Sentences with phrase «specific gene expression»

By combining large datasets of protein - protein interactions and filtering by brain - specific gene expression in patients with and without Huntington's disease, the scientists narrowed potential interactors to 13 candidates, including 7 that are known targets in Huntington's disease.

This line of research will reveal how developmental signaling pathways interact with chromatin to establish specific gene expression programs.

Sex differences describe biology - linked differences between women and men, which are caused by differences in sex chromosomes, sex - specific gene expression of autosomes, sex hormones, and their effects on organ systems (Figure 1)(1, 3).

(A) depicts the repressive role of chromatin in maintaining tissue specific gene expression profiles in a chromosome.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up - regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes.

He extracted DNA from various species in order to clone fragments of genetic material to look for specific gene expression.

This paper was selected for the Trainee Paper Spotlight because it emphasizes the importance of miRNA on population specific gene expression patterns.

Sex - specific regulation and tissue - specific gene expression resolve how sex differences evolve from a shared genome

To carry out their census, the study team relied heavily on single - cell RNA sequencing (scRNA - seq), a suite of genomic techniques capable of identifying specific gene expression profiles within individual cells.

His research career has been principally concerned with understanding the mechanisms by which tissue and developmental stage specific gene expression is achieved and regulated with early work focusing on the regulation of the b - globin gene clusters.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

(2017) Enhancer transcription reveals subtype - specific gene expression programs controlling breast cancer pathogenesis.

We identified species - specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.

It is accepted that the regulation of adipocytokine secretion or the adipocyte specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.

Hippocampus - dependent memory and allele - specific gene expression in adult offspring of alcohol - consuming dams after neonatal treatment with thyroxin or metformin.

The Rho - kinase inhibition stimuli under low oxygen conditions (of 5 percent oxygen atmosphere), which is a condition corresponding to conditions in the body's cartilage, produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.

However, the study showed the one area of the brain with the most human - specific gene expression is the striatum, a region most commonly associated with movement.

Interestingly, Rho kinase inhibition under hypoxic conditions produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.

Characterized other proteins and pathways that modulate proliferation and differentiation of myogenic stem cells, hypertrophic growth of the heart, mitochondrial biogenesis and fiber type — specific gene expression in skeletal muscles.

Analyses were performed with 5 animals per group (control, 3 h of hypoxia, and 24 h or recovery after 3 h hypoxia) to decrease bias that may be introduced by donor - specific gene expression patterns.

Skeletal muscle differentiation entails the coordination of muscle - specific gene expression and terminal withdrawal from the cell cycle.

How developmental signaling pathways interact with chromatin to establish and maintain lineage - specific gene expression programs remains unclear.

Topics of interest include gene - environment interactions, genetic associations with asthma - associated phenotypes such as allergies and lung function, and the role of tissue - specific gene expression.

TiGER (Tissue - specific Gene Expression and Regulation) is a database that provides comprehensive information about postnatal human tissue - specific gene regulation, including expression (from EST studies) and regulatory elements.

It is accepted that the regulation of adipocytokine secretion or the adipocyte - specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.

Anthocyanin enhances adipocytokine secretion and adipocyte - specific gene expression in isolated rat adipocytes.

T binding to the AR converts the latter to a transcription factor; the T - AR complex then translocates to the nucleus and associates with DNA to regulate androgen - specific gene expression.1