Sentences with phrase «transforming growth factor»

As a result, they gained new understanding of how a substance known as transforming growth factor triggers cell transformations.

It also increased transforming growth factor 1, a protein which controls cell proliferation and both collagen type 1 and type 3.

Human transforming growth factor - beta complementary DNA sequence and expression in normal and transformed cells.

Studies by his team and others indicate that these fields can increase a joint's production of natural anti-inflammatory agents, such as transforming growth factor - beta.

Overproduction of transforming growth factor beta (TGF - B) is associated with increased chronic inflammation, autoimmune responses, and increased susception to pathogenic invasion.

Earlier laboratory studies had shown that fetal fibroblasts, closely related cells from the fetus, respond to tamoxifen by producing a natural peptide called transforming growth factor beta - 1 (TGF beta - 1).

Sp1 binds to the GC - rich sequence on the proximal region of p21waf1 / cip1 promoter and acts as a mediator for the induction of p21waf1 / cip1 gene caused by transforming growth factor β (TGF - β; ref.

In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor β1 and the potential for in situ chondrogenesis.

The X-vivo 10 medium contained X-VIVO 10 (Cambrex Bio Science) medium, 0.12 ng / ml transforming growth factor β1 (Sigma, St. Louis, MO) and the same supplements included in the conventional hESC medium.

When the cytokine transforming growth factor beta (TGF - beta) is sensed by the TGF - beta receptor, the receptor concentrates within the primary cilia of cells.

In clinical trials, it has been shown to induce transforming growth factor - beta, triggering the accumulation of extracellular matrix, which continues through the remodeling phase of wound repair.

Tolerogenic cytokines, like transforming growth factor - beta (TGF - β) and IL - 10, are involved in suppressing the inflammatory response and are the predominant breast milk cytokines.

Previous research had shown that AHR activation decreases transforming growth factor beta (TGFβ), a cytokine that induces myofibroblast formation.

In the course of their research, they found that the protein transforming growth factor B1 (TGF - B1), contained in megakaryocytes, signaled quiescence of hematopoietic stem cells.

The hedgehog system machinery controls transforming growth factor - ß - dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis.

Type B transforming growth factor is a growth stimulator and a growth inhibitor.

In addition to these applications, new uses may be developing; these involve the transfer of genes with the potential of increasing efficacy â $» for example, the transduction of mesenchymal stem cells with transforming growth factor Î ² 1 to allow chondrogenesis to occur in vitro before the cells are used clinically.

Power frequency fields promote cell differentiation coincident with an increase in transforming growth factor - b 1 expression.

Don't worry, you won't wake up as a freaky human / bee combination (although that might have advantages), but this unique fatty acid can stimulate transforming growth factor 1, another skin master regulator which controls collagen.

Studying a mouse model of Marfan, pediatric cardiologist Harry Dietz of Johns Hopkins University in Baltimore, Maryland, found that the animals shared a defect that hadn't been previously considered: an overactive protein called transforming growth factor - β (TGF - β).

Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6.

But in Murphy's worms, a mutation in a gene known as transforming growth factor beta (TGF - β) enabled the production of high - quality eggs right up to the day they died.

The antibodies also make matters worse by attaching to receptors on the macrophages, which in response spit out transforming growth factor β, an immune messenger that activates collagen - producing fibroblasts, leading to fibrosis of tissues.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

In their Molecular Cell study, the Salk Institute researchers report that a protein known as transforming growth factor beta (TGF - β), considered a tumor suppressor in early cancer development, can actually promote cancer once a cell drifts into a pre-cancerous state.

Variation in the biochemical forms of transforming growth factor - alpha present in human milk and secreted by human milk macrophages.

In contrast, Loeys - Dietz is traced to a genetic defect in the TGF — beta (transforming growth factor — beta) signaling pathway.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Mizushima's team says that HSP70 amplifies the expression of chemicals such as insulin - degrading enzyme and transforming growth factor beta 1, linked to the destruction of the beta - amyloid proteins (Journal of Neuroscience, DOI: 10.1523 / jneurosci.5478 - 10.2011).

Richman's team focused first on bone morphogenetic proteins (BMPs)-- a type of transforming growth factor that helps bones grow and may determine which parts of the face neural crest cells become.

Dr. Doyle then trained as a postdoctoral scholar at Stanford University under the mentorship of Dr. Marion Buckwalter, researching the role of transforming growth factor (TGF)- beta signaling after stroke and developing a model of poststroke dementia.

Researchers showed that a protein called transforming growth factor - β is key both in axolotl regeneration and in preventing scar tissue in injured human embryos during the first trimester.

Activins and myostatin belong to the transforming growth factor - β (TGF - β) family of proteins, which both researchers have been investigating for a number of years.

In an article published online April 5, 2018 by JCI Insight, the researchers showed that a specific form of transforming growth factor (TGF)- beta binds the membrane receptor glycoprotein - A repetitions predominant (GARP) to regulate B cell activity.

Mathematical models employed by the researchers suggest that the key is a molecule that inhibits branching, namely, a protein called transforming growth factor - β (TGF - β), which is produced by mammary cells and which is known to stop branching in developing tissues.

Myostatin (MSTN) is a transforming growth factor - ß (TGF - ß) family member that plays a critical role in regulating skeletal muscle mass [1].

Myostatin is a transforming growth factor - ß family member that normally acts to limit skeletal muscle growth.

These studies demonstrate that muscle mass in mice is controlled by multiple members of the transforming growth factor - ß superfamily acting in concert.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

Cell contact, prostaglandin E (2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 (High) forkhead box P3 + regulatory T cells.Clin Exp Immunol 2009; 156: 149 - 160.