Sentences with phrase «surface receptors»

This communication involves the release of chemicals from neurons that stimulate cell surface receptors on other neurons.

The mistaken activation of certain cell - surface receptors contributes to a variety of human cancers.

Another lab ran into a similar problem when it tried to replicate work by Stanford stem cell biologist Irving Weissman and his colleagues, who reported in 2012 in the Proceedings of the National Academy of Sciences that an antibody to a tumor cell surface receptor called CD47 can slow tumor growth in mice.

«Cell surface receptors for signal transduction and ligand transport - a design principles study.»

Cardiomyocytes are especially difficult to purify because they do not express unique surface receptors.

For HIV to enter T cells, the virus first binds to a primary surface receptor CD4 and then to a coreceptor, either CCR5 or CXCR4.

The researchers have found that axons receive the message to die as a chemical signal via a cell surface receptor known as «death receptor 6.»

Recognition of IL - 23 by its cell surface receptor on cells primarily activates JAK2 and the downstream transcription factor STAT3 [44].

Investigators linked the ability of regulatory T cells to dampen the Th2 response in part to the ability of LKB1 to restrain expression of the cell surface receptor PD - 1 and possibly other receptors.

«Cell - surface receptor offers promising breakthrough for pancreatic cancer patients.»

In the findings, published in the Journal of Clinical Investigation on December 11, researchers reveal that co-expression of cell surface receptor integrin αvβ3 and transcription factor Slug — a master regulator of a cell's ability to self - renew and differentiate — identifies rare stem - like cells in patient - derived tumor samples that are associated with metastasis.

His latest technology, the microRNA (miRNA) switch, is designed to detect and sort live cells not by surface receptors, but by miRNAs.

The primate iron transport protein and a bacterial transferrin surface receptor are in an evolutionary battle for iron.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

A familiar class of cell - surface receptors turns out to offer an array of fresh targets that could yield new treatments for disorders ranging from HIV infection to obesity

From this stage in the bone marrow, the diverse array of antibodies and cell - surface receptors found on immune B cells and T cells, respectively, are made to counteract all the foreign invaders the human body encounters.

The cell - surface receptors naturally act like brakes to tell the immune system to not react as strongly during normal situations and help the immune system avoid damaging healthy tissue or causing autoimmunity.

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

The cell surface receptor HAESA (blue) is bound to the hormone IDA (magenta) and the helper protein SERK1 (orange).

Unlike other cancers, TNBC cells lack three surface receptors normally targeted in treatment, one of them an oestrogen receptor.

In a multi-step process, HIV enters the target cells by binding to the host surface receptor CD4 and a co-receptor, either CCR5 or CXCR4 [13].

We have compiled a large panel of proteins representing the cell surface receptor repertoire and secreted proteins from the blood stage of the malaria parasite.

Current treatments focus on modulating cell surface receptor response, especially dopamine receptors.

These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.

The Baird / Holowka laboratory employs a broad range of biochemical, biophysical, and imaging methods to investigate the structure and molecular mechanisms of cell surface receptors in the immune response.

Ahn published a Journal of Biological Chemistry paper on drugs that block viral entry by inhibiting the envelope protein's interaction with surface receptors.

Through binding cell surface receptors [IFN receptor (IFNR)-RSB-, IFNα activates classic JAK - STAT pathway, which in turn leads to the formation of ISGF3 complex.

At the cellular level, it signals through a cell surface receptor kinase - mediated signal transduction pathway instead of through the nuclear receptor family of transcription factors.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Not only did the cells churn out CRH, they also harbored cell surface receptors for the hormone.

When ingested, these antibodies attach themselves to a cell surface receptor called FcRN, which allows them to slip through into the bloodstream through the otherwise impenetrable cellular barrier.

In my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and rituals.

A cell surface receptor called a Vasopressin Receptor [1] and its length seems to be solely responsible for whether or not men are naturally prone to monogamy or not.

A given rise of [Ca2 +] i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2 +] i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors.

The paper, by V. Hegenauer at University of Tübingen in Tübingen, Germany, and colleagues was titled, «Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.»

Using this strategy, researchers can engineer specific cells to produce a surface receptor that binds to a chemical compound known as CNO, a derivative of clozapine.

This affords safe passage to a theoretically unlimited selection of carriers targeting distinct cell surface receptors.»

These are proteins whose amino acid sequences show the structural hallmarks of cell surface receptors but whose triggering molecules are as yet undiscovered.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

The toxins overcome the cell membrane by binding to a surface receptor, which conveys them into the cell's interior.

By binding to the surface receptor, the toxins are able to overcome the cell membrane.

Normally, antibodies that react to surface receptors unique to the desired cell are used for this purpose.

They injected a mutant gene for a cell - surface receptor for bmp into the right legs of two - day - old chicken embryos.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

The networks provide structural integrity to tissues and serve as ligands for integrin cell - surface receptors.