"Pharmacological intervention" refers to the use of medication or drugs to treat a medical condition or illness. It involves the use of specific substances that are designed to interact with the body's systems, targeting the underlying problem and helping to alleviate symptoms or cure the illness.
Full definition
Category winner — Simon Johnson For his essay «A Novel Target
for Pharmacological Intervention in an Untreatable Human Disease» in the prize category Translational Medicine
The four commonly used
pharmacological interventions in the figure are agomelatine, alprazolam, second - generation antidepressants and tricyclic antidepressants.
«Until now, several theoretical studies proposed that oxytocinergic system functions abnormally among patients with PTSD and that intranasal OT may potentially serve as an
effective pharmacological intervention for ameliorating symptoms of PTSD, but very few studies have examined the effects of OT administration among these patients, and to the best of our knowledge the effects of OT on empathy and compassion among patients with PTSD have never been assessed.
If the belief is that labor is happening to the woman, the focus is the uterus, not the woman, and the solutions considered are medical and
pharmacological interventions directed to the uterus.
A wide variety of
pharmacological interventions such as opiates, benzodiazepines, and prophylactic medications have been described that offer partial relief to migraine sufferers.
Even worse, a hallmark of Leishmania biology happens to be its capacity to adapt to a variety of unpredictable fluctuations inside its human host,
notably pharmacological interventions, with important consequences on disease outcome as demonstrated by the emergence of drug resistant clinical isolates.
Our results establish planarians as an experimentally tractable animal model for research into the pathophysiology of acute porphyrias, and potentially for the identification of
novel pharmacological interventions capable of alleviating porphyrin - mediated photosensitivity or decoupling dieting and fasting from disease pathogenesis.
Current studies in the laboratory are exploring in detail the functional role of this pathway in therapy resistant tumors, mechanisms pertaining to their activation in metastatic tumors, role in immune suppression, and
selective pharmacological interventions that may be effective to overcome resistance to conventional therapies.
Recommendations may
include pharmacological interventions, psycho - education, psychotherapy to address potential post surgery stumbling blocks, nutritional consultation, close aftercare monitoring, and / or bariatric surgery support group attendance.
Sixteen RCTs (reported in 42 publications) met inclusion criteria; seven focused on psychological interventions, eight focused
on pharmacological interventions and one examined both psychological and pharmacological treatments.
Two RCTs reported cannabis use outcomes
following pharmacological interventions: one in people with major depression, alcohol dependence and cannabis abuse diagnoses (n = 22; fluoxetine vs placebo) and one in people with schizophrenia and cannabis and / or cocaine use disorders (n = 28; olanzapine vs risperidone).
American Federation for Aging Research Fellow at the Albert Einstein College of Medicine in New York; USA From: Salt Lake City, USA Prize Category: Translational Medicine Essay: A Novel Target for
Pharmacological Intervention in an Untreatable Human Disease
Because of the negative side - effects
of pharmacological interventions, adults with dis - ordered sleep are increasingly seeking non-pharmacological sleep interventions such as natural supplements (e.g., melatonin, valerian, and tryptophan), meditation, and sleep hygiene programs (Henry et al., 2013).
Such inhibition of fertility suggests that testes are exquisitely sensitive to disruption of retinoid signaling and that these receptors could be targets
for pharmacological intervention of fertility (male contraception).
Pharmacological Interventions in Pregnancy, Postpartum and Lactation Evidence based research Evaluating Studies and Article Talking with families about medication
Both Gross and Willinger said they don't foresee a time when
a pharmacological intervention could be developed to prevent SIDS, however.
«If we can understand why maximal oxygen uptake is going down, that allows us to come up with targeted interventions, whether that be exercise or
pharmacological interventions.
«While much more research is needed, it is exciting to consider
that pharmacological intervention in these cellular processes might help slow or even prevent disease progression.»
«Optogenetic approaches are less harmful to the animals than surgical or
pharmacological interventions,» Hartung explains.
Accordingly, by performing genetic or
pharmacological interventions to limit TOR activity chronically, the researchers were able to prevent or reverse stem cell loss in tracheae and muscle of aging mice.
Noting that this anticipatory phase is often at the root of many people's sleeping problems, de Lecea suggested that the newly identified circuit could be a target for
pharmacological intervention to help people ease into sleep.
During functional analysis, some of the responses known to occur in the natural adult human heart were also elicited in hECTs through electrical and
pharmacological interventions, while some paradoxical responses of hECTs more closely mimicked the immature or newborn human heart.
«[I] t is exciting to consider
that pharmacological intervention in these cellular processes might help slow or even prevent disease progression.»
At the Newcastle University, he lead his group's work in these areas in cell and animal models of muscular dystrophy is concentrating on gene transfer,
pharmacological interventions and cell therapy.
Understanding the underlying mechanisms allows identifying putative sites for
pharmacological intervention and opens the prospect of engineering artificial molecular switches derived from the highly efficient systems that have evolved for cellular signal transduction.
While major depressive disorder is one of the most common mental disorders in children and adolescents, the use of
pharmacological intervention to treat it remains controversial.
On a societal level, we take responsibility for the fact that the diagnostic labels we have accepted, and
pharmacological interventions we have embraced, are harming children and that we have NO RIGHT TO ASK CHILDREN TO BEAR THOSE HARMS (my emphasis).
Unfortunately, this branch of medicine was severely suppressed by
the pharmacological interventions and died out until it resurfaced as a branch of medicine 20 years ago.
Pharmacological intervention is not the only answer to keep those glucose levels in a better, and non-diabetic range.
Conventional wisdom would put me on the fast track for some sort of
pharmacological intervention.
These findings indicate that aging dogs undergo changes similar to human inflammaging and offer the possibility of nutritional or
pharmacological intervention to delay or reduce these effects.
In most cases where medication is helpful,
the pharmacological intervention is used in conjunction with a behavior modification protocol.
Reviews with a favourable conclusion about psychological therapies (vs
pharmacological interventions) are at high risk for a spin in conclusions (OR = 8.31 (1.41 to 49.05)-RRB-, whereas favourable conclusions about effects of pharmacological interventions showed no spin in our sample (OR = 1.00 (0.16 to 6.14).