Sentences with word «pharmacodynamic»

Effects of breast pumping on the pharmacokinetics and pharmacodynamics of ethanol during lactation.

Investigators at The Ohio State University Wexner Medical Center explored blood SMN mRNA levels as a potential pharmacodynamic biomarker of an SMN - modulating therapy.

Pharmacokinetc and pharmacodynamics effects of 28 days of oral dimethandrolone undecanoate in healthy men: a prototype male pill.

Dr. Rudek studyies the pharmacokinetic - pharmacodynamic properties of anticancer agents, and her research is focused on oncology (preclinical studies and Phase I clinical trials / early phase drug development) and special populations within oncology (AIDS malignancy, and organ dysfunction).

Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats.

Safety pharmacology: Safety pharmacology deals with the specialisation in detecting the potential pharmacodynamic side - effects of new chemical entities.

Trial # 5: Combined autophagy and HDAC inhibition: A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of HCQ in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumor.

For the last 11 years, he's taught a weeklong workshop on advanced pharmacometric - pharmacodynamic data analysis at Cambridge University, which is an excellent networking opportunity.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

In simple terms, pharmacokinetics, PK, measures what the body does to the drug, while pharmacodynamics, PD, measures what the drug does to the body.

In 2011, he established the Immunotherapeutics Clinical Core, a specialized phase 1 outpatient unit at MSK that is focused on the conduct of novel immunotherapy trials, with a specific emphasis on pharmacodynamic biomarker identification.

Findings from a pharmacokinetic and pharmacodynamic substudy comparing the two dose levels will be presented at a later date.

Dr. Rudek is investigating the pharmacokinetic and pharmacodynamic behavior of anticncer gents and identify determinants that impact on the PK / PD variability of these agents with the hopes of individualizing therapy.

Palbociclib in Combination with Fulvestrant or Tamoxifen as Treatment for Hormone Receptor - Positive Metastatic Breast Cancer with Prior Chemotherapy for Advanced Disease: A Phase II Study with Pharmacodynamic Markers (TBCRC035)

The available data suggest that reversal of scopolamine - induced cognitive impairment is a viable model for predicting pharmacodynamic signals of cognition enhancing compounds in animals [91].

Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P - Glycoprotein Transport and the Pharmacokinetic / Pharmacodynamic Disposition of Dabigatran.

The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.

The ascending - dose, single - blind, placebo controlled, randomized trial will evaluate the safety as well as the pharmacokinetic and pharmacodynamic profile of DG041.

Bode - Boger S, Boger R, Galland A, Tsikas D, Frolich J. L - arginine - induced vasodilation in health humans: pharmokinetic - pharmacodynamic relationship.

Dr. Kern's research interests include keratoconjunctivitis sicca: epidemiology of clinical syndromes; avian and nondomestic animal ophthalmology; ocular pharmacodynamics; and genetics of ocular disease.

The primary objective of this study is to determine the maximum tolerated dose, dose - limiting toxicities, safe starting dose, and pharmacodynamic effect of TANOVEA ™ (rabacfosadine for injection) in cats with lymphoma.

In general, genetic polymorphisms result in alterations of pharmacokinetic and / or pharmacodynamics properties which are then reflected in therapy outcomes that range from potentially life - threatening adverse effects to inadequate therapeutic response.

Pelligand, L., King, J., Toutain, P., et al. 2012 «Pharmacokinetic / pharmacodynamics modelling of robenacoxib in a feline tissue cage model of inflammation.»

In conclusion, anthelminthics poorly fulfill the preconditions of a specific mode of anticancer action and availability of pharmacokinetic and pharmacodynamic data for a favorable repurposing as anticancer drugs.

Weikop, P.; Egestad, B.; Kehr, J. Application of triple - probe microdialysis for fast pharmacokinetic / pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain.

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.

To create a longer - lasting preventive therapy for severe hemophilia A-associated bleeding, a group of Japanese researchers launched a first - in - human Phase I trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ACE910, a bispecific antibody that mimics FVIII and works with other clotting factors to make the blood clot properly.

In particular, the team looked at pharmacokinetics, which influences the concentration of a drug reaching its target, and pharmacodynamics, which determines the drug response.

Study of the safety, pharmacodynamics and efficancy of KRN23 in children from 1 to 4 years old with X-linked Hypophosphatemia (XLH).

Predictive approaches to pharmacodynamics and pharmacokinetics in humans using nonclinical data sets, and developing safety biomarkers, are two areas ready for big scientific advances, says Jacobson - Kram.

«It isn't good enough to be trained in pharmacokinetics or pharmacodynamics or gene expression,» says DeGeorge.

This is a two - part Phase I - II, nonrandomized, open - label, single - arm, multi-center trial to evaluate the pharmacokinetics (PK), pharmacodynamics, toxicity, safety, and anti - tumor activity of MK - 3475 (also known as pembrolizumab) in pediatric subjects aged 6 months to less than 18 years of age with either advanced melanoma or a PD - L1 positive advanced, relapsed or refractory solid tumor or lymphoma.

A Phase 1 / 2a Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of PLX8394 in Patients with Advanced, Unresectable Solid Tumors

A Phase 1b / 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of AMG 232 Combined with Trametinib and Dabrafenib or Trametinib in Adult Subjects with Metastatic Cutaneous Melanoma

A Phase 1b / 2 Open - Label Study to Evaluate Safety, Clinical Activity, Pharmacokinetics and Pharmacodynamics of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies

Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies.

An Open - Label Multicenter Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B - 6527 in Subjects with Advanced Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

The second study, FIREFISH, is aimed to assess safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy in infants with Type I SMA.

SUNFISH is a two - part study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of RG7916 in Type II and III adult and pediatric SMA patients.

Well - characterized drugs may come with detailed knowledge of their pharmacodynamics, pharmacokinetics and side effects as well as with established regimens for clinical applications.

There are no any drugs with the same action mechanism, but Russian regulators wanted to know, for example, pharmacodynamics of the VEGF expressed from the plasmid.

Our pharmacogenomic research integrates high - throughput molecular analyses, pharmacokinetics, and pharmacodynamics to identify inherited germline and somatically - acquired tumor genetic determinants of drug effects in humans, with the long - term goal of optimizing drug therapy for individual patients.