Sentences with phrase «on immune cells»

The researchers have found a new calcium receptor on immune cells, acting as a mailbox to receive the parasite's orders for the cell to move.

That convinced me that zinc probably has a very important effect on immune cells.

Most famous is an antibody that targets a molecule on immune cells called PD - 1.

Researchers have developed an artificial structure that mimics the cell membrane, which can switch on immune cells to attack and destroy a designated target.

Also, contrary to expectations, the researchers said, bacteria that belonged to the same class did not necessarily have the same, or even similar, effects on immune cells.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells.

2B4 is an inhibitory molecule found on immune cells.

Damage to heart muscle caused by a heart attack turns on immune cells in the spleen that accelerate heart failure, according to a study in mice published recently by researchers at the University of Alabama at Birmingham in the journal Circulation Research.

By blocking a braking molecule on immune cells called PD - 1, nivolumab «takes the brakes off» the immune response, enabling a more powerful attack against cancer.

A new optogenetic technology developed by scientists at the University of Massachusetts Medical School and Texas A&M Health Science Center Institute of Biosciences & Technology, called optogenetic immunomodulation, is capable of turning on immune cells to attack melanoma tumors in mice.

«If you take an individual out of their poor social environment, at least in these adults, you're able to reverse the effects on their immune cell function.»

Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.

That gene, HLA - B * 5701, codes for a protein on immune cells that plays a central role in clearing the body of HIV - infected cells.

IgG subclass antibodies have a half - life of 21 days, and stick around on immune cells for about two to three months.

For instance, LKB1 also helped to repress cell surface markers on immune cells called dendritic cells that fueled the allergic reaction.

Essentially, it mimics the disease so that the immune cells recognize it, and the body stocks up on the immune cells with a barcode specific for that disease.

Another interesting observation, the researchers said, was that a single, little - known microbe, Fusobacterium varium, had, overall, the most powerful effect on immune cells across the board.

«This effort moves the community beyond the barriers of most previous molecular studies that focused exclusively on immune cells in the tumor microenvironment, providing a broader picture of how our bodies and immune system respond to the challenges of the presence of a particular tumor,» Dumeaux says.

Some have proposed that age - associated inflammation is caused by accumulating wear and tear on our immune cells, while others have suggested that it is caused by immune cells dealing with chronic viral infections.

Dawn Newcomb, an immunologist at Vanderbilt University Medical Center in Nashville, and colleagues examined the impact of testosterone on immune cells called group 2 innate lymphoid cells.

«Inflammatory diseases have long been blamed on immune cells that turn against the body.

To fend them off, it relies on immune cells called dendritic cells, which detect invaders and then call in the cavalry of T cells to attack.

Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.

Sialyl - Lewisx branches occur on some immune cells, helping direct them to certain locations in the body.

They found that the interaction of the C3dg fragments on affected erythrocytes and the binding domain for CR3 on immune cells can lead to phagocytosis and the rupturing of red blood cells in PNH patients.

Dr. Ruxandra Sîrbulescu analyzes flow cytometry data on immune cells used in a wound healing study.

They further show that, by regulating lipid metabolism, a cell is able to switch its immune phenotype by using transcriptional mechanisms and that the lipid environment has an important impact on immune cell function.

The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.

The inhibitory role of TIGIT on immune cells is also mediated in part by competition for binding of the same ligands to the T cell and NK cell co-stimulatory molecule CD226.

The first clinical trials of a new type of cancer treatment that releases the «brakes» on immune cells indicate that this approach enhances attacks on tumors while sparing the body's own tissue.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.

Like its more famous older sibling, CTLA - 4, PD - 1 is a protein found on immune cells that acts as a brake, or checkpoint.

AUGUSTA, Ga. — A receptor on our immune cells that can detect both the heat of a red chili pepper and the extreme physical heat of a...

On the morning of Monday, October 3, the Nobel Committee announced that immunologist Ralph Steinman had won the Nobel Prize in Medicine for his work on immune cells and a discovery that led to the first therapeutic cancer vaccine.

«The question of the decade,» Harrison says, has been what switches on the immune cells.

PD - 1 inhibitors fight cancer by blocking a «checkpoint» molecule on immune cells called T cells, which tumors use to shut down the immune cells.

New research shows that gene therapy can have long - lasting effects on the immune cells of HIV patients — a promising...

These are receptors on immune cells, which control for example effector T - cells by dampening their activation if damage to healthy cells is imminent.

Olefsky's group found it on immune cells involved in inflammation, as well as in mature fat cells, and they noted that it seemed to bind to omega - 3s.

THC activated two types of cannabinoid receptor on immune cells, called CB1 and CB2.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.

She says getting the correct dosage is all - important and plans to develop a biomarker to show whether the BCG is having even a subtherapeutic effect on the immune cells that target islets.

Abatacept is currently being used to treat autoimmune disease due to its ability to target B7 - 1 expressed on immune cells.

PD - L1 binds to its receptor PD - 1 found on immune cells to downregulate their activity.

Normally, when the cat protein finds its way into the blood of an allergic person, antibodies called IgE grab it and bind to receptors on immune cells.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promote anti-tumor immune responses, leading to tumor regression when inhibited with an adenosine A2A antagonist.