Sentences with word «phosphodiesterase»

In 2016, the U.S. Food and Drug Administration placed Viagra and other erectile dysfunction drugs collectively known as phosphodiesterase type 5 (PDE5) inhibitors on its watch list of medications with possible safety issues.

The inhibition of phosphodiesterase V leads to an increase in cGMP; this causes smooth muscle relaxation, which then leads to a decrease in blood pressure (hypotension).1 If the patient suffers from preexisting hypotension or is taking medications that can decrease blood pressure, sildenafil can intensify the effects.

The distribution of cyclic 3», 5» - nucleotide phosphodiesterase activity in rat cerebral cortex was determined by cytochemical methods.

Resveratrol ameliorates aging - related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

PRA in the Cardigan Welsh corgi, termed rod - cone dysplasia 3 (RCD3), is also caused by a mutation in a subunit of cGMP phosphodiesterase, this time the alpha subunit, which results in a disease with a comparable age of onset to RCD1 [4].

The finding was supported by a structural comparison of various members of the diverse phosphodiesterase family.

Among the top hits was a variant adjacent to the gene for PDE10A, a cyclic nucleotide phosphodiesterase involved in regulating smooth muscle contraction, including the muscles that surround the spleen.

Design and synthesis of fluorescent substrates for human tyrosyl - DNA phosphodiesterase I. Nucleic Acids Res.

Epimedium PDE - 5 Inhibitor Icariin from Epimedium extract is the only natural plant substance that has been observed to inhibit PDE5 (cGMP - specific phosphodiesterase type 5).

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The magnitude of this signal is restricted by desensitization of the receptors through their binding to β - arrestins and by cAMP degradation by phosphodiesterase (PDE) enzymes.

Most of the postsynaptic nerve endings showed phosphodiesterase activity.

The GTP - alpha subunit complex activates appropriate effectors, such as adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels.

The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane.

The team knew that Zucchini — and its analog in mice, called mouse Zucchini (mZuc, previously called PLD6 / MitoPLD)-- belongs to an enzyme family called phosphodiesterases.

A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.

Engineered deletion of the unique N - terminal domain of the cyclic AMP - specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

Zhang, R., Jha, B.K., Ogden, K., Dong, B., Zhao, L., Elliot, R., Patton, J.T., Silverman, R.H. * and Weiss, S.R. * Homologous 2», 5» - phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution.

Specifically, Sceletium tortuosum works by dual 5 - HT reuptake inhibition and PDE4 (phosphodiesterase subtype 4) inhibition which plays a crucial role in regulating cognition via the PDE - 4 - cAMP cascade signaling pathway involving phosphorylated cAMP response element binding protein (CREB).

Caffeine operated by blocking phosphodiesterase and increases cyclic AMP which had the same effect of increasing noradrenalin.

Phosphodiesterase inhibitors are in a class of drugs that include sildenafil (Viagra) and tadalafil (Cialis), both used to treat erectile dysfunction.

Recent studies have proposed as resveratrol may counteract aging by mechanism independent of the direct allosteric SIRT1 activation, such as inhibiting cAMP phosphodiesterases, elevating cAMP levels and indirectly increase in NAD + which finally leads to increase in SIRT1 activity 38.

The presentation, entitled «Ibudilast — Phosphodiesterase Type 4 Inhibitor — Bi-Modal Therapy with Riluzole in Early Cohort and Advanced Amyotrophic Lateral Sclerosis (ALS) Patients — Final Report and Future Directions «(Source) will be presented by principal investigator of the clinical study, Dr. Benjamin Rix Brooks, of the Carolinas HealthCare System's Neuromuscular / ALS - MDA Center at Carolinas HealthCare System Neurosciences Institute.

PDE4A5 is a type of phosphodiesterase (PDE) enzyme and chews up cAMP.

Substrate specificity of tyrosyl - DNA phosphodiesterase I (Tdp1).

Extracellular LPA is predominantly produced by autotaxin (ATX, also referred to as ENPP2 [ectonucleotide pyrophosphatase / phosphodiesterase family member 2]-RRB-, an ectoenzyme that was originally identified as a tumor - cell motility - enhancing factor (Stracke et al., 1992).

Using this material, the researchers were able to analyse in detail the response of rhodopsin, the pigment protein underlying vision, and phosphodiesterase, and for this reason they believe it can be useful in the field of optogenetics in the future.

Davies found that wrapping the nanoparticles around a phosphodiesterase inhibitor — otherwise known as Cialis — also produced an effective treatment.

Drugs tested by the U-M appear to correct the signaling pathway that is disrupted in muscular dystrophy at an earlier step than the phosphodiesterase inhibitors.

Other researchers have started investigating the possibility that phosphodiesterase inhibitors, which dilate blood vessels, can improve muscle function in people with DMD.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase — which mediate phototransduction, the process of converting light into an electrical signal.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase - which mediate phototransduction, the process of converting light into an electrical signal.

The phosphodiesterase 10 (PDE10) is highly expressed within dopaminoreceptive MSNs of the striatum and PDE10 inhibitors have been viewed as a potential treatment for schizophrenia.

Molecular cloning has demonstrated that dunce codes for the enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl cyclase; DCO codes for the catalytic subunit of protein kinase A, and CREB a transcription factor that is phosphorylated and activated by protein kinase A.

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

The phosphodiesterase 4D gene confers risk to ischemic stroke.

Reykjavik, ICELAND, October 3, 2008 — deCODE genetics (Nasdaq: DCGN) today announced the filing of an investigational new drug (IND) application for DG071, the company's novel small - molecule modulator of phosphodiesterase 4 (PDE4), with the US Food and Drug...

We are currently studying viral and host 2», 5» - phosphodiesterases that prevent activation of RNase L, thus allowing virus replication and viral pathogenesis.