While scientists have long known that a group of transcription factors are needed
for stem cell maintenance, the sheer number of possible interactions among them has made the question of which are essential too complicated to address in the laboratory alone.
Furthermore, POSTN was reported to bind to Wnt ligands, leading to an increase in Wnt signaling in CSCs, a known regulator
of stem cell maintenance in a variety of tissues (Malanchi et al., 2012).
Research Paper Role of TRF2 in efficient DNA repair, spheroid formation and
Cancer Stem Cell maintenance Arka Saha, SwatiShree Padhi, Madhabananda Kar, Shomereeta Roy, Prasanta Maiti, Birendranath Banerjee Oncomedicine 2017; 2: 71 - 79.
Cells towards the edge of the colony are in intimate contact with the feeder cell layer, which produces
stem cell maintenance factors such as the BMP antagonist gremlin [21], GDF - 11, and GDF - 8 [34].
His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions,
including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.
Once internalized, these dipeptide species act as nutrients for the CML stem cells and play a role in
CML stem cell maintenance.
Extraembryonic endoderm cells might secrete BMP and Wnt antagonists that enable neighboring cells in the center of the colony, well away
from stem cell maintenance signals, to undergo anteriorization and neural commitment.
These factors, along with stem cell autocrine factors such as nodal and GDF - 3, might maintain a high local ratio of SMAD2 / 3 to SMAD1 signaling to
drive stem cell maintenance.
Andrea worked with Jan Lohmann
on stem cell maintenance in the plant Arabidopsis before moving to the field of trafficking.
Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in
cancer stem cell maintenance and survival, described in previously published work by the Institute.
Under these culture conditions, which provide
for stem cell maintenance and inhibition of differentiation, as stem cell marker expression begins to drop, cells switch on the expression of lineage specific transcription factors at the RNA level.
Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types,
including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.
Singh, R. P., Franke K., Kalucka J., Mamlouk S., Muschter A., Gembarska A., Grinenko T., Willam C., Naumann R., Anastassiadis K., Stewart A. F., Bornstein S., Chavakis T., Breier G., Waskow C., and Wielockx B. HIF - prolyl hydroxylase 2 (PHD2) is a critical regulator of
hematopoietic stem cell maintenance during steady - state and stress.
The team is also applying the approaches outlined in this paper to cells in the intestine and skin to study basic ideas
of stem cell maintenance and differentiation to relate back to similar mechanisms in the heart.
Numb is also a known regulator of Notch, a protein implicated
in stem cell maintenance, and together, these observations have driven the development of new stem cell research projects, ranging from transcriptional profiling analysis of normal and cancer stem cells, to the in - depth characterisation of a number of critical signalling / endocytic pathways involving Numb / Notch / p53 (2, 3).
«In our study, we set out to establish which tissue signals are important to
stem cell maintenance and functionality, and which HSC signals influence the microenvironment,» explains Prof. Robert Oostendorp from TUM's university hospital, Klinikum rechts der Isar, where he works at the III.
Dr. Aguiar indicated that α - KG has been recently identified as a critical regulator of aging and
stem cell maintenance.
There is an entire family of Wnt proteins that play an important role in embryonic development,
stem cell maintenance, tissue regeneration, bone growth, stem cell differentiation and many human cancers.
A stem cells» immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for
stem cell maintenance.
The Wnt pathway plays a critical role in
stem cell maintenance, tissue regeneration and other important developmental processes.
We studied the expression of a panel of five pluripotency genes, including the transcription factors Oct - 4 and nanog, DNMT3b (a DNA methyltransferase required for de novo DNA methylation during development), GDF3 (a TGF beta superfamily member expressed specifically by ES cells) and TDGF - 1 (Cripto, a co-receptor for
the stem cell maintenance factor nodal), and two to three genes each characteristic of early stage ectoderm, mesoderm, and endoderm lineage commitment.
However piwi, while expressed in both somatic and germline cells, is required in the terminal filament for
stem cell maintenance but is also needed for cell division in the germline.