Sentences with phrase «patient tumors»
The phrase "patient tumors" refers to abnormal growths or masses of cells that are found in a person's body. These tumors are specific to each individual and require medical care and attention. Full definition
His analysis of all publicly available cancer mutations and integration with all solved computational models of human proteins has created a powerful roadmap for evaluating new mutations observed in patient tumors.
vicc.org
They used a newly established cell model that enables scientists to isolate cancer stem cells directly from patient tumor.
Both of these treatment strategies are tailored to the genetic makeup of individual patient tumors.
Predicine has launched a new liquid biopsy panel called PredicineATLAS, which covers 600 genes and offers a readout of patients tumor mutational burden to help inform and assess immuno - oncology treatment.
Establishing a repository of laboratory models derived from patient tumor samples that will enable researchers to more thoroughly investigate drug resistance
Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.
A major challenge in creating any type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient tumor cells into miniature tumor organoids in a petri dish.
A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.
The tracer was taken up by patient tumor tissue and appeared to differentiate levels of PARP - 1 expression; however, future studies should be aimed at determining if this tracer can be used to stratify patient response to PARPi therapy.
In early clinical trials of these drugs, we noticed that in some breast cancer patients the tumors didn't just remain the same size — as would be expected with drugs that interfere with cell division — but began to recede, sometimes quite dramatically, said Goel.»
In 63 percent of the patients, the tumors shrank by 50 percent or more, and in eight of these 19 responding patients the tumors disappeared altogether.
Like doctors who have been using VR to assist in surgeries and pinpoint ailments — by generating 3D models of real patient tumors from MRI scans, for example — science teachers are saying VR can help deepen understanding of subjects such as biology and anatomy, which require students to grasp the inner workings of cells and organs that are not visible to the human eye.
DiFeo is planning to test indomethacin's ability to specifically target ovarian cancer stem cells in patient tumors in a phase 1 clinical trial.
«In addition, it's another tool to uncover additional events that drive cancer and are specific to individual patient tumors, including the amount of the «rogue» protein, its specific form, or the type and extent of chemical modifications of the proteins that we know are treatable with approved or investigational drugs.
The aim of this collaboration is to identify innovative drug candidates and biomarkers for immunotherapy of various types of cancer, starting from patient tumor derived material.
This method will facilitate the analysis of patient tumors and the selection of the most appropriate therapy based on the individualized features of each patient's cancer subtype.
«In some patients the tumors never respond to aromatase inhibitors and just keep growing.
In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.
«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.
«With advances in cancer proteomics that increase the speed of measurement, we are moving toward a future that includes genomic and proteomic analyses of patient tumors.»
For this study, researchers relied on mice with group 3 medulloblastoma grown from patient tumors.
Palanichamy, Chakravarti and their colleagues conducted this study using 13 primary GBM cell lines derived from patient tumors, four commercially available GBM cell lines and normal human astrocyte cells.
Collaborations to access and profile immune cells in patient tumors are also underway to provide the relevant disease context for our current and future targets.
In parallel, Georgetown Lombardi's Stephen Byers, PhD, will grow the patient tumors in a novel «avatar» — zebrafish, to be used as a surrogate to predict response and determine resistance pathways.
In support of the second tenet, stem - like cells or CSCs that can initiate serially transplantable tumors in mice recapitulating the heterogeneous nature of patient tumors have been reported not only in leukemia (11 — 14) but also in solid tumors, including breast cancer (15), glioma (16), colon cancer (17 — 19), head and neck squamous cell carcinoma (20), and pancreatic cancer (21).