For example, Lilly's Notice ignores the fact that its olanzapine patent was a selection (from a known general class of compounds), and that Lilly had specifically stated in its patent (to back up its selection) that olanzapine has «marked superiority and a
better side effects profile than prior known antipsychotic agents, and... a highly advantageous activity level.
«TENS likely has a placebo effect, but its safety and
side effect profile makes it an ideal tool in approaching chronic pain syndromes,» says Derk Krieger, MD, PhD, a neurologist at the University of Copenhagen in Denmark.
«Psychiatry has long struggled with the fact that, while lithium is highly effective for treating bipolar disorder, the narrow therapeutic window and
side effect profile often makes lithium both difficult and sometimes dangerous to work with clinically,» said Todd Gould, MD, of the Department of Psychiatry at the University of Maryland, an expert in the mechanisms of lithium and the neurobiology of bipolar disorder.
While biased agonists may be able to be used more safely at higher doses than other opioids, it remains to be seen how
other side effect profiles will be affected.
The agent, approved in 1995, has the benefit of a
reduced side effect profile compared to its traditional counterpart — delivery of free doxorubicin.
Whey is composed of the same basic proteins that are found in human breast milk and has the
same side effects profile as human breast milk.
Importantly, curcumin is not associated with the
undesirable side effect profile of conventional pharmaceutical medications such as corticosteroids and anti-inflammatories.
«Having Fanapt ™ available is a major help for our patients in offering an effective antipsychotic with an
excellent side effect profile across a wide range of major tolerability problems associated with other antipsychotic therapies.»
Thus, the first choice for treatment is stimulants due to their relatively
safe side effect profile however when misuse / diversion is a risk the choice of medications that are less abusable such as Daytrana (methylphenidate in patch form) or Vyvanse (lis - dexamfetamine - medication is oral however bound to lysine requiring stomach acid digestion in order to be activated).
And for contraceptives, there's an extra wrinkle: «You're developing products for very healthy people, so you have to make sure [the drugs] are incredibly safe, and
the side effect profile is acceptable,» says Diana Blithe, a biochemist and chief of the contraceptive development program at the National Institute of Child Health and Human Development in Bethesda, Md..
Regorafenib had a similar safety and
side effect profile to sorafenib, with hypertension, hand - foot skin reaction, fatigue and diarrhea all being significantly more common in patients taking the drug.
«
The side effect profile was much better as well, which gives hope to patients of having an improved quality of life while fighting the cancer.»