Sentences with phrase «other flaviviruses»

The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors.

While this is the first study comparing the effects in mice of these mosquito - transmitted and tick - transmitted viruses in parallel, Miner says, past studies have raised the possibility of fetal infections with other flaviviruses besides Zika.

«These results support that the antibody - based assay that we have developed is highly effective in detecting both recent and past Zika virus infections and in discriminating Zika from other flavivirus infections,» said Davide Corti, senior vice president and chief scientific officer of Humabs BioMed.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in other flaviviruses by interfering with JAK - STAT signaling was present in both the Asian and American sequences from the 2007 - 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.

When the assay was run on patients infected with Zika virus and also on a control group of 540 patients infected by other flaviviruses or other viruses, plus healthy donors, the specificity was 95.9 percent.

In general, examining the potential effects of other flaviviruses on pregnant women and their developing fetuses is difficult, because outbreaks have been sporadic and less widespread than with Zika.

«Researchers are still working to understand precisely how Zika and other flaviviruses interact with an infected person's immune system,» she said.

(Other flaviviruses include the dengue and West Nile viruses.)

«It's the same technology WRAIR has used to successfully develop other flavivirus vaccines.»

The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity.

Scientists are most curious about what makes Zika virus different from other flaviviruses.

The new 3 - D structure, which was obtained using X-ray crystallography and electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of other flaviviruses — indicating it may interact differently with the members of an infected person's immune system.

This region varies not only among Zika virus strains but also in other flaviviruses, which suggests that differences in this region may influence virus transmission and disease.

Studies suggest that Zika - induced antibody responses may also cross-react with other flaviviruses, particularly dengue virus.

The high - resolution structure of the Zika virus showed that the overall virus architecture is similar to other flaviviruses such as the West Nile and dengue viruses.

Other flaviviruses, such as West Nile virus, are rapidly spreading around the globe.

The structure of mature Zika virus is similar to other flaviviruses, except in the region of a potential cell attachment site.

The structure reveals key interactions that probably contribute to the high catalytic efficiency of this enzyme relative to other flaviviruses, indicating promising starting points for drug design.

Assays already exist to detect Zika virus infection, but they either work only shortly after infection or are poor at differentiating Zika from other flaviviruses.

The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas with a high level of exposure to Zika virus and other flaviviruses.

«We've succeeded in developing the first ever antibody test for dengue infections that is capable of distinguishing between dengue and other flaviviruses,» says Dr. Sebastian Ulbert, Head of the Working Group on Vaccine Technologies at the Fraunhofer Institute for Cell Therapy and Immunology IZI.

The catch is that, although the antigens bind with the antibodies according to the lock and key principle, they almost always do so at the same site as all other flaviviruses.

A near - atomic level map of Zika virus shows its structure to be largely similar to that of dengue virus and other flaviviruses, but with a notable difference in one key surface protein, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Given the concerns for immune enhancement with other similar flaviviruses, like yellow fever and Japanese encephalitis, ZPIV will be tested in some volunteers who will first be vaccinated against one of these other flaviviruses.

ZIKV infection diagnosis relies on serology — which is challenging due to cross-reactions with other flaviviruses and / or absence or low titer of IgM and IgG antibodies at early phase of infection - virus isolation, which is labor intensive, time consuming and requires appropriate containment.

The current test suffers from cross-reactivity and a lack of precision in areas where DENV or other flaviviruses may coexist.

Since January 2014 I'm an instructor at the La Jolla Institute and continue to focus on characterizing T cell immunity against dengue virus and other flaviviruses.