Sentences with phrase «ongoing phase»

According to Onyx Pharmaceuticals, researchers participating in ongoing phase II trials of Onyx - 015 in different cancer types, including colorectal and pancreatic cancer, have observed a response to therapy in some patients.

And results presented at the conference from ongoing phase 1 and 2 trials showed that 38 of 50 patients treated with the drug had seen their tumours shrink to some degree.

Ongoing Phase 1b / 2 clinical trials combine entinostat with KEYTRUDA ® from Merck & Co., Inc. for non-small cell lung cancer, melanoma and colorectal cancer; with TECENTRIQ ® from Genentech, Inc. for triple negative breast cancer; and with BAVENCIO ® from Pfizer Inc. and Merck KGaA, Darmstadt, Germany, for ovarian cancer.

A larger ongoing phase 3 study (SONAR; ClinicalTrials.gov identifier NCT01858532) will shed more light on the kidney and cardiovascular protective effects of atrasentan.

Amgen has communicated with regulatory authorities and is in the process of notifying study investigators that treatment with ganitumab should be discontinued in the GAMMA trial, as well as a separate ongoing Phase 2 trial in locally advanced pancreatic cancer.

Should the slowing of clinical decline be confirmed in ongoing phase 3 clinical trials, it would provide compelling support for the amyloid hypothesis.

«While we are disappointed CheckMate - 026 did not meet its primary endpoint in this broad patient population, we remain committed to improving patient outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227 study exploring the potential of the combination of Opdivo plus [our other cancer immunotherapy] Yervoy for PD - L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD - L1 negative patients,» he added.

Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis.

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

But he expects this effect to show up in another ongoing phase III trial: CARE - MS II, the preliminary results of which should be available later this year.

The drug combination is being tested in an ongoing phase II clinical trial (NCT01896856) in a larger group of metastatic colorectal cancer patients at multiple institutions to determine the effectiveness of the dual therapy compared with chemotherapy regimens that do not include guadecitabine, says Azad.

The drug has already demonstrated safety in nonhuman primate trials, and the cardiovascular research might even be able to skip ahead to a larger phase II trial based on safety data from the ongoing phase I studies, Leeper suggests.

The ongoing phase I studies should help clarify this question.

An HIV - 1 version of the promising vaccine regimen is now being evaluated in an ongoing Phase 1 / 2a international clinical study.

Based on these pre-clinical data, the HIV - 1 version of this vaccine regimen is now being evaluated in an ongoing Phase 1 / 2a international clinical study sponsored by Crucell Holland B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

One such drug, the AstraZeneca compound AZD9291, is showing promise against resistant NSCLC in the ongoing phase 1 AURA clinical trial.

Ongoing phase I clinical trials have reported safe gene therapy treatment for the heritable Leber's congenital amaurosis (LCA), a rare degenerative disease which can cause near - blindness by young adulthood.

Intrathecal administration of an antisense drug, ISIS - SOD1Rx, has been shown to be safe and well tolerated in an ongoing Phase 1 study in patients with amyotrophic lateral sclerosis.

Celgene and Bluebird Bio have revealed updated data from an ongoing Phase I clinical trial of bb2121 at the ASH Annual Meeting in Atlanta.

The company is sponsoring the ongoing phase 1 clinical trial.

CAMBRIDGE, Mass., April 27, 2017 — Moderna Therapeutics, a clinical stage biotechnology company that is pioneering messenger RNA (mRNA) Therapeutics ™ to create a new generation of transformative medicines for patients, today announced positive interim data from an ongoing Phase 1 study of mRNA - 1440, an mRNA infectious disease vaccine against avian H10N8 influenza, demonstrating mRNA - 1440 induced high levels of immunogenicity, and was safe and well tolerated.

Asterias Biotherapeutics, Inc will present new 9 - month efficacy and safety data from their ongoing Phase I / IIa trial for OPC - 1 in a workshop and poster presentation.

First human proof - of - concept data published in Molecular Therapy: In April 2017, Moderna published in the journal Molecular Therapy positive interim data from a 100 µg intramuscular (IM) cohort from its ongoing Phase 1 study of mRNA - 1440, an influenza A virus subtype H10N8 mRNA prophylactic vaccine.

We learned more about the potential of PRX002 from a sneak peak at the interim results from an ongoing Phase 1b clinical trial of of PRX002 in PD patients (4) that were presented at the 13th International Conference on Alzheimer's and Parkinson's Diseases (AD / PD 2017) in April, (5) discussed by Prothena management and scientists in a concurrent conference call with investors, (6) and again presented at the 2017 International Congress of Parkinson's Disease and Movement Disorders in June.

FREMONT, Calif., Feb. 28, 2018 (GLOBE NEWSWIRE)-- Asterias Biotherapeutics, Inc. (NYSE American: AST), a biotechnology company dedicated to developing cell - based therapeutics to treat neurological conditions associated with demyelination and cellular immunotherapies to treat cancer, today provided additional data from the company's ongoing Phase 1 / 2a SCiStar study designed to evaluate the safety and potential efficacy of AST - OPC1 in the treatment of severe cervical spinal cord injury.

This approval clears the way to its manufacturer, ReNeuron Group plc (London, UK), to start treating patients in its ongoing Phase I / II trial with this new formulation.

In the ongoing Phase 1 study in children with SMA, all patients have completed dosing and ISIS - SMNRx was well tolerated as a single dose administered directly into the cerebral spinal fluid.

The choice to exclude all but stage IIIB / C patients in the ongoing phase III trial of PV - 10 [19] was influenced by these findings.

There are still five films to go before the ongoing Phase 3 wraps up for the successful superhero franchise series, but the film studio is already thinking several steps ahead, proving they have no plans of slowing down.

Windows 10 dropped off, but not dramatically, entering an ongoing phase of promotion from Microsoft.

The financing allows Arsanis to focus on completing its ongoing Phase 2 study for ASN100, a potential new standard of care for the prevention of Staphylococcus aureus pneumonia in high - risk, mechanically ventilated patients.

We recently shared the Real Estate Council of Ontario's (RECO's) submission for the ongoing phase 1 of the REBBA review.