Sentences with phrase «transcriptional factors»
Transcriptional factors are proteins in our cells that control the activity of genes. They help to determine which genes are turned on or off, sending instructions to the cell about when and how to make certain proteins. Full definition
After receiving her Ph.D. in immunology from the Open University, United Kingdom, where she researched the identification of transcriptional factors regulating the unique phenotype of the human blood — brain barrier, she joined the Roche Brain Shuttle program as a postdoctoral fellow.
sciencemag.org
Dillin's team then screened 15 other genes from the forkhead family — transcriptional factors important to development and possibly longevity, to which the gene for daf - 16 belongs — to see if any of them were necessary to increase longevity after dietary restriction.
Using this strategy, Cas9 is able to deliver transcriptional factors to specific genes and regulate their expression.
In parallel, the mRNA expression of key transcriptional factors for Th1 cells (T - bet), Th17 cells (Rorc), and Tregs (Foxp3), as well as Ifng and Il17a, also were decreased in a dose - dependent manner (Supplemental Fig. 4D).
In this study, we develop a reproducible protocol for efficient reprogramming mouse neural progenitor cells (NPCs) on human foreskin fibroblast (HFF) cells via retroviral transfer of human transcriptional factors OCT4 / SOX2 / KLF4 / C - MYC.
Transcriptional factor FOXO3a controls the persistance of memory CD4 + T cells during HIV infection.
The nuclear factor erythroid2 - related factor (Nrf2) is a genetic transcriptional factor that functions as the key controller of the redox homeostatic gene regulatory network.
Evidence from animal studies has suggested that PFASs may be involved in altering energy metabolism and thyroid hormone homeostasis [15 — 17], likely through the activation of various transcriptional factors, such as the peroxisome proliferator - activated receptors (PPARs)[18 — 20].
«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.
Using lentiviral vectors to force the expression of three of these transcriptional factors, Dmrt1, Gata4, and Nr5a1, they were able to directly reprogram mouse skin cells into functional Leydig - like cells, which showed normal gene activity and were capable of producing testosterone.
A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.