Louis to suspect that the fragments might also attract more of the same kind of macrophages that started destroying elastin in the first place.

Many leukemias exhibit mixed - lineage patterns of gene expression, for example of both macrophage and lymphocyte genes.

Jimenez - Garcia L, Herranz S, Higueras MA, Luque A, Hortelano S. Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization.

... After treatment of macrophages with curcuminoids, Aβ uptake by macrophages of three of the six AD patients was significantly (P < 0.001 to 0.081) increased.

Next steps: Future studies will focus on investigation of 1) the biological functions of newly identified STM protein that is required for colonization of macrophages and 2) Nramp1 - affected pathways in STM cells.

What Dr. Godwin eventually hopes to do is develop drugs derived from macrophages that will give humans the ability to heal without scarring — either directly or by triggering genes that control the formation of macrophages.

Wild - type mouse microglia respond in a dose - dependent fashion to HS - oligosaccharides isolated from MPS IIIB patients with overexpression of macrophage inflammatory protein 1α (Mip1a or Ccl3) and interleukin 1β mRNAs.

Falkenham's cream works by inciting another round of macrophages to consume the colored ones and carry them, along with the ink, into the body's lymph nodes and away from the visible surface of the skin.

His research background is in mucosal immunology and his early work was based on the role of macrophage cytokines in intestinal and lung inflammation.

While properties of macrophages have already been studied extensively, it remained unknown whether changing their metabolism would impact their functions.

«Tattoo removal can be likely improved by combining laser surgery with the transient ablation of the macrophages present in the tattoo area,» says Malissen.

«Even short - term exposure of macrophages to alcohol reduces their ability to migrate to a site of infection as well as their ability to destroy the pathogen.»

It was known that a precursor of macrophages — roving cells deployed by the immune system to consume bacteria and dead cells — speeds up fat deposition in scarred arteries.

In 2001 Jeffrey W. Pollard and his co-workers at the Albert Einstein College of Medicine described mice that were genetically engineered to be susceptible to breast cancer tumors but that produced precancerous tissue that did not turn fully malignant unless it enlisted the assistance of macrophages.

Claire E. Lewis and Munitta Muthana of the University of Sheffield in England and their colleagues have designed a drug delivery scheme that takes advantage of the natural attraction of macrophages to the oxygen - starved areas in tumors.

Copeland's team also noted that these mice suffered from a host of immune - related problems, the most crippling being a flood of macrophages — a type of white blood cell — damaging the lungs and other organs.

Previous studies indicated that microglia, a type of macrophage found in the brain, may have a role in the disease.

In a mouse model of heart failure, the researchers showed that blocking the bone marrow's macrophages from entering the heart protects the organ's beneficial pool of macrophages, allowing them to remain in the heart, where they promote regeneration and recovery.