Sentences with phrase «of metastasis»

«We propose that inhibiting miR - 194 could reduce rates of metastasis in patients with aggressive disease, but the development of a drug to achieve this goal is still a long way off.»

Using the MACC1 gene as biomarker, physicians can now for the first time determine the risk of metastasis in Klatskin carcinoma.

The follow - up studies at Sahlgrenska Academy have now found that antioxidants double the rate of metastasis in malignant melanoma, the most perilous type of skin cancer.

Malanchi and colleagues show that POSTN is expressed primarily in fibroblasts and to a lesser extent in endothelial cells but is not expressed in immune cells at sites of metastasis (Malanchi et al., 2012).

Researchers say they have identified a switch that makes dormant breast cancer cells that have traveled to the lungs swell to lethal proportions — completing the dreaded process of metastasis or cancer spread.

Its nontoxic B - subunit binds to the cellular toxin receptor, glycosphingolipid Gb3, which is highly expressed on human cancers and has recently been reported to be involved in the formation of metastasis in colorectal cancers.

«Previous studies have linked increased stress with accelerated onset of metastasis in some forms of breast cancer,» said Michelle L. Halls, Ph.D., a researcher involved in the work from the Drug Discovery Biology Theme at Monash Institute of Pharmaceutical Sciences at Monash University in Parkville, Victoria, Australia.

This «liquid biopsy,» described in a recent issue of the journal Nanotechnology, could become the basis of a simple lab test that could quickly detect early signs of metastasis and help physicians select treatments targeted at the specific cancer cells identified.

«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.

Of the tumor factors analyzed, the histologic subtype anaplastic carcinoma (P =.02), WHO stage I (P =.01), evidence of metastasis at the time of diagnosis (P =.004), and tumor size of 3 cm or smaller (P =.005) all significantly influenced survival.

Herbert Levine, a biophysicist at Rice University, and his late colleague Eshel Ben - Jacob of Tel Aviv University recently created a model of metastasis based on concepts borrowed from nonlinear dynamics.

Four compounds significantly inhibited key ovarian cancer cell functions in the early steps of metastasis at low doses.

Treatment with an investigational androgen receptor inhibitor significantly delayed the development of metastasis in patients with prostate cancer that had become resistant to standard androgen - deprivation therapy.

Successful treatment includes control of the primary tumor as well as prevention of metastasis.

«The RapidCaP system has revealed a specific role for Myc as a druggable driver of metastasis in prostate cancer,» says Trotman.

Much of our research is focused on immune regulation of metastasis by the innate immune system, but some of the other genes that we have identified appear to act directly on the tumour cells to prevent their ability to metastasise.

Emerging studies have also linked fructose to breast, gallbladder, bile duct and small intestinal cancers as well as increased chance of metastasis (cancer spreading to other areas of the body).

The prognosis is based on the severity of the disease and the extent of metastasis.

The detection of metastasis depends on imaging techniques that still can't detect micrometastases.

«At the earliest stages of metastasis, we already see astrogliosis and inflammation.

Chemotherapy is often recommended for dogs with a tumor that is too large to remove surgically, has spread to a lymph node, spread to other places or is a Grade III tumor with a high likelihood of metastasis.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

When the protein is present, these cells that start out round and stuck together in a pattern resembling cobblestones become irregularly shaped and tend to detach from the tumor site in an uncoordinated way — hallmarks of metastasis.

Now, researchers have developed a device that can detect even a single cell of any type of cancer circulating in blood, allowing early treatment of metastasis and new insights into cancer genetics.

Prior studies had shown that the metastasis of human melanoma cells in these mice is predictive of their metastasis in patients.

We are interested in two particular classes of inflammation - associated molecules as molecular determinants of metastasis: matrix metalloproteinases (MMPs) and interleukins.

Although science and medicine have made tremendous strides in early detection and successful treatment, breast cancer and melanoma still claim tens of thousands of lives a year — usually the end result of metastasis.

Tumors of these locations tend to have a decreased rate of metastasis compared to those of the limbs.

Additional diagnostic imaging of the chest will reveal the presence of metastasis in the lungs, and collecting cell samples from enlarged lymph nodes also will confirm metastasis.

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

«This study has provided strong evidence demonstrating that the molecular signature of metastasis exists prominently in the primary tumor,» says Mary Hendrix, a cancer researcher at the University of Iowa in Iowa City.

The results of this analysis identified a novel pathway and genetic mediator of metastasis for adenocarcinoma of the prostate, the androgen receptor gene.

«Our findings provide a rationale to pursue the new use of these «old» antidepressant drugs to benefit late - stage prostate cancer patients with signs and symptoms of metastasis,» said Wu, an assistant professor of pharmacy at WSU Spokane.

«Urologists tend to prefer to forgo adjuvant radiation therapy, because they fear the side effects, and radiation oncologists tend to prefer offering adjuvant radiation therapy because they fear the risk of metastasis [cancer spreading to other sites in the body],» Showalter said.

Ovarian cancer is difficult to treat because it's not often diagnosed until it has already metastasized to the peritoneum, liver or lung, the most common sites of metastasis according to the National Cancer Institute.

«Much of the epigenome gets reprogrammed right at the point of metastasis.»

«While CTCs are considered to be precursors of metastasis, the significance of CTC clusters, which are readily detected using devices developed here at MGH, has remained elusive,» says Shyamala Maheswaran, PhD, of the MGH Cancer Center, co-senior author of the Cell paper.

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

Researchers found that in the time between breast cancer patients being diagnosed with primary cancer and the diagnosis of metastasis, the breast cancer cells had gained genetic changes, or mutations, that increased the aggressiveness of the tumour.

«We are now applying this methodology to address specific clinically relevant questions about the biology of metastasis in larger numbers of patients.

Cell experiments revealed that the drugs activated the NRF2 signaling pathway, which triggered the expression of metastasis - promoting proteins.

On the other hand, uncontrolled migration of malignant cells results in cancer invasion of metastasis.

His laboratory at the German Cancer Research Center in Heidelberg and at the Medical Faculty Mannheim of Heidelberg University is studying the mechanisms of metastasis with the goal to develop more gentle supportive adjuvant therapies for tumor patients without detectable metastases following surgery of the primary tumor.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

After first verifying in their model that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas, the team implanted TRAIL - expressing stem cells into the brains of metastasis - bearing mice, which reduced the growth of tumors.

We also found that overexpression of miR7 in 231BrM cells decreased the tumor size by around 30 %, and this effect was blocked by ectopic expression of KLF4, indicating that miR7 does affect primary tumor but not to the level of metastasis (Supplementary Fig.