Sentences with phrase «synaptic loss»

But the new findings «are the first clear evidence for a molecular and cellular mechanism of synaptic loss in schizophrenia,» said Jonathan Sebat, chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases at the University of California, San Diego, who was not involved in the study.

The scientists also attempted to correlate all these minor synaptic losses with the subjects» level of dementia.

More recently, his lab started studying the genetic basis of human brain evolution as well as the signaling pathways underlying synaptic loss during early stages of Alzheimer's Disease progression.

II - What are the signaling mechanisms underlying synaptic loss during early stages of Alzheimer's Disease?

It also revealed synaptic loss in three patients with epilepsy compared to healthy individuals.

Temporal changes in synaptic proteins in hippocampal slices indicated acute synaptic loss, followed by synapse formation and maintenance phases.

Interestingly, they did not observe such changes in the CA1 layer, suggesting that synaptic loss in the aging brain is region - specific.

To test whether the Müller glia were truly the key players in the synaptic loss, the team used a gene - editing technique to remove a specific gene from Müller glia cells.

«Much to our surprise, in studying the fate of eight neuronal and synaptic markers in our subjects» prefrontal cortices, we only observed very minor neuronal and synaptic losses.

Our study therefore suggests that, contrary to what was believed, neuronal and synaptic loss is relatively limited in Alzheimer's disease.

Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

Abstract: Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

mThy1 - AS mice administered only control IgG1 suffered dendritic atrophy (as suggested by reduced staining with MAP2) and synaptic loss (evaluated with postsynaptic density - 95 (PSD - 95) and synaptophysin) across several regions of the brain, but this neurodegenerative damage was substantially prevented in mice administered 1H7, 5C1, or 9E4.

Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism - like phenotype.

Her research interest is in neurodegenerative disease, specifically in the synaptic loss associated with Alzheimer's disease, and mechanisms of learning, memory, and consciousness.