The phrase
"replicative capacity" refers to the ability of something (typically a living organism or a cell) to make copies of itself or reproduce. It indicates how well or efficiently the organism or cell can reproduce or replicate.
Full definition
It is the hierarchical structure of nature that makes it unnecessary for us to imagine that the cosmos is simply a roulette wheel out of which a living cell
with replicative capacities accidentally turned up all of a sudden one day long ago.
«These results reinforce our previous findings suggesting that interventions that
affect replicative capacity can not only impact disease progression, but also the efficiency of transmission to other people,» says senior author Eric Hunter, co-director of the Emory Center for AIDS Research, Georgia Research Alliance Eminent Scholar and a professor of pathology and laboratory medicine at Emory University School of Medicine.
«The effect of
viral replicative capacity is just as big as, and independent from, the effect of well - studied protective HLA alleles, which influence whether someone is likely to become an «elite controller,»» says Daniel Claiborne, lead author and postdoctoral fellow.
This may have important implications for cure strategies aimed at eliminating the viral reservoir, as individuals infected with
low replicative capacity viruses may have smaller latent viral pools that may be easier to eradicate.
People infected with viruses with
high replicative capacity had more signs of acute inflammation in the first few months of infection.
A vaccine that targets qualities of the virus responsible
for replicative capacity could have an important impact on disease progression and secondary transmission.»
The holoclone contains tightly packed small cells and has the
greatest replicative capacity, and < 5 % of the colonies formed by the cells of a holoclone abort and terminally differentiate.
«This suggests lowering
viral replicative capacity and the resulting immune activation might have benefits, in terms of morbidity and mortality, for individuals whether they remain treatment naïve or go on antiretroviral therapy.
Within this span of time the thermodynamically improbable event of the living cell
with replicative capacities could perhaps accidentally pop up in the cosmic lottery.
The gradual shrinking of telomeres negatively affects
the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.
The results confirmed the team's previous finding that
the replicative capacity of the newly established virus drives how quickly infected individuals» levels of CD4 T cells declined.