Sentences with phrase «of the cell cycle»

These are other proteins that are periodically formed and again broken down during the various phases of the cell cycle.

Such precise regulation of the cell cycle is lost in cancer cells.

Thus, the initiation and completion of each cell cycle phase has numerous checks and balances to ensure that DNA replication and chromosome separation occur properly.

His research interests are mechanisms of cell cycle control and initiation of DNA replication using biochemical and microscopy techniques.

Other studies have shown that the virus is capable of moving into brain cells, modifying the regulation of the cell cycle, and inducing their death.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

In order to figure out which phase that chem7 actually acts upon, Ueda and her team used two fluorescent proteins of different colors to visualize the process of the cell cycles in the root of Arabidopsis thaliana.

the metabolism of cancer cells, the responses of cancer cells to stress, and mechanisms involved in control of the cell cycle

Recombination refers to the formation of new combinations of genes naturally during meiosis, which is a stage of the cell cycle where chromosomes pair up and undergo exchange.

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

Ralf Kittler (Buchholz, MPG)-- «Functional genomic analysis of cell cycle progression in human tissue culture cells» (2006)

This molecule, called Rif1, ensures that only a fraction of the origins of DNA replication is activated at specified times of the cell cycle.

How the vital processes of cell cycle control (with the final event of cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.

As a result of the cell cycle synchronization, the sensitivity of the population changes over time.

Bacteria in the middle of their cell cycle were least affected by the antibiotic.

Palbociclib has been designed to thwart tumor growth by preventing key molecules of cell cycle progression from doing their job.

This blocks promotion of the cell cycle from the G1 to the S phase.

Topics spanned the entire field of cancer research, from molecular studies of cell cycle proteins to the role of vegetable consumption in cancer prevention.

«It completely turns upside - down what was thought to be a fundamental aspect of cell cycle progression in all cancer cells driven by one of the most common genetic pathways mutated in cancer, namely the p16 - cyclin D pathway.»

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

«New research paper challenges dogma of cell cycle control.»

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

«This allows us to quantitatively explore how these mechanisms work, and build a model that explains the variability within the data and the correlations between key properties of the cell cycle.

Check a review on integrative view of cell cycle control in E. coli by L. Dewachter, an article on the return of cultures in microbiology by V. Marx, an article on microbial altruism and cheating in social amoebas by S. Noh.

«Our results will serve as a useful foundation for, ultimately, understanding the molecular mechanisms and evolution of cell cycle control.»

[11] Since ABL activates a number of cell cycle - controlling proteins and enzymes, the result of the BCR - Abl fusion is to speed up cell division.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1 - Cdk4 controls glucose metabolism independently of cell cycle progression.

Miguel Turrero Garcia (Huttner, MPG)-- «Analysis of the cell cycle of neural progenitors in the developing ferret neocortex» (2013)

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

The Galli group studies the regulation of the cell cycle during development and tissue formation.

As most Cdk1 targets in the cell contain clusters of multiple sites, the regulation of cell cycle switch - points by Cdk1 might prove to be far more complex than generally anticipated, and it is possible that beneath seemingly random constellations of phosphorylation sites, an intricate signal processing logic is hidden.

To address the mechanism of growth inhibition by DDX3, we examined whether the promoter activity and the expression level of the cell cycle regulator p21waf1 / cip1 are regulated by DDX3.

I am a postdoctoral fellow with the Garner lab employing high - resolution microscopy in live bacteria and archaea towards the understanding of the cell cycle fate.

The large variability associated with the Timer mechanism is well known in the context of the cell cycle, and because of it, the Timer mechanism is not thought to be an appropriate way, on its own, to set stereotyped sizes (Amodeo & Skotheim, 2016).

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

Validation of a cell cycle progression score for five - year mortality risk in patients with stage I lung adenocarcinoma.

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

ActD has been shown to have a reversible cytostatic effect and the ability to arrest cells in both the G1 and G2 phase of the cell cycle [17].

BSI member and senior author, Dr Martin Turner, said, «Our findings shed light on the intricate control and coordination of the cell cycle and show that these binding proteins probably form part of a common mechanism to regulate quiescence, not just one specific to developing B cells.»

Such periodic behavior — a primitive version of cell cycle events — emerged in the system because the synthesized proteins could diffuse out of the compartment through the capillaries, mimicking natural protein turnover behavior in living cells.