Sentences with phrase «patient cohorts»

Looking at blood samples from large patient cohorts proves especially interesting.

Identifying gene expression patterns in relation to the compound could facilitate the selection of the most appropriate patient cohorts for clinical development.

The number of patient receiving no treatment also increased from 7 to 40 percent for the youngest and oldest elderly patient cohorts in the study.

But more than that, it makes it possible to analyze a child's cancer data against both childhood and adult patient cohorts across all types of cancer.

We have analyzed samples from registries of patient cohorts available through the TEDDY study to describe the characteristic differences of the microbial communities between healthy individuals and T1D patients.

NYSCF actively partners with a Disease Foundation, which identifies an appropriate patient cohort from which NYSCF can collect skin biopsies or blood samples for iPSC generation.

The study patient cohort was organized by Hagiwara.

His research projects focused on the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

Co-author Subrata Sen, Ph.D., also a professor of Molecular Translational Pathology, notes, «These findings are a significant advance considering that there's nothing else available now to detect early stage pancreatic cancer that has gone through blinded validations in multiple patient cohorts.»

One of the toughest tasks is replicating these studies — an especially difficult proposition in diseases that are not overwhelmingly heritable, such as asthma, or ones that affect fairly small patient cohorts, such as certain childhood cancers.

The multicenter data presented included two patients cohorts who were enrolled across 18 sites.

An earlier analysis of diets in the same patient cohort by Fuchs and his colleagues found a significant link between coffee consumption and reduced recurrence and mortality in colon cancer.

Researchers at Henry Ford in Detroit analyzed data and shoulder function scores from two patient cohorts with osteoarthritis who had surgery: 262 patients under 65 and 103 patients older than 75.

We helped with the analysis of targeted 3730 sequencing of some candidate genes in a warfarin patient cohort, and uncovered another gene, (CALU, encoding calumenin) in which variants influenced warfarin dose.

Along these lines we will present proof of concept data for salivary DNA - methylation - and autoantibody - based biomarkers in a breast cancer patient cohort.

The aim of the Cardiogenomics programme in Maastricht is to exploit both the extensive patient cohort and novel genomics technologies to identify and functionally characterize genetic defects predominantly in inherited cardiomyopathies and heart failure.

Additional studies of different patient cohorts, including those from the US, are critical to better evaluate both a possible association of XMRV with CFS and a potential geographic link.

Development of new targets and pharmacological treatment strategies aiming to reduce CB sensory activity may thus improve outcomes in these key patient cohorts.

As the article explains, the initial patient cohort is being enrolled at the University of California, San Diego with the support of the UC San Diego Sanford Stem Cell Clinical Center.

[10] Complete responses (CRs) and partial responses (PRs) were reported in 3.2 % and 8.7 % of patients, respectively, with stable disease (SD) in 25 % of the two patient cohorts combined.

use the patient identification tool to identify the eligible patient cohort in their practice or service, assess individual patient eligibility and stratify their care needs to one of three complexity tiers according to their level of risk;

The turnkey functionality of this closed - system sorter decreases production time and offers the prospect of treating larger patient cohorts for a broader range of tumor types, requiring reduced personnel and resources.

«Sweden's strong track record in biobanking and clinical characterization of patient cohorts should allow important questions to be addressed related to the molecular mechanisms and diagnosis of human disease», says Kerstin Lindblad - Toh.

The study enrolled 100 patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 - patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months, with optical coherence tomography (OCT) performed in a subset of 30 patients at multiple time periods.

In the Dr. Yu's and Dr. Lichterfeld's labs, Dhohyung studied the host cyclin - dependent kinases and HIV - 1 reverse transcription, as well as the T cell intrinsic responses in various patient cohorts to HIV - 1 infections.

In this new work, BIDMC researchers and co-lead authors Sarinnapha M. Vasunilashorn, PhD, and Long Ngo, PhD, examined data from a patient cohort called SAGES (Successful Aging after Elective Surgery Study).

Although others had studied this effect before, this research had the largest patient cohort to date, and was also one of the first to examine patients treated with DHE.

Adams says more research is needed — such as identifying biomarkers, testing combination therapies and expanding clinical study to larger patient cohorts.

However, larger patient cohort studies are needed to confirm our results.»

«As a result of these high detection rates, PSMA also demonstrated a very high management impact in our patient cohort (63 percent), having an added value over FMC in 44 percent,» he continued.

Dr. Mitra undertook a large - scale bioinformatics approach to evaluate over 700 ovarian cancer molecular profiles from four patient cohorts.

«Our research shows that radiosurgery in this patient cohort does reduce the incidence of local recurrence, although the findings for overall brain control, overall survival and time until whole brain radiation therapy limit our ability to conclude an obvious clinical benefit,» said Dr. Mahajan.

New York City offers an ideal setting for our pursuits, a multicultural academic mecca providing a full spectrum of patient cohorts and diseases that is unparalleled anywhere in the world.

However, these approaches have not yet delivered all that they promised, partly due to the inherent genetic variability between patient samples, but also because the diagnostic / prognostic accuracy of the cancer signatures identified tends to be linked to the patient cohorts from which those signatures were obtained.

Significant inter-tumoral variation in collagen alignment was found, and notably high collagen alignment was observed in 12 % of the patient cohort.

Serotonin substrate supplementation, via L - tryptophan or 5 - hydroxytryptophan (5 - HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patient cohorts.