Sentences with phrase «primary tumor»

Of these scans, 19 indicated the location of primary tumor.

Left - sided primary tumor location was associated with a nearly 20 percent reduced risk of death, according to the analysis.

The levels were highest in recurrent tumors compared with matched primary tumors.

While this method is consistently able to identify bone lesions, it often comes up with false positives and is not able to identify primary tumors.

Treatment of larger primary tumors generated a stronger immune response.

When cancers are found in their original location they are called primary tumors.

The cells in primary tumors are already established and are not affected by the inhibitors.»

In these circumstances, cells from primary tumors in breast, colon, prostate, or other organs invade lung tissue via the bloodstream.

Confirmation of primary tumor site was achieved in three patients by further imaging and in eight patients by histological examination.

«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»

The researchers then confirmed three properties of cancer: First, they determined that metastases originate along different paths, or lineages, within primary tumors, and spread in a «branched,» rather than a linear, model.

Specific projects include the use of gene expression signatures to predict recurrent rectal cancer, the study of gene expression changes in response to chemotherapy and radiation, differential gene expression between primary tumor and metastatic deposits, and analysis of expression patterns to provide more accurate cancer staging.

Additionally, they examine MMTV - PyMT control or POSTN null mice to test the effect of POSTN on primary tumor growth and metastasis (Figures 3A, 3B, and S13; Malanchi et al., 2012).

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

The prognosis for primary tumors which involve multiple lobes that are metastatic in nature is «Grave», as this form of liver cancer is incurable with no effective therapeutic option.

In a study of mice carrying human tumors, the therapy shrank the rodent's primary tumors while sparing healthy tissue; it also blasted cancer cells that had spread throughout the animals, reducing their number by up to 90 %.

Female mice carrying the MMTV - PyMT transgene that are either Postn + / + or Postn − / − will be examined for changes in primary tumor size and the number of spontaneously formed pulmonary macrometastases, which is a replication of the experiment reported in Figures 3A, 3B, and Supplemental Figure 13.

Chondrosarcomas are the second most common primary tumor of bone and account for 5 to 10 % of all bone tumors in dogs.

Nine additional patients had recurrence within the involved lobe (range, 0.1 to 5.9 years after SBRT), resulting in a five - year primary tumor and involved lobe (local) failure rate of 20 percent.

The presence of Sema3D also seems to be associated with the recurrence of pancreatic cancer in patients whose primary tumors were surgically removed, the scientists say.

Increasing expression of a chemical cytokine called LIGHT in mice with colon cancer activated the immune system's natural cancer - killing T - cells and caused primary tumors and metastatic tumors in the liver to shrink.

For this research, Ga - 68 DOTATOC, short for gallium - 68 1,4,7,10 - tetraazacyclododecane - N, N ′, N ′ ′, N ′ ′ ′ - tetraacetic acid - d - Phe1 - Tyr3 - octreotide, was administered to 36 patients with metastatic NET and unknown primary tumor site.

We also found that overexpression of miR7 in 231BrM cells decreased the tumor size by around 30 %, and this effect was blocked by ectopic expression of KLF4, indicating that miR7 does affect primary tumor but not to the level of metastasis (Supplementary Fig.

The study conducted at SciLifeLab shows that temozolomide itself not only is cytotoxically active against glioblastoma tumors but also against other types of brain tumors, such as medulloblastoma and metastases from other primary tumors.

Second, they found that metastases can genetically diverge from primary tumors early in cancer history.

The study concluded that black patients were 10 percent less likely to have primary tumor surgery, 17 percent less likely to receive chemotherapy and 30 percent less likely to receive radiotherapy.

To confirm this observation at the protein level, we analyzed primary tumors samples for MELK expression.

Figure 4 shows an example of heterogeneous PD - L1 staining of four corresponding primary tumor cores from a patient whose AQUA scores for the four cores ranged from 12.2 to 37.8.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Each method has strengths and weaknesses, but there is no single method that is able to successfully identify and monitor primary tumors, metastatic lymph nodes, and bone lesions.

«We reasoned that it would be easier to eliminate a small number of residual cancer cells by creating an immunostimulatory environment than it would be to treat an intact primary tumor, which has many means of evading an immune system attack,» Goldberg notes.

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

The approach to treating primary tumors within the colon and metastatic tumors in the liver continues to evolve; however, it typically involves chemotherapy plus surgical removal (resection) of both types of tumors.

Plasma samples also can not address the issue of expression heterogeneity (primary tumor vs. metastatic site (s)-RRB-.

Organoids from primary tumors generally don't grow; those from metastatic tissue sometimes do, but normal cells often outgrow cancer cells.

A higher temperature was better at eliminating primary tumors that were heat treated, but did not activate the immune system as well to find and attack metastatic tumors.

Brain metastases occur in a large number of patients with common cancers and are more prevalent than many primary tumors, including primary brain tumors, lymphoma and colon cancer.

Although the work is at the first stage of development, it excites team leader David L. Spector, Ph.D., because in mouse models of human metastatic breast cancer it has produced «differentiation of an aggressive primary tumor, redirecting it from a highly proliferative state, and reducing its metastatic activity by 70 percent.»

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

A total of seven patients went on to have primary tumors surgically removed, and another patient was treated with peptide receptor radionuclide therapy.

An investigational molecular imaging technique could be the key to finding the elusive primary tumor, say presenters at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

Indeed, treatment of mice with POSTN specific DNA aptamers, single - stranded DNA oligonucleotides designed to bind and inhibit POSTN, was shown to decrease primary tumor growth and metastasis in a xenograft model of mammary tumorigenesis (Lee et al., 2013).

PCR and deep resequencing of mutation - containing amplicons in the metastasis and primary tumor allowed for a frequency analysis of the 32 somatic mutations.

The Cancer Genome Atlas study encompasses more than 500 primary tumors representing the four intrinsic subtypes of breast cancer: Luminal A, Luminal B, Her2 - enriched, and Basal - like.

A CXCR4 antagonist CTCE - 9908 inhibits primary tumor growth and metastasis of breast cancer.