Sentences with phrase «same mutation»

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

The researchers found evidence that the exact same mutation was occuring multiple times within the same patient.

«The very same mutations that were accepted by evolution when they were proposed, had they been proposed at a much earlier in time, they would have been deleterious and would have been rejected,» Plotkin said.

«We could even compare T cells from the two compartments targeting the exact same mutation and show that the TILs were more functional than the T cells we collected from the peripheral bloodstream,» says Harari.

What are the chances that another organism with the same mutations will find the other one before it dies to make the mutation become dominant in the DNA?

Other interesting points, blonde, and blue eyes are caused again by absence of pigment or lesser pigment, the mutation that turns of pigment production in the iris which also causes blue eyes is the same mutation that can cause albinism.

Though research suggests that the paternal - age effect is most significant for fathers over 40, younger fathers may also face an increased risk, possibly because spermatogenesis in very young fathers is more likely to result in the same mutations seen in older fathers.

But if mothers are tested, should they tell their kids, who have a chance of carrying the same mutation?

«Our study found that these same mutations halved the efficacy of flu vaccines in the past two seasons, and we expect they will lower the efficacy of the next vaccine in a similar manner.»

This alone would lead to the same mutation likely occurring independently multiple times.

«That's scary because it means that these cancers have access to many mutations and can find the same mutation over and over.»

Further testing showed that the woman's baby did not have the same mutation.

Excess expression of the sugar is caused by the same mutation that drives the growth of most DIPG tumors, known as the H3K27M mutation, the team found.

Géléoc and colleagues at Boston Children's Hospital studied mice with a mutation in Ush1c, the same mutation that causes Usher type 1c in humans.

The researchers also worked backwards through genetic time to demonstrate that the prestin gene evolved in echolocating bats and dolphins by the same route, gradually picking up the same mutations to get there.

«We still have a lot of questions to answer, including how these mutations interfere with craniofacial and reproductive development and why the same mutations can have such different effects in different individuals.

The same mutation that gives them their supremely adaptive brains has left them with extraordinarily vulnerable bodies.

The researchers posit that natural selection might favor mutations that protect against worm infection and that those same mutations might inadvertently increase the risk of other diseases, such as asthma.

So Barnes hypothesized that the mutations that help individuals fend off parasitic worms might be the same mutations that make them susceptible to asthma and allergies.

Collins calls these mutations «misspellings»; when a large number of people share the same mutation, they're known as single nucleotide polymorphisms (SNPs, pronounced «snips»).

David Hughes, a molecular biologist at Nottingham University in England, says the finding «raises a new puzzle»: Why does the same mutation leave some of its victims deaf, while those with Usher syndrome are struck deaf and blind?

Only one other child in the world, in Canada, has been identified with the same mutation.

The researchers found the same mutations in the tumour cells, but not in normal sperm - producing cells located nearby.

The mutation would only be visible if every cell has the same mutation.

For instance, DBA is often puzzling, because two family members may have the same mutation, but only one may be affected by the disease.

Even then, with a completely clean lab highly focused on meticulous technique, a new contamination struck in 2013 — something Myers identified when several different cell lines showed up with exactly the same mutation.

So the group grew new organoids, this time bearing the same mutations carried by babies with smooth brain syndrome.

In two situations, boys in unrelated families happened to share the same mutation.

«Currently, patients with a child with a disease caused by a de novo mutation are counselled that the risk of recurrence due to the same mutation in another child is between 1 and 5 percent, but if the disease is the result of a post-zygotic change, the recurrence risk will be extremely low,» says Dr Gilissen.

Around the same time, Fisher and his team engineered mice so that one copy of their FOXP2 gene carried the same mutation as that found in the KE family.

The group was surprised that so many small - dog breeds shared the same mutation.

All were discovered to have the same phenotype with the same mutation, which was located in the interferon - gamma (IFNGR) receptor, so the group began to explore what was causing this dysfunction.

«This is the first study to show in a mouse model with the same mutation that causes FOP in people that the drug palovarotene inhibits and abates extra-skeletal bone formation, yet is protective for normal skeletal bone growth,» said senior coauthor Eileen M. Shore, PhD, the Cali / Weldon Professor of Orthopaedics and Genetics at the Center for Research in FOP and Related Disorders in the Perelman School of Medicine at the University of Pennsylvania.

Although specific gene mutations have been identified in humans that can cause CCMs to form, the size and number varies widely among patients with the same mutations.

In a study to be published in the June 14 issue of Science, Storz and colleagues at UNL and Aarhus University in Denmark report that an individual mutation can be beneficial if it occurs in combination with certain other mutations, but the same mutation can detrimental to the organism if it occurs in other combinations.

Marasco's team found that the same mutations that enabled the MERS virus to escape neutralizing antibodies also weakened the virus» ability to replicate.

The researchers also compared pseudotyped Ebola viruses that matched the ancestor with ones with the same mutation, and found they preferentially infected cells from humans as opposed to the fruit bat species Hypsignathus monstrosus.

«We looked at about a dozen varieties, one from Asia, some from Europe, and all of them had the same mutation,» says Powell.

The researchers were puzzled when a puppy named Ringo, born in 2003, failed to develop severe symptoms, even though he had the same mutation on his X chromosome that prevented his brothers from building muscle.

But in 2010, Stephen Rossiter, an evolutionary biologist at Queen Mary, University of London, and his colleagues determined that both types of echolocating bats, as well as dolphins, had the same mutations in a particular protein called prestin, which affects the sensitivity of hearing.

Some of the bats had the same mutation that in humans is associated with language disorders.

The researchers first thought to look at Ashkenazi Jews when they discovered the same mutation in 10 unrelated Jewish families.

Because so many Ashkenazi Jews — who have Eastern European or German ancestry — have the same mutation, researchers can now think about testing on a large scale.

With the help of modern genetic technology and the resources of the International Rice GeneBank, which contains more than 112,000 different types of rice, evolutionary biologist Kenneth Olsen, PhD, associate professor of biology in Arts & Sciences at Washington University in St. Louis, has been able to look back in time and ask whether the same mutations underlay the emergence of the same traits in both cultivated and weedy rice.

Further, the child's father and paternal uncle had the same mutation, but did not experience any issues related to testes development or fertility.

In Chow's model, all glioblastomas arise as a result of the same mutations.

«What remains unclear is how the exact, same mutation can give rise to different subtypes of tumor.»

Jonathan Grima, currently a fourth - year neuroscience graduate student in Rothstein's laboratory, learned that this same mutation is also the most common cause of another disorder in which patients have Huntington's - like symptoms without having the causative Huntington's disease mutation.

As a result, it has been possible to induce the same mutation in a targeted fashion in other strains of fungus.