There was very little information about study methods and most of the results in the paper were not reported by
randomisation group.
In this new study, Professor Børge Nordestgaard and colleagues at Herlev Hospital, Copenhagen University Hospital, used genetics in a so - called Mendelian
randomisation study to explore this unsettled issue.
2 - arm RCT, with
individual randomisation; recruitment July 2000 - August 2002 at an urban USA hospital with BFI accreditation, n = 219
CTRU was responsible for informing CAMHS clinicians and family therapists of
randomisation outcome, to maintain researcher blinding.
Unclear risk of bias: there is no information
on randomisation method or it is not clearly presented.
low risk of bias (e.g. telephone or
central randomisation; consecutively numbered sealed opaque envelopes);
The occurrence of any depressive relapse / recurrence, and time
from randomisation to relapse / recurrence, will be assessed using the Longitudinal Interval Follow - up Evaluation, a form of the Structured Clinical Interview for DSM - IV (SCID)[41, 42] designed for longitudinal studies of depression.
The highlights of the roadmap are scheduled for September 2018, when the long awaited weapon slot and
weapon randomisation changes will kick in.
Baseline variables were measured using established valid instruments and were used as covariates to adjust for differences
between randomisation groups in some of the analyses in the paper.
The evidence of this study is intriguing, but without
prospective randomisation, we can not yet conclude that this is an effective strategy for any group of patients.»
There's the new Chaplain class to choose, more class customisation options, some new weapons and enemy types, and some
mission randomisation, but they don't alleviate the fundamental issues with the design.
Only five
randomisations per trait and breed were carried out and more might be desirable.
If you could do it directly with friends, maybe that'd be a laugh, but it sounds like it works via ranking, and
randomisation only.