A genetic approach in the mouse has been used to examine how
skeletal muscle stem cells are born, and how they acquire their identity.
Further research will focus on
generating skeletal muscle stem cells that can respond to continuous injury and regenerate new muscle long - term using the team's new isolation and maturation strategy.
One of the molecular mysteries hindering development of regenerative therapy for muscles is uncovering the precise genetic and molecular processes that
cause skeletal muscle stem cells (called myoblasts) to fuse and form the striated muscle fibers that allow movement.
Using
mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.
For years, scientists have been trying different methods that direct human pluripotent stem cells to
generate skeletal muscle stem cells that can function appropriately in living muscle and regenerate dystrophin - producing muscle fibers.
Claire Poulet (Ravens, TUD)-- «Electrophysiological properties
of skeletal muscle stem cells: functional evidence of their potential for cardiac differentiation?»
Manipulation of these genes in the mouse gives new insight into their role in the specification, proliferation and survival of
skeletal muscle stem cells.
But when even low doses of doxycycline were given to the recipients to turn on DUX4 in
the skeletal muscle stem cells, muscle regeneration was severely impaired.
Skeletal muscle stem cells unable to phosphorylate eIF2 exit quiescence, activate the myogenic program and differentiate, but do not self - renew.
Skeletal muscle stem cells propagated as myospheres display electrophysiological properties modulated by culture conditions.
Phrases with «skeletal muscle stem»