Sentences with word «osteolytic»

To determine whether SOST impacts metastasis in animals, they modified a prostate cancer cell line to overexpress SOST, engrafted various cells lines onto immunodeficient mice, and quantified the rate of secondary tumors and of osteolytic bone lesions.

Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J).

These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis.

Sometimes biopsy of osteolytic lesions is needed for diagnosis.

We showed that ABL kinase activity was required for osteolytic metastasis of breast cancer cells and that depletion or pharmacological inhibition of these kinases impaired breast cancer metastasis to bone.

Osteosarcoma: Right radius tumor — aggressive mixed osteolytic and proliferative lesion.

In addition, with the help of Blaine Christiansen, an assistant professor in the Department of Orthopedic Surgery at UC Davis, they found that cells expressing more SOST induced significantly less osteolytic bone loss.

Tumor cells metastasized to bone modify the activity of these cells and, depending on the type of cancer, cause osteoblastic or osteolytic changes.

In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype.

In long bones, osteoblastomas are spindle - shaped osteolytic lesions that can break through the cortical bone with a moderate peripheral halo.

Tumor - derived Jagged1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

For most patients with breast cancer, bone metastases are predominantly osteolytic.

Regional radiographs revealed mixed osteolytic and osteoproliferative bone lesion associated with metaphyseal region of left distal humerus.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

Lesions can be either osteoproliferative (enlarged fuzzy areas on bone) or osteolytic (holes in bone).