Sentences with word «senescence»
Senescence refers to the natural process of aging and deterioration that living organisms go through over time. It involves physical and biological changes that occur as cells and tissues become less efficient and lose their ability to function properly. In simple terms, senescence means getting old and experiencing the effects of aging. Full definition
This may well be more a sign of the times, a measure of the increasing interest in the research community directed towards the role of cellular senescence in aging, rather than something that arises organically.
fightaging.org
Again, then, there is significant evidence consistent with a role of cellular senescence in age - related lipodystrophy and lipoatrophy, and for the benefits observed in treated mice in these studies to translate into aging humans.
Cardiovascular disease and renal disease for example are accelerated in patients with diabetes and AGEs have been shown to induce senescence in cell types related to these diseases, such as endothelial progenitor cells, vascular endothelial cells and renal cells.
Furthermore, Dr. Loftus» group has demonstrated that reduced SOX10 expression in melanoma cells confers reduced cell proliferation, induces marks of cell senescence and leads to cell cycle arrest in melanoma cells.
Cellular senescence mediates fibrotic pulmonary disease.
Using replicative senescence as a cellular model, we will dissect the functions of ATR and ATM in the process of aging and in premature aging diseases.
The most striking chromatin modification is the formation of heterochromatic foci, termed as senescence associated heterochromatic foci (SAHF), often induced by the activation of oncogenes such as Ras.
Austad recalls one conversation in which Muller made an insightful connection about telomeres, the DNA - and - protein caps at the ends of chromosomes that shorten with every cell division, eventually pushing cells into a nondividing state called senescence.
«It was like an 80 - year - old recovering the function of a 30 - year - old,» says Rafal Smigrodzki, also at Gencia, who presented the results at the Strategies for Engineered Negligible Senescence conference in Cambridge this month.
We know telomere shortening drives cells into senescence [aging].
Our data identify a distinct senescence response and provide a mechanism by which mitochondrial dysfunction can drive aging phenotypes.
They engineered mice so that when cells flipped on a gene called p16Ink4a, a marker for senescence, the cell would also turn on the production of inactive cellular death genes, not normally produced by senescent cells.
Describing the inflammatory loop associated with senescence, Campisi said the results could impact current treatment of cancer patients.
But if this is true of «ordinary» species, what duration may we not look for in the case of Man, that favored race which, by its intelligence, has succeeded in removing all danger of serious competition and even in attacking the causes of senescence at the root.
Biological material (blood, bronchoalveolar lavage (BAL) and lung tissue biopsies) will be collected upon diagnosis and different senescence markers will be assessed.
And, unfortunately, negative senescence in humans remains elusive.
«DNA - damaging chemotherapy causes senescence, both to the tumor and its microenvironment.
That lockdown is for the greater good, says aging researcher Judith Campisi, who studies senescence at the Buck Institute for Research on Aging in Novato, Calif. «It's protective,» she says.
An alternative approach is to cause rapid cell aging and induce premature senescence, which we believe could become a new frontier in cancer drug development.»
«Clearly there are ways for natural selection to dramatically change how senescence happens,» Doak says.
Importantly, in contrast to p53 - dependent senescence induction, in the absence of p53 or in the presence of MdmX overexpression, FL118 promotes p53 - independent apoptosis.
Stay - Green mutants allow leaves to retain greenness during senescence.
It is thought that as we age, our immune system declines through a process called immune senescence — which makes it difficult for the body to defend itself from a variety of invading forces, including bacteria and viruses.
Triggering senescence in malignant cancer cells not only stops their uncontrolled replication, but causes them to die.
But problems like low replication rates and early senescence have impeded their efficacy in generating differentiated cells
In renal disease and after kidney transplantation, there is increasing evidence that replicative senescence pathways (p53 and p16) play a central role in disease progression and graft outcome, independent of chronological age.
The team showed that when a cell's DNA is damaged or an oncogene is activated (both of which can cause cancer), a normal cell triggers the digestion of nuclear lamina by autophagy, which promotes senescence.
The observation that p21 - / - and SV40 T - Ag - expressing cells behave identically with respect to life span extension as well as the high labeling index in the terminally nonproliferative state indicates that crisis is not a phenomenon induced solely by viral oncogenes, but a physiological state resulting from the bypass of normal senescence mechanisms.
«Our data suggest that senescence induction by inhibiting Shp2 or controlling its targets may be useful in therapeutic approaches to breast cancer,» the researchers conclude.
Working with researchers at the University of Tübingen, Germany, they mutated Arid1b in mice and human cells, and this stopped the cells from entering senescence.
In a human setting, it remains to be investigated whether cellular senescence plays an active or a bystander role in fibrogenesis and atrophy of renal tissue.
Calling quercetin and tocotrienols «promising natural compounds» researchers noted that they appear to satisfy all requirements for developing senescence - targeted health - prompting nutraceuticals.
Werner Syndrome (WS) is the segmental progeria considered to be most similar to natural senescence.
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.Proceedings of the National Academy of Sciences of the United States of America, 112 (52), 16006 - 16011.
In fall, leaf mercury is then transferred to the underlying soil system by leaf senescence.
Well, there are major pathways known to control senescence.
These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.
Although most scientists — including Rous — regarded research on senescence as a waste of time, Finch says he saw huge potential for developing rational strategies that would allow him to tease out underlying causes of aging.
Bypassing senescence is a hallmark of many types of cancer.
Seeking to better understand how cellular senescence contributes to the pathophysiology of aging.
There is satisfaction in knowing that the big, fake tough guy will likely live behind bars for a substantial portion of the time he has left before senescence and frailty set in.
A yeast peptide appears to reverse senescence — when follicle cells linger in a dormant state and cease to replicate.