She and her colleagues are now searching
for other small molecules that could be used to inhibit Wnt and promote FCSC growth.
Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and
other small molecule drug cadherin - 11 inhibitors.
The researchers suspect that this could open the door to the discovery of
many other small molecule - based quasicrystals, though it's unclear whether they will find practical uses.
«We can also potentially
identify other small molecules or recombinant proteins to reduce this interleukin 2 receptor gamma activity in the body — even eye - specific immune responses — that might reduce cell rejection,» said Lamba.
These effector proteins and
other small molecules in their spit cause the root cell to forego normal processes and create a huge feeding site called a syncytium.
«In addition to trapping small atoms, the cages could be used as molecular sieves for filtering carbon monoxide and
other small molecules, such as hydrogen and oxygen,» said first author Jian - Qiang Zhong, a CFN research associate.
Vividion will develop targeted protein degraders and
other small molecules in a new partnership with Celgene.
Until recently, scientists assumed that fatty acids, which are the main source of energy for heart, liver, and fat cells, simply diffused across the plasma membranes of cells, unlike glucose and
other small molecules that require specific transport proteins.
Finally, the strategy applied here for selective delivery of MK801 can be extended to
other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.