Sentences with phrase «pharmacokinetic properties»
The phrase "pharmacokinetic properties" refers to how a medication is absorbed, distributed, metabolized, and eliminated by the body over time. It helps to understand how the drug behaves in the body and how long it stays in the system to determine the dosage or frequency of administration. Full definition
We then explored pharmacokinetic properties of RIPK2 inhibitor 1 in the sera of mice.
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«ISRIB shows good pharmacokinetic properties [how a drug is absorbed, distributed and eliminated], readily crosses the blood - brain barrier, and exhibits no overt toxicity in mice, which makes it very useful for studies in mice,» Walter said.
Subsequently, derivatives with pharmacokinetic properties better than the original compounds were synthesized.
«Perhaps giving a person the right dose, at just the right time, of a drug with just the right pharmacokinetic properties so its effect will wear off at the right time would work a lot better than bombarding the brain with benzodiazepines, such as Valium, that knock out the entire brain.»
The prototype of such bis - macrocycles, plerixafor, was used in a recent study as a starting point for structural modification, in order to identify compounds endowed with a similar antiviral activity and improved pharmacokinetic properties [94].
Replacement of the side chain with an isopropyl group led to the most potent compound 88, showing an IC50 of 2 nM for antiviral activity and suitable pharmacokinetic properties.
Successful approaches in structural manipulation led to a number of compounds with antiviral activities in the low nanomolar range and acceptable pharmacokinetic properties.
The physicochemical and mouse pharmacokinetic properties of BAZ2 - ICR were assessed.
Effects of the amino acid linkers on the melanoma - targeting and pharmacokinetic properties of 111In - labeled lactam bridge - cyclized alpha - MSH peptides.
Despite the disadvantages in terms of pharmacokinetic properties, these peptides have been instrumental in defining a basic pharmacophore model for designing smaller molecules.
The pharmacokinetic properties of J147 after a single dose of 20 mg / kg in mice show brain levels of about 600 nM at 2 h, over 10-fold above its EC50 in some cell culture neuroprotection assays [7], with a brain to blood ratio of approximately 0.5.
Southern Research has been awarded a new, five - year Indefinite - Delivery Indefinite - Quantity (IDIQ) contract from the National Cancer Institute to investigate the pharmacokinetic properties of antitumor and other therapeutic agents of interest -LSB-...]