This general approach, known as lineage - tracing, has been a mainstay of classical developmental biology research and has greatly clarified knowledge
of tissue stem cells during the last decade.
A novel mechanism — similar to how
normal tissue stem cells respond to wounding — might explain why bladder cancer stem cells actively contribute to chemo - resistance after multiple cycles of chemotherapy drug treatment.
The researchers suggest that a single expandable embryonic lung progenitor population with broader developmental competence may eventually be used as an alternative for region - restricted
adult tissue stem cells in regenerative medicine.
«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal
tissue stem cells respond to wound - induced damages.»
«We found that, contrary to popular belief,
tissue stem cells derived from sick hearts do not contribute to heart healing after injury,» said Prof. Leor.
«We have developed a drug that acts like a vitamin
for tissue stem cells, stimulating their ability to repair tissues more quickly.
Whether this recovery of
tissue stem cell numbers is due to a replenishment of the stem cell pool from more differentiated cells, or due to an increase in «asymmetric» stem cell divisions that allow one stem cell to generate two new ones, remains to be answered, he said.
In normal cells, this is a part of the wound repair process when PGE2
induces tissues stem cells to regrow; in cancer PGE2 ironically induces regrowth of more cancer stem cells in between chemotherapy cycles, Kurtova and Xiao said.
I don't know too many other consortia which can integrate expertise in embryonic and
tissue stem cell biology, tissue regeneration and repair, bioengineering and nanotechnology, materials science, genomics and bio-informatics.
«Regenerative medicine relies on the ability to turn pluripotent human stem cells into
specialized tissue stem cells that can engraft and function in patients,» said Irving Weissman, MD, the director of Stanford's Institute for Stem Cell Biology and Regenerative Medicine, and also of its Ludwig Cancer Center.
«Instead, some cancer cells seem to reactivate and corrupt programs that govern
fetal tissue stem cell function, including programs from their neighboring cells that constitute the surrounding fetal stem cell landscape, or microenvironment.»
CBR is dedicated to advancing the clinical application of cord blood and
cord tissue stem cells by partnering with institutions to establish FDA - regulated clinical trials for conditions that have no cure today.
Answering this question will require knowledge of whether normal stem cells are susceptible to cancer - causing mutations; however, this has proved difficult to test because the identity of most
adult tissue stem cells is not known.
The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult
connective tissue stem cells to form into preliminary form of chondrocytes — the cells that make healthy tissue cartilage — and secrete extracellular matrix similar to natural cartilage.
This latter postulate, called «cancer stem cell (CSC) hypothesis» was recently revived (10) mainly due to progress made on studies of
normal tissue stem cells.
Today she is fascinated by the creature, and has shown that many of the mechanisms in axolotl regeneration — such as those involving muscle -
tissue stem cells — are not so different from those found in humans.