Sentences with word «replicative»

«The effect of viral replicative capacity is just as big as, and independent from, the effect of well - studied protective HLA alleles, which influence whether someone is likely to become an «elite controller,»» says Daniel Claiborne, lead author and postdoctoral fellow.

CD8 (+) T cells that undergo extensive rounds of antigen - driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell - cycle arrest and a critically short telomere length.

Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae.

He has demonstrated that replicative stress accelerates ageing in mammals, and that inhibitors of ATR are future cancer drug candidates.

- Kristopher Hite — Dead Zone Judo - Buddhini Samarasinghe — The Hallmarks of Cancer: 4 — Limitless Replicative Potential - Scott Barry Kaufman — New Cognitive Training Study Takes on the Critics - Deborah Serani — What Adults Need to Know about Pediatric Depression - Ashutosh Jogalekar — Computational chemistry -LSB-...]

They inhibit viral infection by preventing viral entry into target cells and by blocking different stages of the viral replicative cycle for different viruses.

It is the hierarchical structure of nature that makes it unnecessary for us to imagine that the cosmos is simply a roulette wheel out of which a living cell with replicative capacities accidentally turned up all of a sudden one day long ago.

As demonstrated by Leonard Hayflick a half - century ago, human cells have a limited replicative lifespan, with older cells reaching this limit sooner than younger cells.

«This suggests lowering viral replicative capacity and the resulting immune activation might have benefits, in terms of morbidity and mortality, for individuals whether they remain treatment naïve or go on antiretroviral therapy.

Li and her colleagues also determined that the association of aggregates with mitochondria gradually declines in the mother budding yeast cells with advanced replicative age, likely contributing to their diminished ability to rejuvenate through asymmetric cell division.

Having less Pol III did not significantly increase replicative lifespan though; they did not bud more often over their lifetime.

A vaccine that targets qualities of the virus responsible for replicative capacity could have an important impact on disease progression and secondary transmission.»

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

To use viruses as delivery vehicles for gene therapy, researchers take all the harmful and replicative genes out of the virus and put in the therapeutic genes they want to deliver.

«These results reinforce our previous findings suggesting that interventions that affect replicative capacity can not only impact disease progression, but also the efficiency of transmission to other people,» says senior author Eric Hunter, co-director of the Emory Center for AIDS Research, Georgia Research Alliance Eminent Scholar and a professor of pathology and laboratory medicine at Emory University School of Medicine.

For instance, the conformational changes in the RNA polymerase complex occurred in the palm domain rather than the fingers, as in many other replicative polymerases.

For pronuclear transfer and the additional replicative difference between the mtDNA species, which by the way could go either way, it seems preferable to go as low as possible and stay below the 2 %, which fortunately is achieved for almost 80 % of the embryos.

Using replicative senescence as a cellular model, we will dissect the functions of ATR and ATM in the process of aging and in premature aging diseases.

Expression of certain viral oncogenes, such as the SV40 large T antigen (SV40 T - Ag), can elicit a significant extension of replicative life span, but these cultures eventually also cease dividing.

This may have important implications for cure strategies aimed at eliminating the viral reservoir, as individuals infected with low replicative capacity viruses may have smaller latent viral pools that may be easier to eradicate.

The Beloit Centre is home to nearly 700 employees and houses a number of research and development labs, customer collaboration areas, Kerry's Taste & Nutrition Discovery Centre and a fully equipped technical centre with manufacturing equipment replicative of both Kerry's and our customers» production environments.

People infected with viruses with high replicative capacity had more signs of acute inflammation in the first few months of infection.

The authors conclude that their six hallmarks — sustained proliferative signaling, evading growth suppression, resisting cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.

The mobile element that conveys methicillin resistance to staph includes a gene that encodes for Cch, an active helicase similar to other replicative helices.

Studies on MLSP demonstrated replicative senescence is caused by telomere loss, and telomere loss is - not - a clock counter but rather a dysfunction marker.

4: Naesens M. Replicative senescence in kidney aging, renal disease, and renal transplantation.

Bannard, O. and Kraman, M. and Fearon, D. T. (2009) Secondary replicative function of CD8 + T cells that had developed an effector phenotype.

The CMV - specific CD4 + T cells in elderly subjects had severely restricted replicative capacity.

Telomere length predicts replicative capacity of human fibroblasts.

The holoclone contains tightly packed small cells and has the greatest replicative capacity, and < 5 % of the colonies formed by the cells of a holoclone abort and terminally differentiate.

In contrast, the paraclone is a loosely packed clone of large cells with a short replicative life span — after < 15 cell generations, paraclones uniformly abort and terminally differentiate.

Inside the standard - width keepcase, which is housed in a largely replicative cardboard slipcover, one finds a six - sided fold - open insert which serves up four pages of production notes and reflections and a list of scene selections.

Smith, B.F., Curiel, D.T., Ternovoi, V.V., Borovjagin, A.V., Baker, H.J., Cox, N., and Siegal, G.P. Administration of a conditionally replicative oncolytic canine adenovirus in normal dogs, Cancer Biotherapy & Radiopharmaceuticals Dec 2006, Vol.

Finally, it would be ideal to have replicative data sets from multiple hospitals.

Loss of BRCA1 / 2 proteins results in DNA repair deficiency and replicative stress, leading to genomic instability and enhanced sensitivity to DNA - damaging agents.

The most well - known of these are so - called «senescent» cells, originally characterized by Leonard Hayflick as mitotic cells that reached growth arrest after a limited replicative lifespan (later associated with telomere attrition) under unphysiological conditions in culture.

Citation: A comprehensive analysis of replicative lifespan in 4,698 single - gene deletion strains uncovers novel mechanisms of aging

Duan also provided significant expertise from a long history of work on gene therapy for neuromuscular disorders.To use viruses as delivery vehicles for gene therapy, researchers take all the harmful and replicative genes out of the virus and put in the therapeutic genes they want to deliver.

Replicative differences are not an issue in PGD, as long as it is not related to the mutation itself, as apart from the mutation the mtDNA is completely identical.

Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63 - family of proteins in replicative senescence.

Within this span of time the thermodynamically improbable event of the living cell with replicative capacities could perhaps accidentally pop up in the cosmic lottery.

The sciences of physics and chemistry (or biophysics and biochemistry) can specify the atomic and molecular processes in the cell (as in its self - replicative «mechanism,» the DNA molecule or in protein synthesis out of amino acids).

Several physical measurements, including electron microscopy, assured us that our product was a closed loop coiled tightly around the virus - DNA template and that it was identical in size and other details with the replicative form of DNA that appears in the infected cells.