Sentences with phrase «signal transducer»
A signal transducer is a device or molecule that converts a signal from one form to another. It takes information or signals from one part of a system and translates or transforms it into another form so that the system can respond or understand it better. Full definition
The so - called Signal Transducers and Activators of Transcription, or STATs, are key components of many different signalling pathways.
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A novel disrupter of telomere silencing 1 - like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)- activated gene expression.
These transcription factors include signal transducers and activators of transcription, nuclear hormone receptors, Smad3, and the ubiquitous transcription factor Sp1.
The transcription factors specific to these pathways are also metazoan - specific (Tcf / Lef, Smads, CSL, Gli), whereas the cytosolic signal transducers generally have more ancient origins.
Antibody staining also shows increased phosphorylation of the Nodal signal transducer, Smad2, in lefty2 mutant embryos as compared to wild - type embryos (Author response image 1)(Dubrulle et al. 2015; Schier 2009).
Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC - 1 cancer cells.
This was the dilemma faced by scientists researching inhibitors of signal transducer and activator of transcription (STAT3), a protein that controls transcription by the STAT3 gene.
The STAT3 protein - it stands for «signal transducer and activator of transcription 3» - is a suspected factor in the relapse of nearly 40 percent of children with AML.
STAT3 stands for «signal transducer and activator of transcription 3,» a transcription factor (a protein) encoded by the STAT3 gene in humans.
The Drosophila melanogaster gene insulin - like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf - 2, a signal transducer regulating worm dauer formation and adult longevity.
STAT3 (signal transducer and activator of transcription 3) is a protein that activates the transcription of genes in response to IL - 6, a signaling protein released by cells in response to injury and inflammation.
My Honours project focused on genetically validating the Signal Transducer and Activator of Transcription 3 (STAT3) protein as a therapeutic target by using a novel transgenetic mouse model in which a short hairpin RNA directed against STAT3 can reversibly be induced by the administration of doxycycline.
Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which encodes a receptor tyrosine kinase), IL6 (which encodes interleukin - 6), MMP1 (which encodes matrix metalloproteinase 1), and TNC (which encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.
Here, we report that signal transducer and activator of transcription (STAT) 2 together with IFN regulatory factor (IRF)-9 can effectively drive the transcription of RIG - G gene by their functional interaction through a STAT1 - independent manner, even without the tyrosine phosphorylation of STAT2.
The first identified multimeric complex to recognize the ISRE consensus sequence is the IFN - stimulated gene (ISG) factor 3 (ISGF3), which is composed of the phosphorylated forms of signal transducer and activator of transcription (STAT) 1 and STAT2, together with IFN regulatory factor (IRF)-9 (4).
The LIM / Homeodomain Protein Islet1 Recruits Janus Tyrosine Kinases and Signal Transducer and Activator of Transcription 3 and Stimulates Their Activities
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN M
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN - gamma target genes
Using STED and PALM, Hjalmar Brismar's research group tries to understand the many functional aspects of Na,K - ATPase, the salt pump that is the major determinant of intracellular ion homeostasis and which has recently been shown to also function as a signal transducer.