Sentences with phrase «rational design»
Creating the electrodes needed for these technologies demands rational design, building the material rather than discovering it through trial and error.
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Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics — Casey M. Theriot — mSystems
The Meiler laboratory develops technologies to engineer protein, for example through assembly of large protein scaffolds from fragments (Fortenberry, C.; et al.; «Exploring symmetry as an avenue to the computational design of large protein domains»; JACS 2011; 133; 18026 & Eisenbeis, S.; et al.; «Potential of Fragment Recombination for Rational Design of Proteins»; JACS 2012; 134; 4019).
«Because thalidomide is now used for the treatment of multiple myeloma and leprosy, identification of its direct target may allow rational design of more effective thalidomide derivatives without teratogenic activity,» they report.
Cosford had been investigating ULK1 using medicinal chemistry and chemical biology, and had identified some promising lead compounds using rational design.
Furgeson and his colleagues said that zebrafish could be used to identify «nanomaterial characteristics that afford minimal or no toxicity and guide more rational designs of materials on the nanoscale.»
«We think we can use our molecular, rational design approaches to make a better flu vaccine for people who really need it,» says study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School of Public Health.
«Step toward rational design of catalysts: Better catalysts, made - to - order.»
My expectation and hope is that the findings from this study will help aid rational design of better drugs for the treatment of glaucoma.
There is no overarching rational design to the universe — no eternal reason - spider and spider - web (TSZ 186).
«Using structural biology technigues and rational design synthetic chemistry, SR10171 was constructed to engage the PPARγ protein in a unique way possessing an optimal balance with the receptor's other family member, PPARa, to treat diabetes and, at the same time, improve bone health,» Griffin said.
Computational models like that of M. genitalium could bring rational design to biology — allowing not only for computer - guided experimental regimes, but also for the wholesale creation of new microorganisms.
These derivatives were identified through rational design and analyses of structural and pharmacological data from early reported CXCR4 inhibitors [96].
Our Research Engine enables scientists across our ventures and partners to get large quantities of high - quality research mRNA in an expedited timeframe in order to undertake rational design of mRNA medicines.
Computational protein engineering: Bridging the gap between rational design and laboratory evolution.
We are interested on including solvent to qualitatively improve the accuracy of folding, docking and rational design methods.
De novo rational design of molecular scaffolds mimicking protein interactions for specific interference in cell signaling processes: We apply molecular modelling and computer simulation techniques for designing molecules with pharmacological / biotechnological interest.
On the other hand, rational design efforts to engineer artificial Kemp eliminases have resulted in limited success1, despite the simplicity of the targeted reaction.
Joining these three variants were an engineered back mutation (E82Q) variant denoted v0 and a forward mutation variant adding v3's E16G to v2 denoted v4 (Figure 1) The reverse and forward mutations were done to further characterize the performance of the DT40 evolution system and its advantages over prokaryotic based or rational design ones.
Hello, I'm writing in response to the recent review by Ian Cofre of Amir Nikravan's exhibition Rational Design at Nathalie Karg Gallery.
«While a handful of groups worldwide are developing artificial enzymes, they use rational design to construct the proteins on computers.
Now, scientists have shed light on how exactly one widely used group of motor oil additives prevents wear, a result that could lead to more rational design of new lubricants.
Rational design approaches to this problem have often used complex computational methods, have targeted simple model reactions and have typically led to low levels of catalysis1.
The perfected clock was a superb example of rational design, efficiency, organization, and mathematical order.
«This discovery opens the way for the rational design of a new generation of antipsychotic drugs, hopefully with more desirable effects and fewer side effects.»
The complexity of the brain has meant that most successful drugs for treating disorders like depression, psychosis and bipolar disorder were discovered by accident and trial and error rather than rational design.
He says, «All of the work on structure and function and the rational design of proteins can translate into improved products offering a better chance of success in gene therapy.»
«What is new is the rational design of the binding site of the MIP to maximise specific binding in the very complex aqueous medium [containing a mixture of sweat and deodorant formulation] in which the MIP needs to function,» says Haupt.
«Imaging of the joint could help evaluate the mechanism of a drug's therapeutic effect, and if a process turns out to be mediated by more than one chemoattractant, understanding the mechanism would allow the rational design of combination therapies to completely shut down critical steps in the process.»
«We gained this valuable knowledge through multidisciplinary basic research and approaching the problem with a rational design.»
«We hope that it will be possible to exploit the knowledge of the molecular basis of the Numb - Mdm2 interaction in the rational design of molecules that can mimic the crucial region in Numb and inhibit Mdm2 to relieve p53 dysfunction in Numb - defective breast cancers,» Di Fiore says.
Subsidiary mounds in the city «grid» seem to be placed according to a rational design.
Harris Wang, a lead author on the study, and Assistant Professor at Columbia University, added: «The use of the TFUMseq approach could allow the rational design of bacterial strains for various clinical applications, for example improving the ability of probiotic bacteria to colonize the gut, resisting colonization by pathogens, compensating for unbalanced diets, such as too much fat or sugar, or improving the function of the immune system to prevent diseases.»
This gives us better understanding of fundamental biology and should improve the rational design of drugs, which often target the inactivated state of channels» said Benoît Roux, PhD, professor of biochemistry and molecular biology at the University of Chicago.
The structural information is used for the rational design and development of small molecular inhibitors in combination with chemical biology approaches.
Ultimately, TFUMseq ‐ based studies could enable the rational design of probiotic or commensal strains for various clinical applications, such as resisting pathogen colonization, compensating for a high ‐ fat / high ‐ sucrose Western diet, or tempering host autoimmunity.
This offers the possibility for the rational design of materials that are tailored to specific applications, raging from drug delivery in healthcare to molecular electronics.
The rational design of nitric oxide selectivity in single - walled carbon nanotube near - infrared fluorescence sensors for biological detection.
«If we know more about the markers on the T cells that expand after PD - 1's inhibition is removed, that could facilitate the rational design of combination therapies,» says senior author Rafi Ahmed, PhD, director of Emory Vaccine Center and a Georgia Research Alliance Eminent Scholar.
«We anticipate that continued research will facilitate the rational design and synthesis of voltage - sensitive QD probes that can be integrated in a variety of imaging configurations for the robust functional imaging and sensing of electrically active cells.»
«These findings should lead to the rational design of R - ATAs based on this structural information to develop novel biocatalysts useful for the production of a diverse range of chiral amine compounds.
Toward the rational design of RO membranes, we performed contrast - variation neutron scattering measurements and atomistic molecular dynamics (MD) simulations on polyamide / water systems with various water contents and deuteration ratios.