Sentences with phrase «target of rapamycin»

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.

Whitehead Institute researchers have elucidated how the growth - regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine.

In cancer, PAT function has been related to the amino acid - sensing engine that drives activation of the mammalian target of rapamycin complex 1 (mTORC1), which is an important target for existing and new anti-cancer drugs.»

Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase — Positive Anaplastic Large Cell Lymphoma

Interactome mapping of the phosphatidylinositol 3 - kinase - mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor - 1 as a new glycogen synthase kinase - 3 interactor

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor (s) to regulate insulin - like peptide (ILP) synthesis and / or secretion in the insulin - producing cells.

Huynh, T.N., Santini, E., and Klann, E. (2014) Requirment of mammaliant target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in -LCB- alpha -RCB- 4 - and Protein Phosphatase 2A - dependent Fashion

Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide - Induced Lung Injury and Apoptosis

Recent studies highlighted a critical role for glutamine, which had been traditionally considered as a nutritionally non-essential amino acid, in activating the mammalian target of rapamycin cell signaling in enterocytes.

Natural plant - derived compounds found in onions, along with broccoli, green tea and strawberries, can suppress the «engine - of - aging» enzyme Target of Rapamycin (TOR), the enzyme that regulates cellular growth and proliferation in the human body.

Whitehead Institute scientists have at last answered the long - standing question of how the growth - regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine — itself a key player in modulating muscle growth, appetite, and insulin secretion.

Huber, K.M., Klann, E., Costa - Mattioli, M., and Zukin, R.S. (2015) Dysregulation of mammalian target of rapamycin signaling in mouse models of autism.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

The Leucine content of complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats.

To block the FA repair pathway in leukemic cells, researchers tested the inhibition of a protein called mTOR (mammalian target of rapamycin).

Called mTOR in mammals, for the term «mammalian target of rapamycin,» this pathway has a critical evolutionary value — it helps an organism avoid too much cellular expansion and growth when energy supplies are insufficient.

They indicate that mammalian target of rapamycin (Mtor)- dependent inhibition is a viable therapeutic option to prevent the development of blast trauma - induced HO.

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

It is well known that seizures produce learning, memory and behavioral deficits, and that they trigger abnormally high activity of two signaling pathways in the brain: the phosphoinositide 3 - kinase (PI3K) and mechanistic target of rapamycin (mTOR) cascades.

SQLE increased the NADP + / NADPH (reduced form of NADP +) ratio, which triggered a cascade of events involving oxidative stress — induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A - mediated epigenetic silencing of PTEN, and activation of AKT - mTOR (mammalian target of rapamycin).

In addition, several autism - associated genes regulate synapse number, often via a signaling protein known as mTOR (mammalian target of rapamycin).

The authors also found that viral persistence in CSF correlated with the activation of the mechanistic target of rapamycin (mTOR) pathway, which has been shown to be related to the development of brain tissue and brain malformations.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

Rapamycin gave mTOR its name — mechanistic target of rapamycin.

Scientists from the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Center (CNIO), led by Nabil Djouder, have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mammalian / mechanistic Target of Rapamycin); a protein that is altered in human diseases such as cancer and diabetes, processes associated with aging, as well as in certain cardiovascular and neurodegenerative pathologies.

The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin).

About 25 years ago, Prof. Michael Hall discovered the protein «Target of Rapamycin» (TOR) at the Biozentrum.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

For a long time it has been known that the protein TOR — Target of Rapamycin — controls cell growth and is involved in the development of diseases such as cancer and diabetes.

The chemical rapamycin is used clinically as an immunosuppressant and as an anti-cancer agent that works by inactivating a protein named TOR (Target Of Rapamycin).

The first step was to identify its target: an intracellular protein named TOR (Target Of Rapamycin), which stimulates the growth of cells.

Furthermore, niclosamide showed significant antitumor activity against a panel of cervical cancer cell lines via inhibition of mitochondrial respiration and the mammalian target of rapamycin (mTOR) signaling pathway [42].

Buck President and CEO Brian Kennedy, PhD has performed ground - breaking research on aging in mice, specifically focusing on a nutrient - sensing pathway called mTOR (mechanistic Target of Rapamycin).

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

Three main pathways has been demonstrated so far to control lifespan in mammals involving: insulin / insulin like growth factor1 (IGF1), tuberous sclerosis complex (TSC) / mammalian target of rapamycin (mTOR), and sirtuins.

The protein complex GATOR1 (for «GAP activity toward Rags») inhibits the mTOR (for «mechanistic target of rapamycin complex 1») pathway.

mammalian target of rapamycin (mTOR); cyclin dependent kinase inhibitor - 2A

Her main research interests lie with investigating key signaling mechanisms in retinal pigment epithelium, with the focus on the pathway mediated by mechanistic target of rapamycin (mTOR), and to identify molecular targets that can potentially be translated into interventional targets for treating chronic ocular diseases such as AMD.

Mechanistic target of rapamycin (mTOR) is a key regulatory protein that controls the balance between cellular anabolism and catabolism.

In this study, we hypothesized that the mammalian target of rapamycin (mTOR) pathway, which functions downstream of AKT, mediates the oncogenic effects of activated PI3K / AKT in ALK + ALCL.

-- Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

One enzyme, RagA, has been found to regulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway in cells according to glucose and amino acid availability.

Kapahi came to the Buck in 2004 as a fruit fly researcher, having been the first to demonstrate that the TOR pathway (a growth signaling pathway named for the Target of Rapamycin) mediates the effects of dietary restriction, which has been shown to extend lifespan in several species.