Sentences with phrase «surface proteins»
"Surface proteins" refer to proteins located on the outer membrane or surface of cells. They play important roles in interacting with other cells or molecules, controlling cell functions, and are responsible for various biological processes in the body. Full definition
The data referred to cell surface proteins that supposedly defined the cells.
scientificamerican.com
That makes them of similar size as many viruses, enabling the particles to enter cells by exploiting the same surface proteins that viruses use for this purpose.
Every now and then, however, a flu virus appears with surface proteins so different that our immunity to past infections does not help us.
Already, researchers have packaged cancer - fighting drugs into nanoparticles coated with part of a rabies surface protein that lets the virus slip into the central nervous system.
First, the parasite is incredibly complex, with multiple lifecycle stages and the ability to change its dominant surface proteins rapidly.
Viral tropism changes are thought to be due to changes in the structure of surface proteins of the virus that alter its ability to lock onto or dock with animal cells.
Analysis of surface proteins on the MDSCs identified S100A9 and S100A8 as the likely binding targets for the two peptibodies.
They identified these cells by looking for cell surface proteins called CD31 and CD146.
The protein is important because it is similar in structure to cell surface proteins in several pathogenic fungi.
The team looked at an outer surface protein of B. burgdorferi found in ticks — which can give clues about the vertebrate host — as well as the probabilities that different host species transmit the microbe during a tick bite, the number of larvae feeding on the animals, and population densities.
How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).
The Major Histocompatibility Complex (MHC) is a region of the genome that contains genes that code for a group of cell surface proteins known as Dog leukocyte antigens (DLA).
So the researchers illuminated virus surface proteins with X-rays to reveal their structure, a technique known as X-ray crystallography.
About Vanguard crLyme Vanguard crLyme is a next - generation multivalent vaccine which contains outer surface protein A (OspA) protein and a single OspC protein that is composed of antigenic material from seven common types of OspC found in Lyme - infected dogs in the U.S. 1 Its uniquely targeted design helps provide a broad spectrum of coverage while delivering a low - reactive vaccine by minimizing the amount of extraneous proteins administered to the dog.
In the viral surface protein hemagglutinin, a small set of mutations arises independently in multiple patients.
Influenza vaccines that better target the influenza surface protein called neuraminidase (NA) could offer broad protection...
Negotiations with the U.S. company that holds the license for commercialization of the vaccine — which contains a gene for the Ebola surface protein stitched into a livestock pathogen known as vesicular stomatitis virus (VSV)-- have needlessly delayed the start of the trial, Becker and several other scientists tell Science.
Magnetic beads the size of a bacterium attach to specific surface proteins on white blood cells, and a magnetic field nudges these cells out of the stream of CTCs.
It is estimated that there are 3 - 4 times more intracellular targets than surface protein targets.
A UNSW - led team of researchers analyzed strains of Bordetella pertussis from across Australia and found that many strains no longer produce a key surface protein called pertactin.
Mice immunized with this vaccine had high antibody titers against the HIV surface protein as well as heroin and its derivatives.
CANCER»S SWEET CLOAK Large surface proteins with chains of sugars (illustrated, yellow) on the outside of a cancer cell hide the tumor from immune attack and lull the immune system into a do - nothing trance.
Haemagglutinin, the main surface protein on flu viruses, binds to sugars on cells in the nose and lungs; the virus then enters the cells and replicates.
The introduced gene sequences, though, had modifications so that the erythroblasts produced surface proteins with an extra marker that's recognized by a protein called sortase.
The company's vaccine approach in both cases is to use viruslike particles (VLPs) containing surface proteins that make the VLPs resemble a virus, thereby eliciting the proper immune response — even though the VLPs lack the genes needed to replicate themselves.
Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.
The research team used single - gene amplification to study the gene responsible for HIV's major surface protein, env.
The new H and N surface proteins mean most people do not have antibodies to the virus, allowing it to go pandemic.
It seemed to be «violating the dogma» established with HIV and flu that the viral surface protein needs to be cleaved for the virus to enter the cell.
Haiyan Zhao, a postdoctoral researcher in Daved Fremont's laboratory at Washington University, purifies the Zika surface protein that allows the virus to enter and infect cells of the body.
Researchers of the Paul - Ehrlich - Institut have experimentally recombined segments of the virus surface protein E2, thus creating artificial proteins.
In summary, this study has identified a novel part of the parasite surface protein that is a key target of inhibitory antibodies and represents a candidate for a second generation malaria subunit vaccine.
GSK has committed to manufacturing up to 10,000 doses of the vaccine, which consists of an Ebola surface protein stitched into a weakened chimpanzee adenovirus, by the end of the year.
The perilipins are lipid droplet surface proteins that contribute to fat metabolism by controlling the access of lipids to lipolytic enzymes.
They study how specific cell surface proteins regulate nervous system development, including formation of myelin, the insulating layer around neurons that degenerates in MS. Myelin ensures rapid flow of electrical signals, similar to the plastic coating around a wire and protects neurons from degenerating.
These work by blocking the virus's surface protein neuraminidase, which allows budding virus particles to break away from infected cells.
New research conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that higher levels of antibody against a different flu surface protein — neuraminidase (NA)-- were the better predictor of protection against flu infection and its unpleasant side effects.
«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.
A cocktail of three bNAbs that glom onto HIV's surface protein at different locations fared only slightly better.
Changes in Bacterial Growth Rate Govern Expression of the Borrelia burgdorferi OspC and Erp Infection - Associated Surface Proteins
Specifically, he noticed that a section of that protein, called M2e, remains stable even as the other viral surface proteins mutate.
Hannes Stockinger, the senior author of the study, adds: «If we coupled this delivery method with screening of patient's tumours for the presence of a unique surface protein, which we can target with the Fab fragment - functionalized liposomes, we might be able to treat tumours more efficiently and decrease the side effects of the delivered anti-cancer drugs substantially.
Extreme shifts in surface proteins explain why existing vaccines offer no protection against the new avian flu.
Work has begun on new strategies, including antibody - based therapies, that target the same AML surface protein, said the study's senior author Jeffrey Rubnitz, M.D., Ph.D., a member of the St. Jude Department of Oncology.
Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.
CRH, in turn, triggered production of the cell surface protein FasL; trophoblasts expressing FasL then form a protective shield of sorts around the embryo by forcing any attacking immune cells to self - destruct.