Sentences with phrase «randomized phase»
The phrase "randomized phase" refers to a part or stage of a scientific study or experiment where participants are assigned to different groups (randomly) to receive different treatments or interventions. It helps ensure fairness and reduce bias in the study's results by distributing the participants randomly amongst the groups being tested. Full definition
Risk - Stratified Randomized Phase III Testing of Blinatumomab (IND # 117467, NSC # 765986) in First Relapse of Childhood B - Lymphoblastic Leukemia (B - ALL)
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«There is a significant possibility that local therapy, such as consolidative radiation, may become an important part of the management of limited metastatic NSCLC patients, but this validation must take place in randomized phase III studies.
Randomized Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis after Radiosurgery for Brain Metastases
Status: G100 is being studied in a fully - enrolled randomized Phase 2 trial in patients with follicular non-Hodgkin Lymphoma (FL) in combination with local radiation and Merck's anti-PD-1 agent, pembrolizumab, pursuant to a clinical collaboration with Merck.
Combining radiation therapy with chemotherapy for patients with limited metastatic non-small cell lung cancer (NSCLC) may curb disease progression dramatically when compared to NSCLC patients who only receive chemotherapy, according to a new randomized phase II clinical trial reported today at the 59th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Treating patients with high - dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to data from a prospective randomized phase II trial presented at ESMO 2014 Congress in Madrid.
She served on the End Point Response Committee for the Blood and Marrow Transplant Clinical Trials Network national randomized phase III clinical trial for treatment of chronic GVHD.
Soft Tissue Sarcoma Opportunity: in both our monotherapy single arm Phase 1 and combination randomized Phase 2 studies, we are focusing on two types of sarcoma where we believe there is significant unmet need: synovial sarcoma and Myxoid round cell liposarcoma.
In an international randomized phase III trial, patients with metastatic pancreatic cancer who were treated with a combination of albumin - bound paclitaxel (nab - paclitaxel [Abraxane ®]-RRB- and gemcitabine (Gemzar ®) lived longer than patients who were treated with gemcitabine alone.
This study, «Final Results of Local - Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer,» is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck cancer.
Status: CMB305 is currently in several stages of clinical development, including a monotherapy Phase 1 trial and a fully - enrolled randomized Phase 2 trial, primarilyin patients with two subtypes of soft tissue sarcoma (synovial sarcoma or myxoid / round - cell liposarcoma).
In Science Translational Medicine (DOI: 10.1126 / scitranslmed.aai8700) on February 15, his team published a related, randomized Phase II study in 100 people that showed that when humans were exposed to three rounds of the fasting - mimicking diet, their IGF1 levels decreased and their fasting glucose levels improved, among other findings.
A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen
The study was a randomized phase II trial testing whether the addition of local treatment, in the form of consolidative radiation therapy, to the standard treatment of systemic therapy improved progression - free survival for patients with limited metastatic NSCLC.
Next steps for this research include a larger, randomized phase III trial to test progression - free survival, as well as overall survival.
«Adding radiation to chemotherapy may dramatically improve survival for advanced NSCLC: Randomized phase II trial finds progression - free survival expectancy nearly tripled with addition of consolidative stereotactic radiation therapy for limited metastatic disease.»
The drugs were tested in a phase I combination study followed by a randomized phase 2 trial sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health.
Northwestern Medicine ® researchers are currently conducting the next phase of this research, a randomized phase II trial which will investigate if the HSPPC - 96 vaccine is safe and more effective when given with Avastin (bevacizumab).
Yet a randomized phase 3 trial was unable to identify those who benefited from cetuximab.
Weidhaas» team analyzed available samples from NRG Oncology RTOG of a randomized phase 3 clinical trial of cetuximab in combination with chemotherapy and radiation therapy.
Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC
A Randomized Phase 3 Open Label Study of Nivolumab vs Temozolomide Each in Combination with Radiation Therapy in Newly Diagnosed Adult Subjects with Unmethylated MGMT (tumor O -6-methylguanine DNA methyltransferase) Glioblastoma
A randoMized phAse II trIal of fulvestraNt wiTh or without Ribociclib After progression on AntI-estrogeN therapy plus cyclin - dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive, HER2 negative breast cancer (MAINTAIN Trial)
A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node - Positive or High - Risk Node - Negative HER2 - Low Invasive Breast Cancer
In a randomized phase 3 trial, adrenal cancer patients receiving the investigational drug linsitinib fared no better than patients receiving a placebo.
A Randomized Phase 3 Single Blind Study of Temozolomide Plus Radiation Therapy Combined with Nivolumab or Placebo in Newly Diagnosed Adult Subjects with MGMT - Methylated (Tumor O6 - methylguanine DNA methyltransferase) Glioblastoma
PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer
A Randomized Phase 2 Trial of Cediranib and Olaparib Compared to Bevacizumab in Patients with Recurrent Glioblastoma who have not received Prior VEGF Therapy
A Randomized Phase 2 Study of Atezolizumab in Combination with Cobimetinib Versus Atezolizumab Monotherapy in Participants with Unresectable Cholangiocarcinoma
A Randomized Phase 2 Trial of Cisplatin / Gemcitabine with or without VX - 970 in Metastatic Urothelial Carcinoma
A Randomized Phase III Study of Brentuximab Vedotin (SGN - 35, IND # 117117) for Newly Diagnosed High - Risk Classical Hodgkin Lymphoma (cHL) in Children and Adolescents
A Randomized Phase 2 Study of Cediranib in Combination with Olaparib versus Olaparib Alone in Men with Metastatic Castration Resistant Prostate Cancer
PELOPS: Palbociclib and Endocrine Therapy for Lobular Breast Cancer Preoperative Study: A Randomized Phase II Study of Palbociclib with Endocrine Therapy versus Endocrine Therapy Alone for Invasive Lobular Carcinoma and Invasive Ductal Carcinoma
The study enrolled 1,918 postmenopausal women in the randomized Phase 3 trial.
This randomized phase II / III trial studies how well pazopanib hydrochloride, combination chemotherapy, and radiation therapy work and compares it to radiation therapy alone or in combination with pazopanib hydrochloride or combination chemotherapy in treating patients with newly diagnosed non-rhabdomyosarcoma soft tissue sarcomas that can be removed by surgery.
In 2005, the chemotherapy temozolomide (Temodar ®) was approved to treat newly diagnosed GBM patients based on a randomized phase III clinical study that showed that it added 2.5 months to the median survival of patients.
The trial's randomized phase II segment is ongoing.
The U.S. drug maker released a statement on Monday saying that its Keynote - 010 study, a randomized Phase two - third trial, showed that patients who were taking two different doses of Keytruda (FDA - approved two mg / kg dose and treatment dose of 10 mg / kg given every three weeks) had longer survival compared to those who took docetaxel, the drug widely used for non-small cell lung cancer (NSCLC).
Immune Design entered into a clinical trial collaboration with Genentech, a member of the Roche Group, to evaluate the safety and efficacy of its CMB305 cancer immunotherapy product candidate combined with the investigational cancer immunotherapy atezolizumab in a randomized Phase 2 trial in patients with soft tissue sarcoma.
Primary overall survival from OPTiM, a randomized phase III trial of talimogene laherparepvec (T - VEC) versus subcutaneous granulocyte - macrophage colony - stimulating factor (GM - CSF) for the treatment of unresected stage IIIB / C and IV melanoma.
The drug, a monoclonal antibody called ipilimumab, is the first treatment of any kind ever shown in a large, randomized phase III clinical study (study MDX010 - 20) to improve overall survival in patients with metastatic melanoma who no longer respond to standard therapy.
A randomized phase II clinical trial on the ability of strawberries to reverse the progression to esophageal cancer.