Sentences with phrase «pharmacological inhibition»
"Pharmacological inhibition" refers to the use of drugs or medications to block or reduce the activity of a specific molecule, protein, or enzyme in the body. This inhibition is done intentionally in order to study the effects of blocking that particular target, often to understand its role in a disease or to develop potential treatments. Full definition
Cells were exposed to 2.0 and 3.0 Gy of radiation with or without prior pharmacological inhibition of ERK1 / 2, AKT as well as JNK pathways.
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First based on our completed genetic study we will test if pharmacological inhibition of an identified protein via direct eye injection can promote long distance optic nerve regeneration or whether, based on strong preliminary data, manipulation of another novel gene can induce such regeneration.
To complement the RNAi - mediated knockdown approach, we are also using pharmacological inhibition of MELK to evaluate the functional dependency of MELK in basal and luminal breast cancer cells.
Dr. Graupera's team found that either genetic or pharmacological inhibition of only one specific PI3K isoform, called p110α, is enough to induce tumor cell death and compromises vessel growth, which blocks tumor progression and metastasis.
Pharmacological inhibition of nutrient uptake decreased CML stem cell activity in vivo.
The results indicate that pharmacological inhibition of 12 / 15 - lipoxygenase reverses learning and memory impairments and reduces Aβ and tau neuropathology, even after their onset in aged mice.
Pharmacological Inhibition of Host Heme Oxygenase - 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes.
We showed that ABL kinase activity was required for osteolytic metastasis of breast cancer cells and that depletion or pharmacological inhibition of these kinases impaired breast cancer metastasis to bone.
Mice harboring a T106M mutation in p38alpha are resistant to pharmacological inhibition of LPS - induced TNF production and collagen antibody - induced arthritis, indicating that p38beta activity is not required for acute or chronic inflammatory responses.
These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis.