Sentences with word «phosphotyrosine»
«Yingchun has developed methods to analyze both low and high abundant phosphotyrosine proteins from the pseudopodia,» says Klemke.
scripps.edu
In cells transformed by viral Src, or some other oncoproteins, the amount of phosphotyrosine shot up 10-fold compared to normal cells.
On the next slide I show you basically the key domain that's involved in this signaling interaction, so when the insulin receptor is phosphorylated, in order to recruit adaptors such as IRS - 1, it uses an important domain called the PTP domain, or phosphotyrosine containing peptides that can actually mediate this interaction, and lead to the interaction of these various molecules within the pathway.
«Phosphotyrosine became the thing to look for in your system because it was playing a role in cancer.»
After extracting all the proteins they could get, Hunter and his colleagues would measure the amount of phosphotyrosine.
STAT1 and STAT2 represent two of the seven mammalian STAT proteins that share several structurally and functionally conserved domains, including an NH2 - terminal coiled - coil region for interactions with other transcription factors and chaperone proteins, a phosphotyrosine - binding Src homology 2 domain required for receptor binding and STAT dimerization, and a COOH - terminal transcription activation domain (TAD) within which a highly conserved tyrosine residue is present.
(E) Left panel: cells were stimulated with MDP for 3 hours, and RIPK2 activation was monitored by a phosphotyrosine (pY) 474 RIPK2 antibody (in - house antibody) and phosphoserine (pS) 176 phosphorylation (Cell Signaling).
Calorie restriction increases muscle insulin action but not IRS - 1 -, IRS - 2 -, or phosphotyrosine - PI 3 - kinase.