Sentences with phrase «stem cell differentiation»

«I think it will mark a paradigm shift» in how scientists understand stem cell differentiation, he adds.

But scientists have not learned how to do this yet; so, studying stem cell differentiation is an active area of research.

The next step is to work out the underlying biological processes behind stem cell differentiation.

Stem cell differentiation Stem cell therapy has been growing increasingly popular recently due to it's regenerative effects on chronic problems.

The study, «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» was supported by the National Institutes of Health.

«Previous studies from our group show how the length of primary cilia play a role in stem cell differentiation, and this current study provides further insight.

With a better understanding of Chd1 function, it may be possible to improve the potency of some stem cells, such as in the creation of iPSCs, and it may also be possible to better direct desired stem cell differentiation for potential clinical applications downstream.

Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: «We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors.

By using the nanocomplex in conjunction with computer programme codes and imaging software, the researchers were able to follow how mRNA expresses itself during neural stem cell differentiation.

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation towards authentic DARPP - 32 + medium - sized spiny neurons

«This new understanding of the role played by scrawny may make it easier to expand stem cell populations in culture, and to direct stem cell differentiation in desired directions,» says Spradling.

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.

The study, which shows how new biomaterials can take the guesswork out of identifying factors that drive stem cell differentiation, appears on July 27 in Chem — Cell Press's first physical science journal.

«We're excited about the application of CombiGEM to probe complex multifactorial phenotypes, such as stem cell differentiation, cancer biology, and synthetic circuits,» Lu says.

Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.

With these findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem cell differentiation which could be used for beta cell replacement therapy in diabetes.

Confocal microscopy image showing a cross-section of a 3D - printed, 1 - centimeter - thick vascularized tissue construct showing stem cell differentiation towards development of bone cells, following one month of active perfusion of fluids, nutrients, and cell growth factors.

The pervasive vasculature facilitates stem cell differentiation by enabling delivery of cell growth factors throughout all areas of the tissue.

The findings are reported in the article «A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential» published online December 15 in Genes & Development.

«This new core laboratory will apply an array of the most promising technologies in the world for controlling stem cell differentiation, delivering stem - cell based therapies, scaling up cell production, and engineering replacement tissues,» said Andrew McCulloch, chair of the Department of Bioengineering.

All the interdisciplinary skills and knowledge he had gathered during his scientific training — which had covered biochemistry, biotechnology, biomaterials, and stem cell biology — put him «in a very advantageous position to address this question» of how to develop nanoparticles that could modulate stem cell differentiation on demand, he says.

Adds Pennacchio, «The range of biologically or disease - relevant enhancers that SIF - seq can be used to identify is limited only by currently available stem cell differentiation methods.

The study also found that in addition to its role in determining the sex of somatic cells, Sxl regulation by m6A is required to initiate germline stem cell differentiation for developing eggs.

[Praveen R. Arany et al, Photoactivation of Endogenous Latent Transforming Growth Factor — β1 Directs Dental Stem Cell Differentiation for Regeneration] Could a light - based treatment for cavities and chipped teeth eventually be in the offing for people?

«Transforming plant cells from generalists to specialists: Proteins team up to trigger stem cell differentiation in plant roots.»

The scientists found that celecoxib directly increased stem cell differentiation into keratinocytes — skin cells required for wound healing.

The research is titled «Transcription, Signaling and Metabolic Transitions During Human Spermatogonial Stem Cell Differentiation.»

A cell's microenvironment, the network of proteins and polymers that surrounds and connects cells within tissues, impacts a range of cellular behaviors, including stem cell differentiation.

This is the first time we've observed how matrix stress relaxation impacts stem cell differentiation in 3D.»

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

which is focused on mouse models of adult stem cell differentiation and tissue regeneration.

Fernando Ugarte Verdugo (Roesen - Wolff, TUD)-- «Role of Notch signalling pathway in human mesenchymal stem cell differentiation» (2009)

Haematopoietic stem cell differentiation promotes the release of prominin - 1 / CD133 - containing membrane vesicles - a role of the endocytic - exocytic pathway.

A cell therapy is a treatment that utilizes primary cells, stem / progenitor cells, or stem cell differentiation derivatives to replace or repair damaged organs / tissues.

The researchers found, however, that anterior escort cells — like cap cells — anchor the stem cells and produce signals to repress stem cell differentiation.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

However, said Singh, how these two factors govern stem cell differentiation was a mystery.

The regenerative biology team at the Morgridge Institute for Research, led by stem cell pioneer and UW - Madison professor James Thomson, is studying whether stem cell differentiation rates can be accelerated in the lab and made available to patients faster.

Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of abnormal tumor stem cell differentiation (9).

A protocol describing the use of a recombinant protein - based, animal product - free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies.

Paraoxon and pyridostigmine interfere with neural stem cell differentiation.

«Tuned gels reveal molecules that drive stem cell differentiation.»

Hundreds of such microarrays were required in the study to cover the entire genome in different time points during stem cell differentiation.

Past work, she notes, hinted that the qualities of the surface on which a cell lands could exert an influence on cell fate, but the idea was never fully explored in the context of human pluripotent stem cell differentiation.

To bypass the challenge, the team relied on their complementary expertise in genome engineering, stem cell differentiation into neurons, and genomic analysis of alternative splicing.

The findings of the scientists of the Institute of Diabetes and Regeneration Research (IDR) at Helmholtz Zentrum München (HMGU) provide new insights into the molecular regulation of stem cell differentiation.