A new Brown University - developed technology called trans - Tango allows scientists to exploit the connections
between pairs of neurons to make such discoveries in neuroscience.
The worms would wander aimlessly if researchers either shut down the
specific pair of neurons or artificially canceled the magnetic field.
Psra - 11:: unc - 7S:: gfp was detected in AVB, ALA, the pharyngeal neuron I4, an
unidentified pair of neurons anterior to the nerve ring, and, in later larval stages, the VC motor neurons (but not A or B class motor neurons).
Moreover, because trans - Tango works by instigating the expression of genes in
connected pairs of neurons, it also has the potential to enable scientists to control circuit functions, says senior and corresponding author Gilad Barnea, PhD, an associate professor of neuroscience who began looking for a precise, reliable, and general way to visualize neural connections two decades ago.
For the first time, researchers at the University of Texas at Austin have pinpointed a
specific pair of neurons that act as a magnetic sensor in the simple worm C. elegans.
A pair of neurons in the CNS of flies controls and coordinates their ability to walk backward.
When data are fed into the network, setting off a cascade of firing activity, the algorithm determines based on the firing patterns whether to increase or decrease the weight of the connection, or synapse, between
each pair of neurons.
In particular, the receiving end of
a pair of these neurons — consisting of a little nub called a spine — gets a little larger.
A pair of neurons — called giant fibers — in the fruit fly brain has long been suspected to trigger escape.
In fact, the worms have
a pair of neurons called AWA dedicated to sensing it.
The brain is a complex network of interconnecting neurons and the junction between
each pair of neurons is made up of a synapse.