Sentences with phrase «to induce obesity»

Resistance to diet - induced obesity in mice with a single substituted chromosome.

When planning a diet - induced obesity study, the composition of the high - fat diet deserves attention.

Meal pattern analysis of diet - induced obesity in susceptible and resistant rats.

In the current study, we found that while a high fat diet containing Plenish also induced obesity, glucose intolerance and fatty liver, it did not induce insulin resistance as did the conventional soybean oil.

OpenSource Diet D12492 has set the standard for diet - induced obesity models in mice.

In male mice, however, diet - induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

Rich in unsaturated fats, especially linoleic acid, soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice.

To make their discovery, Jin and colleagues used both genetically obese mice and mice with diet - induced obesity as models.

In the early days of rodent diet - induced obesity research, some scientists used what is known as the cafeteria diet.

Many high - fat diets used in laboratory animal research contain more saturated fat such as lard, beef tallow, or coconut oil and these diets are quite capable of inducing obesity in susceptible strains.

To explore if Hedgehog signaling also has an effect on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in fat cells would activate when they ate a high - fat diet.

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet - induced obesity via Nrf2 mediated pathway.

They found that the GM soybean oil is just as unhealthy as regular soybean oil in that it also induces obesity, diabetes and fatty liver.

Adaptive changes in adipocyte gene expression differ in AKR / J and SWR / J mice during diet induced obesity.

Sex differences during the course of diet - induced obesity in mice: adipose tissue expandability and glycemic control

And most research on diet and health or PTSD comes from correlational studies, as no ethics committee will let you induce obesity or traumetize someone for an experiment.

to induce obesity in cattle!

Research on SLC13A5 has focused on its role in obesity and diabetes; knocking out the SLC13A5 gene in mice prevents high - fat diet - induced obesity.

«Together, our data strongly suggest that cutaneous gene therapy with inducible expression of GLP1 can be used for the treatment and prevention of diet - induced obesity and pathologies,» the authors wrote.

«Loss of inflammatory signaling molecule protects mice against diet - induced obesity.»

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Next, the researchers plan to identify critical upstream and downstream mechanisms of endocannabinoid signaling in western diet - induced obesity, as well as the possible specific dietary constituents in western diet (e.g., sucrose) that drive overeating as a result of elevated peripheral endocannbinoid levels.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

«The novelty of our study is the multifactorial approach, which made it possible to show that females are more sensitive to androgen exposure during fetal life while males are more sensitive to diet - induced obesity.

«How a Western diet leads to overeating and obesity: Peripheral endocannabinoid signaling identified as a pharmaceutical target for overeating associated with diet - induced obesity.»

To examine the role for endocannabinoids generated in peripheral organs in controlling the overeating of western diet, DiPatrizio and coauthor Donovan A. Argueta, a bioengineering Ph.D. student in his lab, used a mouse model of western diet - induced obesity (chronic exposure to high levels of sugars and fats).

After birth, half of the mice were exposed to high - fat - high - sucrose (HFHS) diet - induced obesity to also investigate the effect of diet in the offspring.

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

Professor Tiganis said this fundamental process normally serves to maintain body weight but in diet - induced obesity this mechanism goes awry.

«Modulation of Fgf21 gene in early - life ameliorates adulthood diet - induced obesity.»

These findings establish that βARs are necessary for diet - induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet - induced obesity.

In their study, researchers used animal models of diabetes and models of diet - induced obesity and insulin resistance to see how insulin resistance and too much sugar or fat affect glucose transporters in the kidney.

Dr. Eibl and colleagues set out to develop diet - induced obesity and development of pancreas cancer in a set of mice and then compare them to another set of mice that are genetically identical but not given a high - fat, high - calorie diet.

These results contribute to the understanding of the mechanisms that underlie diet - induced obesity and offer insight into how fermentable fibers might promote better health.»

In aged mice and rodents with diet - induced obesity, WBV reduced adiposity and lowered serum triglycerides (47 — 49), but the magnitude of these effects had never been examined relative to exercise.

Osteocalcin - deficient mice exhibit insulin resistance and hyperglycemia (27), and administration of undercarboxylated osteocalcin protects against the metabolic consequences of diet - induced obesity in WT mice (30, 60).

Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both the genetically obese mice and the mice with diet - induced obesity.

In the first part, they established the mouse model that mimics multiparity - induced obesity in humans.

«Beta - cell replication occurs naturally in diet - induced obesity and in pregnancy, so this process gives us a target for therapy,» Dr. Kulkarni notes.

Specific synbiotics in early life protect against diet - induced obesity in adult mice Mona Mischke — Diabetes, Obesity, and Metabolism

The increased rBAT was sufficient to maintain normal body temperature and also protect against diet - induced obesity: When the control and mutant mice were fed a high - fat diet, the mutant mice did not gain more weight than the control mice.

Pioglitazone prevents hypertension and reduces oxidative stress in diet - induced obesity.

During his postdoctoral training, he studied the development of diet - induced obesity in selectively - bred strains of Sprague - Dawley rats that either become obese or remain lean when exposed to a high - fat diet.

Following that Michael worked as a postdoctoral fellow at the Technical University in Munich, Germany on a neuroproteomics project aiming to identify novel protein candidates involved in the development of diet - induced obesity.