Sentences with word «oncolytic»

Ongoing research aims to enhance the effectiveness of oncolytic virus therapy and broaden its applicability.

«So, we loaded MSCs with oncolytic herpes virus and encapsulated these cells in biocompatible gels and applied the gels directly onto the adjacent tissue after debulking.

4.1 HSV - based Oncolytic Viruses 4.1.1 Imlygic; talimogene laherparepvec; T - Vec; OncoVEX (GM - CSF) 4.1.2 G47Δ 4.1.3 HF10; TB - 1401 4.1.4 HSV1716; seprehvir 4.1.5 HSV - Rb - p450 4.1.6 BV - 2711 4.1.7 ONCR - 001

About Turnstone Biologics Turnstone Biologics Inc. is a biotechnology company focused on developing novel oncolytic viral immunotherapies for cancer.

6.4 Third Generation Oncolytic Virus Companies 6.4.1 Benevir BioPharm 6.4.2 Lokon Pharma 6.4.3 PsiOxus Therapeutics 6.4.4 Transgene

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells.

This work will have direct implications for designing clinical trials using oncolytic viruses for metastatic tumors in the brain.»

At a meeting last week of the International Society for Biological Therapy of Cancer in San Diego, California, Oncolytics Biotech of Calgary in Alberta, Canada, reported positive results from two trials of its drug Reolysin, which contains reovirus.

The FDA has approved its first oncolytic virus therapy talimogene laherparepvec (Imlygic), a drug for the treatment of patients with melanoma lesions in the skin and lymph nodes.

There are several different treatments being compared, including: surgery followed by vaccine - based immunotherapy, surgery followed by oncolytic virus therapy, surgery followed by IL - 12 gene therapy and biopsy followed by placement of a specialized catheter system that draws tumor cells out of the brain.

The use of viruses in cancer therapies — called oncolytic therapy — is still an emerging field.

They found that PD - L1 immune checkpoint blockade significantly improved the therapeutic efficacy of stem cell based oncolytic virotherapy in melanoma brain metastasis.

Phase I / II trials of such oncolytic vaccines are being planned for later this year.

OTTAWA, April 26, 2017 / CNW / - Turnstone Biologics Inc. announced today that treatment has been initiated on the first patient in the company's Phase I / II clinical trial combining its novel oncolytic viral immunotherapy agent, MG1 - MAGEA3, with pembrolizumab, an approved anti-PD-1 antibody.

Steven Russell, M.D., Ph.D., of the Mayo Clinic, and John Bell, Ph.D., of the University of Ottawa in Canada, each presented talks on how oncolytic viruses could be combined with vaccine approaches to produce more powerful results than vaccines alone.

Within cancer immunology, researchers are also focusing on oncolytic viruses.

Zika virus has oncolytic activity against glioblastoma stem cells.

The researchers» solution was to engineer oncolytic herpes viruses to express an additional tumor - killing agent, called TRAIL.

«Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing tumor cells.»

She founded the non-profit in 2011 and since then it has raised more than $ 370,000 for the Ottawa Hospital and Children's Hospital of Eastern Ontario for Viral Oncolytic Research.

Turnstone's platform generates a two - pronged effect on tumors by functioning both as a tumor - destroying oncolytic agent and as an immune - stimulating vaccine directed at specific cancer antigens.

Turnstone Biologics, a startup co-founded by FACIT, announced a research, option and license agreement with AbbVie Inc. for up to three of Turnstone's next - gen oncolytic viral immunotherapies.

The company manufactures and supplies essential renal and hospital products including equipment for acute and chronic dialysis; sterile IV solutions; infusion systems and devices; parenteral nutrition therapies; premixed and oncolytic injectables; biosurgery products and anesthetics; drug reconstitution systems; and pharmacy automation, software and services.

Shah and his team turned to mesenchymal stem cells (MSCs)-- a type of stem cell that gives rise to bone marrow tissue — which have been very attractive drug delivery vehicles because they trigger a minimal immune response and can be utilized to carry oncolytic viruses.

«So it's only when we combine oncolytic viruses with standard treatment that we can expect to see some very good effects.»

Narrowing the treatment to a particular tumor cell type makes for a more effective — and less harmful — oncolytic approach.

«We are currently developing similar animal models of brain metastasis from other cancer types as well as new oncolytic viruses that have the ability to specifically kill a wide variety of resistant tumor cells,» said Shah, who is also a professor at Harvard Medical School and a principal faculty member at the Harvard Stem Cell Institute.

Our team was instrumental in the development of talimogene laherparepvec, the first in human oncolytic virus therapy for patients with melanoma.

I'm a recurrent thyroid cancer patient undergoing oncolytic virus therapy, lcurrently ooking at Keytruda or Avelumab as next line of therapy once immunogenic cell death has occurred.

«This got my attention in part because this virus could be given systemically by intravenous injection, in contrast to most oncolytic viruses that are injected into the tumor itself, which obviously limits their therapeutic potential against cancers that are inaccessible or have spread to multiple sites in the body,» said McDonald, who is a member of the UCSF Helen Diller Family Comprehensive Cancer Center and the Cardiovascular Research Institute at UCSF.

Turnstone also is developing additional oncolytic virus strategies and immunotherapy combination treatments.

Sanford Health is the first in the nation to launch the Vyriad solid tumor oncolytic virus clinical trial.

The combination of the attenuated oncolytic virus talimogene laherparepvec (T - VEC) and the immune checkpoint inhibitor pembrolizumab shows activity and is well tolerated by advanced melanoma patients, according to a new study presented at the Society for Melanoma Research 2015 International Congress, held November 18 — 21 in San Francisco.

Vyriad is a clinical stage, biopharmaceutical company based in Rochester, Minn., that specializes in the development of powerful oncolytic virus therapies, using engineered viruses designed to selectively and rapidly destroy cancer.

CALM study: secondary endpoints of a phase II study of a novel oncolytic immunotherapeutic agent, coxsackievirus A21, delivered intratumorally in patients with advanced malignant melanoma.

Smith, B.F., Curiel, D.T., Ternovoi, V.V., Borovjagin, A.V., Baker, H.J., Cox, N., and Siegal, G.P. Administration of a conditionally replicative oncolytic canine adenovirus in normal dogs, Cancer Biotherapy & Radiopharmaceuticals Dec 2006, Vol.

M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction.

Acute Care Sales Specialist — American Pharmaceutical Partners, New Orleans, LA 2002 - Present Promote and market specialized line of generic injectable (IV) pharmaceuticals including oncolytics, critical care, anti-infectives, and other pharmaceutical products to hospital pharmacies, cancer centers, and Infusion centers.