Sentences with word «panobinostat»

When the scientists placed DIPG cells in the pons area of mice they found that systemic injections of panobinostat inhibited DIPG growth and extended survival.

Olesen R, Vigano S, Rasmussen T, Søgaard OS, Ouyang Z, Buzon M, Bashirova A, Carrington M, Palmer S, Brinkmann CR, Yu XG, Østergaard L, Tolstrup M, Lichterfeld M. Innate immune activity correlates with CD4 T cell - associated HIV - 1 DNA decline during latency - reversing treatment with panobinostat.

Peter Atadja, a Ghanaian Drug Research and Development Scientist has led a team of researchers from Novartis Institute for Biochemical Research to develop Panobinostat (LBH - 589), an experimental drug for the treatment of cancers.LBH589 is a potent oral pan-inhibitor of class I, II, and IV histone (and non-histone) deacetylase enzymes (HDACs / DACs).

In petri dishes, they showed that panobinostat inhibited the growth of 12 out of 16 DIPG cell lines.

Dr. Monje, together with the National Cancer Institute - supported Pediatric Brain Tumor Consortium and Novartis, is planning to conduct clinical trials to test the safety and effectiveness of panobinostat for children with DIPG.

Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer.

Although the H3K27M mutation disrupts a different chemical tagging system, the scientists showed that panobinostat slowed the growth of a line of cells that had the mutation.

Studying H3K27M cells that developed resistance to panobinostat over time, they showed that GSKJ4, a drug that blocks the removal of methyl groups from histones, slowed tumor growth.

After reviewing the genetic and screening data they decided to focus on panobinostat, a drug designed to block multiple types of histone deacetylases.

Panobinostat also slowed the growth of DIPG cells that do not have that mutation.

The team tracked six of the drugs» dose - response relationship on DIPG cells and selected panobinostat for further study.

However, the team also found that a chemical called GSKJ4, which had previously been shown to inhibit DIPG cells, worked synergistically with panobinostat, with the two agents counteracting known mechanisms of epigenetic dysfunction in the DIPG cells.

The group of researchers from Aarhus University and Aarhus University Hospital has previously shown that the drug panobinostat can activate hidden HIV in the cells but for the first time the researchers have been demonstrated that it is possible to activate hidden virus to levels readably detectable in the blood by standard methods.

In a dish, DIPG cells that survived initial doses of panobinostat developed some resistance to the drug, the study found.

At least three different HDAC inhibitors, romidepsin, panobinostat, and SAHA, are under investigation as flushing agents.

Finally the scientists showed that panobinostat may work in combination with other treatments.

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

Standard treatments for symptomatic myeloma include chemotherapy with drugs like bortezomib (Velcade ®), lenalidomide (Revlimid ®), ixazomib (Ninlaro ®), and panobinostat (Farydak ®), autologous stem cell transplantation, and, in some cases, radiation therapy.

Panobinostat is an HDAC inhibitor used in the treatment of multiple myeloma and other plasma cell neoplasms.

Dr. Remiszewski is the co-inventor of panobinostat (Farydak ®), which the FDA approved in February 2015 for the treatment of multiple myeloma.

In addition to the planned clinical trial, which will test whether panobinostat alone improves survival time in children with DIPG, her team will also screen other drugs in combination with panobinostat.

The combination of CQ and panobinostat (pan-HDAC inhibitor) shows a significant advantage over CQ or panobinostat alone in repressing tumor growth and prolonging animal survival.