«Drug designers interested in using RNAi to treat disease have worried that if RNAi is part of the
mammalian response to viral infections, RNAi - based agents could compromise a human's immune response, producing unintended consequences.
In a nutshell, chronic disease such as Hashimoto's hypothyroidism develops as a result of an improper immune
response to a viral infection due to other predisposing factors.
In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells»
responses to viral infection, such as interferons.
Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune
response to viral infection.
What emerged from their work was the finding that the girl had inherited two differently mutated copies of the gene IRF7, which encodes a protein that amplifies the production of interferon, a critical part of the body's
response to viral infections.
Interest in studying tRNA fragments has been increasing swiftly as studies have shown that the fragments have regulatory roles and implicated individual fragments in cellular processes such as translation initiation,
response to viral infection, response to DNA damage, etc..
These APOBEC3 enzymes are an essential piece of the immune system's
response to viral infection, attacking viral DNA to cause disabling mutations.
Interferons are a family of naturally occurring proteins, produced in
response to viral infection.
Dr. June: It's never been demonstrated that non-engineered killer T cells could do this for cancer, however they exhibit similar proliferation in
response to viral infections.
Studies of the host
response to viral infection have historically focused on protein - coding genes, thus our understanding of how the non-protein-coding transcriptome, including both viral - and host - derived noncoding RNAs, impacts host - virus interactions is limited.
Using mouse models and human cell culture models, Dr. Shresta and her team dissect the protective versus pathogenic mechanisms of the immune system in
response to these viral infections.
Chakrabarti, A., Ghosh, P.K., Banerjee, S., Gaughan, C., and Silverman, R.H. RNase L triggers autophagy in
response to viral infections.
Interferons are produced naturally by the body in
response to viral infection.