His research interests include new drug development against childhood cancers and role
of precision medicine in pediatric oncology.
The
promise of precision medicine is that when a patient is sick, a clinician will be able to develop a tailored treatment plan that takes into account that patient's unique biology.
While current
practices of precision medicine target a single cellular receptor, the new modular platform offers a robust biological approach — and may hold the key to the future of personalized medicine.
Stolid and practical, he's published more than 400 papers in peer - reviewed publications, toiling in the earthy
fields of precision medicine and computational biology.
Matching unique genetic information from cancer patients» tumors with treatment options — an emerging
area of precision medicine efforts — often fails to identify all patients who may respond to certain therapies.
«Once the ovarian cancer becomes drug resistant we can not cure it,» says Rodriguez a gynecologic oncologist who provides treatment to ovarian cancer patients and is director
of the precision medicine initiative at Rutgers Cancer Institute of New Jersey.
«To realize the benefits of the most recent progress in cancer genomics, clinical implementation
of precision medicine approaches is needed in the form of novel biomarker assays.
MEDPRIN is the first company in China to apply 3D bioprinting to the development of implantable medical devices and the
delivery of precision medicine.
This is consistent with the
idea of precision medicine, where you don't just look at age, you look at other things like functional status.»
While the
goal of precision medicine is to identify drugs that selectively affect disease - causing biomolecules, the process has typically involved time - consuming and expensive high - throughput screens to test millions of potential drug candidates to identify those few that affect the target of interest.
«In identifying a specific abnormality in a patient's cancer instead of the overall organ where it first presented, the opportunity exists to provide tailored therapies for patients,» notes Lorna Rodriguez, MD, PhD,
director of the precision medicine initiative at the Cancer Institute and professor of obstetrics, gynecology and reproductive sciences at Robert Wood Johnson Medical School.
In the recursive
circle of precision medicine, the expertise and experiential knowledge of doctors and clinicians will be supplemented with data produced by our living products and the analytic power of AI.
Another sub-analysis
of the precision medicine trials showed that while the use of both genomic and protein biomarkers improved outcomes, genomic biomarkers performed better.
Background: President Obama first announced the program back in 2015 to realize the
dream of precision medicine — that is, tailoring health care to an individual's genetics, lifestyle, and environment.
This work dovetails with the convergence of digital technology and healthcare and informs the
investigation of precision medicine that is the main theme of the Empowered Patient Podcast.
«It represents a model of collaboration between cancer centers, represents a monumental operational, technical and computational achievement and finally represents the
value of precision medicine in finding actionable mutations.»
He noted there is a huge unmet need for this
type of precision medicine among lung transplant patients, who experience the shortest of all survival rates, often running into transplant trouble within five years.
Study co-leader Wyndham Wilson, M.D., Ph.D., NCI Center for Cancer Research, added, «This is the first clinical study to demonstrate the
importance of precision medicine in lymphomas.»
«Not only could the test have a major impact on treatment of prostate cancer, but it could also be adapted to open up the
possibility of precision medicine to patients with other types of cancer as well.»
This opens up the possibility of achieving a
hallmark of precision medicine: targeted therapies for different «versions» of what was once thought to be a single disease.»
«Our research shows a new link between energy metabolism and inflammation, as well as giving early insights into the
fundamentals of precision medicine regarding the variation of the lipidome among individuals,» said Victor Darley - Usmar, Ph.D., Endowed Professor of Mitochondrial Medicine and Pathology at UAB and a co-investigator on the study.
Sitting in the front row were the two lieutenants who will carry out the
bulk of the precision medicine plan: National Institutes of Health (NIH) Director Francis Collins and NCI Director Harold Varmus.
Reference materials are critical to properly evaluate the next - generation of gene sequencing and genetic testing methods that will increase the reliability and
effectiveness of precision medicine (also known as «personalized medicine»), in which a person's genetic profile is used to create treatments and therapies unique to that individual.
Scientists and clinicians have increasingly tried to move away from simplistic racial and ethnic categories in disease research, the authors say, and — with the
rise of precision medicine — in clinical diagnosis and treatment as well.
As
part of the precision medicine initiative at the Cancer Institute of New Jersey, investigators — which include colleagues from Rutgers Robert Wood Johnson Medical School and RUCDR Infinite Biologics, the world's largest university - based biorepository, located within the Human Genetics Institute of New Jersey — wanted to define the relationship of ERBB2 alterations in the pleomorphic form of the disease.
This study is good example
of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.
The Oncology Research Information Exchange Network, or ORIEN, is the world's largest precision collaboration for cancer research, one that will enable researchers and clinicians to share data to accelerate the development
of precision medicine treatments.
NCI has launched a
series of precision medicine clinical trials since 2014, many genetically targeted therapies are currently available to cancer patients, and many more are expected to become available in the near future.
Precise knowledge of which stretches of the genome are pillars for stem cells, or metastasized tumor cells, or alzheimers - affected neurons, or [your cell line of interest], is the
foundation of precision medicine.
We will also look at how genetics and epigenetics influence the metabolic responses to exercise and discuss the potential implications for the coming
age of precision medicine.
Bringing on Rajkovic is a key step in hastening access to the
benefits of precision medicine for UCSF Health patients, said Institute for Human Genetics director Neil Risch, PhD, who co-chaired the search committee with Norton.