Sentences with word «oncogenic»
The word "oncogenic" refers to something that has the potential to cause cancer. It describes substances, genes, or conditions that can lead to the development or growth of cancer cells. Full definition
Michael A. Davies, M.D., Ph.D., Associate Professor and Deputy Chairman, Department of Melanoma Medical Oncology and Associate Professor, Department of Systems Biology, Department of Translational Molecular Pathology University of Texas MD Anderson Cancer Center «Integrated interrogation of oncogenic signaling pathways, immunology, and heterogeneity in cancer»
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«Integrated interrogation of oncogenic signaling pathways, immunology, and heterogeneity in cancer»
She has also shown that ARID1A mutations often co-occur with oncogenic mutations in the PI3K signaling pathway, suggesting a connection between these mutations.
«While we need to better understand how these abnormally regulated metabolites activate oncogenic proteins, our intriguing discovery suggests novel therapeutic targets for this disease,» says principal investigator and study leader Arnab Chakravarti, MD, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the OSUCCC — James.
Project Title: Functional in vivo screening of novel oncogenic driver mutations in a zebra fish melanoma model
Smyd3 function is required for the activation of oncogenic pathways, cell proliferation and epithelial to mesenchymal transition during tumorigenesis.
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.
Changes in this extracellular matrix can stiffen tissues and activate oncogenic signaling pathways, but cells may try to protect themselves by reorganizing their cytoskeleton and remodeling their attachments to the matrix.
In this study, we report the identification of MELK as a novel oncogenic kinase from an in vivo tumorigenesis screen using a kinome - wide open reading frames (ORFs) library.
«Our goal is to figure out how mithramycin interacts with oncogenic transcription factors,» says Tsodikov.
Interestingly, Yu and colleagues recently showed that knockdown of KLF4 decreased the proportion of cancer stem cells, whereas overexpression of this gene led to an increase in the cancer stem cell population, suggesting that KLF4 plays a strong oncogenic role in mammary tumorigenesis likely by maintaining stem cell - like futures of breast cancer cells (29).
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.
Activation of oncogenic Ras promotes tumor growth but also activates the cellular self - cannibalization process of autophagy that recycles intracellular components to help sustain that growth.
Having realized my passion for the same and determined about improvising medical treatment for melanoma cancer I am now working on «Functional in vivo screening of novel oncogenic driver mutations in a zebrafish melanoma model» under the guidance of Prof. Levesque Mitchell Paul.
«In an effort to expand therapeutic strategies beyond oncogenic targets to those not directly linked to cancer development, we have identified collateral lethal vulnerability in pancreatic cancers that can be targeted pharmacologically in certain patient populations,» said Prasenjit Dey, Ph.D., postdoctoral fellow in Cancer Biology and co-author of the Nature article.
Previous studies had supported the possibility of targeting oncogenic forms of Ras via KSR, but no pharmacological approaches had been reported until now.
Shin SS, Namkoong J, Wall BA, Gleason R, Lee HJ, Chen S. Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation.
Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.
Yeddula N, Xia Y Ke E, Beumer J, Verma IM (2015) Screening for Tumor Suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRAS in promoting lung adenocarcinoma.
imaginal epithelia, clones of oncogenic cells mutant for apico - basal polarity genes are actively eliminated when surrounded by wild - type cells.
¿ - herpesviruses, which include the human oncogenic viruses Kaposi Sarcoma - associated herpesvirus (KSHV) and Epstein Barr virus (EBV), are a family of large double - stranded DNA lymphotrophic viruses that are the causative agents of a variety of disorders, including lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers in mammals.
Both studies highlight the importance of microsatellite length in oncogenic function.
Here, we will explore how the tumor microenvironment promotes oncogenic progression, while protecting the tumor from therapeutic intervention.
Indeed, misrepair of DSBs can lead to inappropriate end - joining events, which commonly underlie oncogenic transformation due to chromosomal translocations.
Jeffrey A. Toretsky, M.D. Georgetown University Novel cancer therapeutics based upon oncogenic fusion - protein transcription factors
Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.
The goal of the study was to identify additional oncogenic alterations to provide a framework for further research and guide development of therapies.
Interestingly, however, a common oncogenic gene, MYC, was not sensitive to GSI.
These systems are, however, limited to a single oncogenic event and therefore fail to capture the complex repertoire of alterations of real tumours.
Gammaherpesviruses, which include the human oncogenic viruses Kaposi Sarcoma - associated herpesvirus (KSHV) and Epstein Barr virus (EBV), are a family of large double - stranded DNA lymphotrophic viruses that are the causative agents of a variety of disorders, including lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers in mammals.
Figure 2: A. Identification of enhancer hijacking mediating oncogenic overexpression in cancer genomes; B. IGF2 overexpression via de novo 3D contact domain («neo-TAD») formation in colon cancer mediated by recurrent somatic tandem duplications (Weischenfeldt et al..
«One theory is that the second, normal TEL allele is lost, and that at this point the fused TEL - AML1 protein becomes oncogenic.»
Furthermore; novel targeted therapies with MAPK pathway kinase inhibitors (KIs) have been developed thanks to the discovery that BRAF and NRAS mutations which are among the major oncogenic drivers of melanoma proliferation and survival [12].
Still, laying siege to cancer cells» supply lines may cast a wider net than targeted therapies aimed at rare oncogenic mutations.
Different levels of chromosome segregation errors have different consequences for tissues and organisms, ranging from oncogenic to tumor suppressive to lethal.
Effective preventive vaccines against the most oncogenic forms of HPV have been available for a number of years, with vaccination having the long - term potential to reduce the number of cases of cervical cancer,» said NCI Acting Director Douglas Lowy, M.D.
The team screened over 16,000 genes using just 100 litters of mice, and identified about 200 genes that were uniquely important to oncogenic growth in the skin.
Estrone's oncogenic metabolites, 4 - hydroxyestrone (4 - OH estrone, considered the most carcinogenic estrogen metabolite) and 16α - OH estrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metabolism.