The strategy is already helping fight cystic fibrosis, where a newly approved drug known as Orkambi helps stabilize the
proper shape of proteins that balance the flow of ions in cells lining the lung's airways.
Describing the three - dimensional
shape of proteins at atomic - level detail helps scientists develop highly detailed blueprints of the basic biology of these pathogens, leading to new interventions and therapies for the deadly diseases they cause.
Soaking raw meat in a salt water solution fundamentally changes
the shape of its proteins, allowing them to retain more moisture than they're able to naturally.
For instance, it could help us understand how
the shape of a protein determines how it interacts with and binds to a surface.
The most popular approach for determining
the shape of proteins was a technique developed in the 1960s called protein crystallography.
«Paired mutations: A new approach to discovering
the shape of proteins: A new study describes an innovative approach to identify the modular structure of proteins from their sole sequence information.»
Applying electron microscopy to biology was a challenge because the technique is done in a vacuum, which can dry out and distort
the shape of proteins and other biological molecules.
King said that by studying how
the shape of proteins change, researchers can determine how drugs bind and interact with cells.
«During an exchange of information,
the shape of the proteins changes.
The heat changes
the shape of these proteins, which vastly reduces their tendency to provoke allergies.
Knowing
the shape of every protein would yield new clues to their function and how they work, and ultimately provide thousands of potential new drug targets.
Now, it's the turn of the gem - cutters of biology — the people who decipher
the shape of protein molecules — and some are not too comfortable with the notion.
DNA contains the information that specifies
the shape of proteins.
The shape of a protein gives it its function.
But all it takes is a slight change in
the shape of that protein «lock» for the «key» to stop working, he says.
As the x-rays pass through and bounce off of atoms in the crystal, they leave a diffraction pattern, which can then be analyzed to determine the three - dimensional
shape of the protein.
«We've shown that a change in
the shape of a protein can perpetuate itself and be passed to other cells, without a change in DNA or RNA.
Figuring out
the shape of a protein can help scientists understand how it works and what goes wrong in disease.
Back to the assault — the antibodies are very specific to
the shapes of these proteins, but unfortunately these proteins also tend to look very similar to proteins within our own bodies.
Popović had made headlines around the world in 2011, after he and a colleague helped two graduate students design Foldit, an online, crowd - sourced game that challenged players, most of whom had little to no biomedical knowledge and most of whom played the online game across great distances, to learn about
the shapes of proteins and compete to fold them into the most efficient shapes.