«This brings these members of the epothilone class within range of suitability as payloads for antibody - drug conjugates, a new paradigm
for targeted cancer therapy.»
These data suggest that a careful and systematic evaluation
of targeted cancer therapies on cognitive functions in preclinical models may constitute a strategy of prevention by selection of treatments exhibiting minimum brain co-morbidities.
EMD Serono, Kirschbaum says, «focuses on the development of
targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»
Published in the Nature Communications journal, this research opens a new avenue to improve
targeted cancer therapy by harnessing the body's own immune system to control and eliminate cancer cells.
He envisions anti-CD47 drugs being used both as an adjunct to
existing targeted cancer therapies and as a stand - alone treatment: «When you've finished surgery or radiotherapy and there's very little tumor left, this antibody might work all by itself.»
The cancer gene dependent vulnerability to apoptosis has promise to be the prime target for
future targeted cancer therapies but first, we need to understand the cell pathways that are causing this vulnerability.
Since the
first targeted cancer therapy to treat chronic myelogenous leukemia became available in 2001, there has been an explosion in genomic technology.
Their surprising discovery demonstrates that the vitamin A derivative ATRA (all - trans retinoic acid), a treatment for APL that is considered to be the first example of
modern targeted cancer therapy, can block multiple cancer - driving pathways and, at the same time, eliminate cancer stem cells by degrading the Pin1 enzyme.
The researchers say these new findings predict that a large proportion of Pten tumors will be hypersensitive to Eg5 - inhibiting drugs, providing new opportunities
for targeted cancer therapy.
«
Targeted Cancer Therapy May Treat Resistant Gynecologic Cancers.»
Targeted cancer therapies have strengths and weaknesses.
However, many of
these targeted cancer therapies have been more frequently identified for adult patients.
DOYLESTOWN, Pa. (January 23, 2018)-- For decades, researchers have tried to
target cancer therapies to only the cancerous cells, to avoid the toxic bystander effects of standard chemo and radiation therapy to normal cells.
Finally, Dr. Lau mentioned some future directions for
targeted cancer therapy.
My work is in the emerging field called:
Targeted Cancer Therapy (TCT).